Use of Drug Release Testing to Evaluate the Retention of Abuse-Deterrent Properties of Polyethylene Oxide Matrix Tablets

Meruva, Saikishore; Rezaei, Leyla; Thool, Prajwal; Donovan, Maureen D.

doi:10.1208/s12249-020-01804-y

Cited by 9 publications

(2 citation statements)

References 37 publications

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“…The observed variability can be attributed to the inclusion or exclusion of micronized irbesartan particles from the 1.2 mm diameter micro-tablet during the compression operation. As suggested in the literature, there can be microscopic inhomogeneities within a macroscopically uniform blend 6,[34][35][36] (blend uniformity of all the blends in the current study ranged from 98-102%, n = 3) resulting in the formation of API-rich zone and API-deficient zone (as shown in Fig. 7a and 7c) which will consequently lead to the production of sub-potent and super-potent micro-/mini-tablets.…”

Section: Content Uniformity Of Individual Micro-tabletsmentioning

confidence: 56%

A Novel Use of Nanocrystalline Suspensions to Develop Sub-Microgram Dose Micro-Tablets

Meruva

Thool

Gong

et al. 2021

Journal of Pharmaceutical Sciences

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Section: Content Uniformity Of Individual Micro-tabletsmentioning

confidence: 56%

A Novel Use of Nanocrystalline Suspensions to Develop Sub-Microgram Dose Micro-Tablets

Meruva

Thool

Gong

et al. 2021

Journal of Pharmaceutical Sciences

Self Cite

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“…Hourly for 12 hr, a sample (5 mL) of the aliquot was removed, filtered and substituted with media. 22 Shimadzu UV-1700 was availed to measure the absorbance of these solutions at 278 nm.…”

Section: In Vitro Drmentioning

confidence: 99%

Central Composite Design Assisted Formulation Development and Optimization of Gastroretentive Floating Tablets of Dextromethorphan Hydrobromide

Chinthaginjala,

Ahad,

Kethandapatti Srinivasa

et al. 2023

Ind. J. Pharm. Edu. Res

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Objectives:The existing study is concerned with the formulation and optimization of dextromethorphan hydrobromide floating tablets via central composite design. Materials and Methods: Direct compression method was employed to prepare the tablets. Drug -excipient studies were executed through FT-IR and DSC analysis. The independent variables selected were the concentrations of Carbopol 934 (X 1 ) and HPMC K15M (X 2 ). The dependent variables designated were Floating Lag Time (FLT) and Drug Release (DR) at 12 hr. The model was found to be nonlinear and the curvature effect was significant. Hence, the system suggested to central composite design. Results: FT-IR studies demonstrated that there is no considerable interaction amid the drug and the excipients. DSC studies revealed that drug and excipient were compatible as there is no significant alteration in melting point of drug when blended with excipients. The precompression parameters of the formulations showed good flow properties. The evaluation of post compression parameters indicated that all the prepared formulations were within the specified limits. Floating lag time of formulations were marked to be less than 1 min and total floating time exceeding 12 hr. Percentage drug release of all formulations were in the range of 89.7% to 99.4%. The obtained design space/contour plots were used for selecting batches in desirable ranges. Conclusion: The results revealed that experimental design was successfully used to optimize polymer concentrations. It was determined that the central composite design would be used to formulate dextromethorphan gastroretentive floating tablets with fewer trials and higher quality features.

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Preferential Oxycodone Loss of Physically Manipulated Abuse Deterrent Oxycodone HCl Extended Release Tablets Prepared for Nasal Insufflation Studies

et al. 2021

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Use of Drug Release Testing to Evaluate the Retention of Abuse-Deterrent Properties of Polyethylene Oxide Matrix Tablets

Cited by 9 publications

References 37 publications

A Novel Use of Nanocrystalline Suspensions to Develop Sub-Microgram Dose Micro-Tablets

A Novel Use of Nanocrystalline Suspensions to Develop Sub-Microgram Dose Micro-Tablets

Central Composite Design Assisted Formulation Development and Optimization of Gastroretentive Floating Tablets of Dextromethorphan Hydrobromide

Preferential Oxycodone Loss of Physically Manipulated Abuse Deterrent Oxycodone HCl Extended Release Tablets Prepared for Nasal Insufflation Studies

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