Use of Curcumin to Decrease Nitric Oxide Production During the Induction of Antitumor Responses by IL-2

Song, Min Young; Yim, Joo Yun; Yim, Jun-Mo; Kang, In-Jeong; Rho, Hye-Won; Kim, Hee Sun; Yhim, Ho‐Young; Lee, Na-Ri; Song, Eun-Kee; Kwak, Jae-Yong; Sohn, Myung‐Hee; Yim, Chang-Yeol

doi:10.1097/cji.0b013e3182056ec4

Cited by 23 publications

(9 citation statements)

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“…In recent years, curcumin and its derivatives have demonstrated promising anti-inflammatory activities by inhibiting several important inflammatory mediators such as tumor necrosis factor (TNF)-α, IL-6, IL-1β, nitric oxide (NO) and nitric oxide synthase (iNOS) [ 26 , 27 ]. The therapeutic potentials of curcumin are attributed mainly to its chemical structure, in which the presence of various substituents such as methoxy, hydroxyl, alkyl, halogens, amino, nitro, nitril, acetamido, carboxyl, benzene, heterocyclic and condensed rings in their structure may influence their specific biological activities to a certain degree [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT)

Razali

Nazarudin

Lai

et al. 2018

BMC Complement Altern Med

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BackgroundHistamine is a well-known mediator involved in skin allergic responses through up-regulation of pro-inflammatory cytokines. Antihistamines remain the mainstay of allergy treatment, but they were found limited in efficacy and associated with several common side effects. Therefore, alternative therapeutic preferences are derived from natural products in an effort to provide safe yet reliable anti-inflammatory agents. Curcumin and their derivatives are among compounds of interest in natural product research due to numerous pharmacological benefits including anti-inflammatory activities. Here, we investigate the effects of chemically synthesized curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65), in reducing cytokine production in histamine-induced HaCaT cells.MethodsInterleukin (IL)-6 cytokine production in histamine-induced HaCaT cells were measured using enzyme-linked immunosorbent assay (ELISA) and cytotoxicity effects were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Real-time polymerase chain reaction (RT-qPCR) was carried out to determine the inhibitory effects of MS65 on nuclear factor-kappa B (NF-κB) and mitogen activated protein kinase (MAPK) pathways.ResultsHistamine enhanced IL-6 production in HaCaT cells, with the highest production of IL-6 at 97.41 ± 2.33 pg/mL after 24 h of exposure. MS65 demonstrated a promising anti-inflammatory activity by inhibiting IL-6 production with half maximal inhibitory concentration (IC50) value of 4.91 ± 2.50 μM and median lethal concentration (LC50) value of 28.82 ± 7.56 μM. In gene expression level, we found that MS65 inhibits NF-κB and MAPK pathways through suppression of IKK/IκB/NFκB and c-Raf/MEK/ERK inflammatory cascades.ConclusionTaken together, our results suggest that MS65 could be used as a lead compound on developing new medicinal agent for the treatment of allergic skin diseases.

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Section: Discussionmentioning

confidence: 99%

Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT)

Razali

Nazarudin

Lai

et al. 2018

BMC Complement Altern Med

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“…Besides COX-2, inducible nitric oxide synthase (iNOS) is also known to be implicated in inflammatory responses (63). Indeed, iNOS is reported to be another target for curcumin (64). iNOS results in NO generation, a wellknown pro-inflammatory mediator (65).…”

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin

Boroumand¹,

Samarghandian²,

Hashemy³

2018

J Herbmed Pharmacol

119

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“…Many studies have reported inhibition of proliferation and induction of apoptosis in response to various anti-cancer reagents like NO-aspirin [42,43], quercetin [44][45][46], curcumin [47][48][49], and resveratrol [50,51]. Here, we report that compounds 1-3 induced colon cancer cell death via an anti-proliferative/proapoptotic mechanism.…”

Section: Uptake Of Compounds 1-3 Was Detected Via Flow Cytometrymentioning

confidence: 59%

An in vitro study on the effect of synthesized tin(IV) complexes on glioblastoma, colorectal, and skin cancer cell lines

Williams¹,

Lewis-Alleyne²,

Solomon³

et al. 2016

Biomed Res Clin Prac

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Abstract((E)-2-(2-hydroxybenzylideneamino)phenolato-2,2-diphenyl-6-aza-1,3-dioxa-2-stanna- [d,h] dibenzocyclononene, [Sn(Ph 2 SB)] (compound 1, where Ph 2 SB=(E)-2-(2-hydroxybenzylideneamino)phenolato Schiff base) and two novel compounds, [[SnPh 2 (F-azoSB)] (compound 2, where F-azoSB=4-((E)-(4-fluorophenyl) diazenyl)-2-((E)-(2-hydroxyphenylimino)methyl)phenolato Schiff base), [[SnPh 2 (sulf-azoSB)]0.125CHCl 3 (compound 3, where sulfamerazineazosalSB=4-((E)-(4-hydroxy-3-((E)-(2-hydroxyphenylimino)methyl)phenyl)diazenyl)-N-(4-methylpyrimidin-2-yl) benzenesulfonamide Schiff base), and the control compound, cisplatin (compound 4) were analysed to comparatively determine their effect on cancer cell growth. Anti-cancer properties of compounds 1-4 were examined using glioblastoma (U-1242 MG), colorectal (HT-29 and HCT-116), and skin (A431) human cancer cell lines. With regards to human glioblastoma cells, compounds 1 and 3 demonstrated anti-proliferative capacity in the cell line tested. Specifically, compounds 1 and 3 inhibited cell proliferation by 50% at concentrations between 10 and 50 µM. With respect to colon cancer cell lines, the IC 50 values for compounds 1-3 ranged from 3.04 ± 0.98 to 104.51 ± 13.87 µM. In the case of HCT-116, this translates to a 3-to 73-fold inhibitory effect of compounds 1-3 over cisplatin. In all cell lines tested, the chemo-effect was more pronounced with compounds 1-3 than with the control (compound 4); demonstrating that these azo-containing Sn(IV) complexes were more potent than compound 4. The overall effect of compounds 1-3 in the induction of appotosis and the inhibition of proliferation have defined an essential role for these compounds in chemotherapy. IntroductionFrom the late 1960s until the present, there have been significant advances in both the early detection and the treatments of cancer. Despite these advances overall incidences of cancer and deaths from cancer have increased during the same period [1]. These counterintuitive increases have been the impetus for development of new drugs for cancer treatment. In this context the organometallic compounds have been widely investigated as potential anti-tumour agents. Metallocene dihalide complexes Cp 2 MX 2 (where M=titanium, vanadium, niobium, or molybdenum) were the first early transition metal complexes that were shown to have anti-tumour activity. In addition, the organometallic-DNA and organometallic-nucleic acid interactions of these compounds have also been investigated [2][3][4]. More recently, ferricenium salts, organotin, and bismuth complexes have also emerged as examples of organometallic compounds that have been found to exhibit interesting anti-tumour activity [5].The biological activity of organotin compounds has become well known due to their practical applications as fungicides, bactericides, biocides, and pesticides [3,[6][7][8]. It is now well established that organotin compounds are very important in cancer chemotherapy [9] and as potential anti-cancer agents [10][11][12][13]. This is due in part to thei...

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Use of Curcumin to Decrease Nitric Oxide Production During the Induction of Antitumor Responses by IL-2

Cited by 23 publications

References 0 publications

Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT)

Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT)

Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin

An in vitro study on the effect of synthesized tin(IV) complexes on glioblastoma, colorectal, and skin cancer cell lines

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