Use of dienogest over 53 weeks for the treatment of endometriosis

Abstract

Long term DNG treatment beyond one year for endometriosis proved to be effective and safe. Ovarian chocolate cysts were markedly reduced by short-term use of DNG, while a longer duration was required to reduce the size of adenomyosis. The decision regarding the choice of therapy lies with the individual clinician, considering a balance of efficacy with expense and adverse effects.

Efficacy and safety of dienogest in patients with endometriosis: A single-center observational study over 12 months

“…Our data are in agreement with previous reports [812] in that dienogest was effective in reducing endometriosis-associated pain. Specifically, it is noteworthy that the size of recurrent endometriomas was significantly reduced by dienogest treatment, as in a previous Japanese study [12].…”

“…Our data are in agreement with previous reports [812] in that dienogest was effective in reducing endometriosis-associated pain. Specifically, it is noteworthy that the size of recurrent endometriomas was significantly reduced by dienogest treatment, as in a previous Japanese study [12]. Although the mechanism is not clear, dienogest treatment might suppress extracellular signal-regulated kinase 1/2 pathways, inhibit mammalian target of rapamycin, induce autophagy, and promote the apoptosis of endometriotic cells [13].…”

“…An extension study showed that the prolonged use of dienogest for another 53 weeks in those who completed 12 previous weeks of medication was also effective and safe during the follow-up period, and that the reduction of pain persisted even after cessation [8]. Another recent Japanese retrospective study also reported that longterm dienogest treatment beyond 1 year was effective and safe, and also showed that the size of ovarian chocolate cysts was significantly decreased by the short-term use of dienogest [12]. …”

Combination of microwave endometrial ablation and postoperative dienogest administration is effective for treating symptomatic adenomyosis

“…Additionally, dienogest was seen to prevent endometriosis‐related pain relapse and the recurrence of endometriosis lesions after surgery . In fact, dienogest has been deemed safe to use in the long term to relieve dysmenorrhea without adverse effects due to hypoestrogenism, such as decreased bone mass and hot flushes . However, we have seen that several patients with uterine adenomyosis‐related dysmenorrhea were resistant to treatment with dienogest.…”

Combined treatment of endometriosis in infertile patients with gonadotropin-releasing hormone agonist or dienogest

“…K. Sugimoto [17] доказа-на эффективность и безопасность применения пре-парата у больных с эндометриозом более 53 нед.…”