Use of Early Biomarkers in Neonatal Brain Damage and Sepsis: State of the Art and Future Perspectives

Bersani, Iliana; Auriti, Cinzia; Ronchetti, Maria Paola; Prencipe, Giusi; Gazzolo, Diego; Dotta, Andrea

doi:10.1155/2015/253520

Cited by 23 publications

(14 citation statements)

References 106 publications

(110 reference statements)

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“…To date, neonatal sepsis represents a major complication of the neonatal period with an increased risk of death among either preterm or term neonates. 17 Sepsis is defined as an uncontrolled immune and inflammatory response to an infectious injury, resulting in OS, a devastating production of pro-inflammatory cytokines, and massive mitochondrial dysfunction. The role of damage to mitochondria in the pathophysiology of sepsis and the subsequent organ dysfunction is widely accepted.…”

Section: Neonatal Sepsis and Oxidative Stressmentioning

confidence: 99%

Melatonin and Neonatal Sepsis: A Promising Antioxidant Adjuvant Agent

et al. 2017

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Sepsis represents a major clinical problem in neonatal setting with elevated mortality rate related to multiple organ failure. Despite decades of research, the exact mechanism of organ failure in sepsis is still not completely understood. Oxidative stress (OS), derived from an imbalance between pro-oxidant and antioxidant factors, is involved in the pathogenesis of several neonatal diseases, including sepsis, and plays a particular role in systemic organ failure. Recently, it has been recognized that administration of antioxidants could be useful in septic patients. Among all antioxidants, melatonin has a characteristic role as an antioxidant, anti-inflammatory, and anti-apoptotic agent. In combination with other interventions, melatonin may contribute to an improvement in septic organ injury. Furthermore, melatonin has already been widely used in treating various diseases of neonatal population, including asphyxia, respiratory distress, and sepsis, and no significant toxicity or treatment-related side effects with long-term melatonin therapy have been reported. This review aims to summarize current knowledge concerning the potential beneficial role of melatonin in septic neonates, supporting its short-term adjuvant co-therapy to reduce complications during neonatal sepsis

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Section: Neonatal Sepsis and Oxidative Stressmentioning

confidence: 99%

Melatonin and Neonatal Sepsis: A Promising Antioxidant Adjuvant Agent

et al. 2017

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“…There has been a dramatic increase in recent years in the number of studies focusing on neurobiomarkers (NBs) of central nervous system (CNS) injury [1][2][3][4][5][6][7][8][9][10][11]. The optimal NB should be reliable, easily and harmless to collect, reproducible and able to guide caregivers in daily practice.…”

Section: Introductionmentioning

confidence: 99%

Early predictors of perinatal brain damage: the role of neurobiomarkers

Bersani

Pluchinotta

Dotta

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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The early detection of perinatal brain damage in preterm and term newborns (i.e. intraventricular hemorrhage, periventricular leukomalacia and perinatal asphyxia) still constitute an unsolved issue. To date, despite technological improvement in standard perinatal monitoring procedures, decreasing the incidence of perinatal mortality, the perinatal morbidity pattern has a flat trend. Against this background, the measurement of brain constituents could be particularly useful in the early detection of cases at risk for short-/long-term brain injury. On this scenario, the main European and US international health-care institutions promoted perinatal clinical and experimental neuroprotection research projects aimed at validating and including a panel of biomarkers in the clinical guidelines. Although this is a promising attempt, there are several limitations that do not allow biomarkers to be included in standard monitoring procedures. The main limitations are: (i) the heterogeneity of neurological complications in the perinatal period, (ii) the small cohort sizes, (iii) the lack of multicenter investigations, (iv) the different techniques for neurobiomarkers assessment, (iv) the lack of consensus for the validation of assays in biological fluids such as urine and saliva, and (v), the lack of reference curves according to measurement technique and biological fluid. In the present review we offer an up-to-date overview of the most promising developments in the use of biomarkers in the perinatal period such as calcium binding proteins (S100B protein), vasoactive agents (adrenomedullin), brain biomarkers (activin A, neuron specific enolase, glial fibrillary acidic protein, ubiquitin carboxyl-terminal hydrolase-L1) and oxidative stress markers.

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“…En la asfixia perinatal diversos estudios encuentran niveles mayores de MDA y nitratos que tendrían correlación con la morbilidad y la mortalidad (7,8) . Asimismo, el uso de oxitocina estaría asociado con eventos adversos neonatales (9)(10)(11) como altos niveles de lactato (9) y bajos niveles de glutation (12) , aunque con valores variables de MDA (12,13) . La proteína S100B es producida y liberada por los astrocitos en el sistema nervioso central donde tiene funciones tróficas en las neuronas y la glía, la acumulación de esta por secreción o liberación de astrocitos dañados a nivel extracelular guiaría a un daño neuronal con producción de citoquinas proinflamatorias (14) , siendo un marcador útil para evaluar el daño neuronal, en distintas patologías como la encefalopatía hipóxica isquémica (11,15,16) o hemorragia intraventricular (11) .…”

Section: Mensajes Claveunclassified

Efecto de la oxitocina en los niveles de malondialdehído, óxido nítrico y proteína S100B en el recién nacido

Condori-Merma

Moreno-Loaíza

Paz-Aliaga

et al. 2018

Rev Peru Med Exp Salud Publica

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Objetivos. Evaluar los efectos de la administración de oxitocina en la conducción del parto en los niveles de malondialdehído (MDA), óxido nítrico (ON) y proteína S100B en el recién nacido. Material y Métodos. Se seleccionó a 80 gestantes a término sin patología obstétrica y fetal, formando dos grupos: Gestantes con parto normal y conducidas con oxitocina. Se extrajo sangre inmediatamente después del parto de la vena de cordón umbilical para medir MDA, ON y de la arteria para la proteína S100B. Se cuantificó la concentración de MDA y ON por métodos espectroscópicos y la proteína S100B por ELISA. Resultados. Se tuvo valores de 3,4 uMol/L y 3,6 uMol/L de MDA y 1,4 uMol/Ly 1,8 uMol/L de ON en el grupo conducido con oxitocina y control respectivamente sin diferencia significativa, los niveles de S100B fueron mayores en el grupo conducido con oxitocina, con una mediana de 1,36 μg/L comparado con el grupo de parto normal 1,11 μg/L (p=0,03). No hubo relación entre la dosis de oxitocina administrada y los niveles de MDA, ON y S100B. Conclusiones. No hay diferencia entre los niveles de MDA y ON entre las gestantes con parto normal y conducidas. Hay diferencia significativa en los niveles de proteína S100B en recién nacidos de parto con oxitocina. No hay relación entre la dosis de oxitocina y los niveles de estrés oxidativo y proteína S100B.

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Use of Early Biomarkers in Neonatal Brain Damage and Sepsis: State of the Art and Future Perspectives

Cited by 23 publications

References 106 publications

Melatonin and Neonatal Sepsis: A Promising Antioxidant Adjuvant Agent

Melatonin and Neonatal Sepsis: A Promising Antioxidant Adjuvant Agent

Early predictors of perinatal brain damage: the role of neurobiomarkers

Efecto de la oxitocina en los niveles de malondialdehído, óxido nítrico y proteína S100B en el recién nacido

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