Use of cytosolic and myofibril markers in the detection of ongoing myocardial damage in patients with chronic heart failure

Setsuta, Koichi; Seino, Yoshihiko; Ogawa, Takeshi; Arao, Masato; Miyatake, Yoshiko; Takano, Teruo

doi:10.1016/s0002-9343(02)01394-3

Cited by 118 publications

(85 citation statements)

References 19 publications

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“…3,5,38) However, most studies of the prognostic value of cTnT in acute coronary syndrome, chronic heart failure and pulmonary embolism have found that the cTnT level at a single point is an independent predictor of future cardiac events. 2,4,[6][7][8]20,39) The rate of cTnT detected by the assay in the present study is very low in healthy adults. 17) Thus, we believe that elevated cTnT even at a single point has clinical significance.…”

Section: Therapeutic Implications Of Ongoing Myocardial Damage In Hy-contrasting

confidence: 47%

“…cTnT is a sensitive marker for the detection of myocardial damage in patients with not only acute coronary syndrome but also with chronic heart failure [2][3][4][5][6][7][8] and pulmonary embolism. 20) Therefore, some hypertensive patients might have ongoing myocardial damage.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies including ours have shown that ongoing myocardial damage detected as elevated cTnT levels can discriminate patients with chronic heart failure (CHF) at increased risk for future cardiac events. [2][3][4][5][6][7][8] HT is an important precursor of heart failure. Several experimental studies have shown that myocardial damage or apoptotic cardiomyocytes are associated with HT.…”

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confidence: 99%

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Elevated Cardiac Troponin T Predicts Adverse Outcomes in Hypertensive Patients

et al. 2011

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SummaryOngoing myocardial damage detected as elevated serum cardiac troponin T (cTnT) indicates increased risk for future cardiac events in patients with chronic heart failure. Whether elevated cTnT is associated with adverse outcomes in patients with hypertension (HT) without left ventricular (LV) systolic dysfunction is unknown.We measured cTnT levels in 176 patients with essential HT without LV systolic dysfunction (LV ejection fraction ≤ 55%), renal failure, and prior cardiovascular or cerebrovascular diseases and 39 normal controls. Levels of cTnT were elevated ( ≥ 0.02 ng/mL) in 15 (9%) of the 176 patients and in 0 (0%) of the 39 normal controls (P = 0.04). The rate of diabetes mellitus (DM), the cardiothoracic ratio, plasma B-type natriuretic peptide (BNP) value, and LV mass index were significantly higher in patients with than without elevated cTnT (DM, 8/15 versus 29/161, P = 0.004; cardiothoracic ratio, 54.5 ± 4.5 versus 51.6 ± 5.2%, P = 0.04; BNP, 103.3 ± 142.3 versus 36.9 ± 50.7 pg/mL, P = 0.04; LV mass index, 227 ± 87 versus 152 ± 57 g/m 2 , P = 0.0001). Kaplan-Meier analysis demonstrated that significantly fewer (P < 0.000001) patients with, than without elevated cTnT remained free of events (hospitalization due to cardiovascular or cerebrovascular disease, n = 34). Stepwise Cox multivariate analysis revealed that elevated cTnT (hazard ratio, 6.58; P = 0.000001) and smoking (hazard ratio, 2.24; P = 0.04) were independent predictors of events.The present findings indicate that cTnT is a novel and useful predictor of future cardiovascular or cerebrovascular events in hypertensive patients. (Int Heart J 2011; 52: 164-169)

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Section: Therapeutic Implications Of Ongoing Myocardial Damage In Hy-contrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Elevated Cardiac Troponin T Predicts Adverse Outcomes in Hypertensive Patients

et al. 2011

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“…H-FABP elevations were also frequently noted among patients with other cardiovascular diseases. High H-FABP levels were observed in a considerable proportion of patients with heart failure, consistent with several reports documenting H-FABP elevations in heart failure patients (12,13). These reports stated that H-FABP is useful for assessing the severity of the prognosis in patients with heart failure.…”

Section: Discussionsupporting

confidence: 90%

“…Its dynamic features of liberation into circulating blood resemble those of myoglobin but are characterized by high specificity to myocardium. Nevertheless, H-FABP is slightly inferior to troponin and CK-MB in diagnostic specificity for AMI and has been described to be increased in other cardiogenic disorders, renal dysfunction, and disorders associated with skeletal muscle damage (1,(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Relationship between Heart-Type Fatty Acid-Binding Protein Levels and the Risk of Death in Patients with Serious Condition on Arrival at the Emergency Department

et al. 2005

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Objective Although heart-type fatty acid-binding protein (H-FABP) is a cardiac marker useful for early diagnosis of acute myocardial infarction (AMI), few data are available on its prognostic value. The objective of this study is to clarify the prognostic value of H-FABP in patients with a serious condition. Methods and PatientsWe conducted a prospective study of 617 patients who presented to the emergency department with a serious condition. The H-FABP levels on arrival at the emergency department were divided into four groups using their quartiles. The endpoint was death from any causes in-hospital.Results H-FABP ranged from 1.2 to 2,300 ng/ml, with a median of 19.9 ng/ml, a 25%-value of 6.7 ng/ml and 75%-value of 54.0 ng/ml. The unadjusted rate of the mortality increased progressively with increasing H-FABP quartile point (11% for quartile-I, 22% for quartile-II, 36% for quartile-III, and 38% for quartile-IV; p<0.001). After adjustment for age, gender, systolic blood pressure and the presence or absence of cardiovascular disease, H-FABP was the independent factor to predict the mortality.Conclusion H-FABP has proven to be an independent factor for prognosis in patients with a serious condition on arrival at the emergency department. (Internal Medicine 44: 1039-1045, 2005)

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Cardiac Troponins in Patients with Congestive Heart Failure

Adams¹

2007

Markers in Cardiology

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Use of cytosolic and myofibril markers in the detection of ongoing myocardial damage in patients with chronic heart failure

Cited by 118 publications

References 19 publications

Elevated Cardiac Troponin T Predicts Adverse Outcomes in Hypertensive Patients

Elevated Cardiac Troponin T Predicts Adverse Outcomes in Hypertensive Patients

Relationship between Heart-Type Fatty Acid-Binding Protein Levels and the Risk of Death in Patients with Serious Condition on Arrival at the Emergency Department

Cardiac Troponins in Patients with Congestive Heart Failure

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