Use of electrical impedance spectroscopy to&amp;nbsp;detect malignant and potentially malignant&amp;nbsp;oral&amp;nbsp;lesions

Murdoch, Craig; Brown, Brian; Hearnden, Vanessa; Speight, Paul M.; D’Apice, Katy; Hegarty, Anne M; Tidy, John; Healey, Timothy J.; Highfield, Peter E.; Thornhill, Martin H.

doi:10.2147/ijn.s64087

Cited by 40 publications

(32 citation statements)

References 35 publications

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“…This index value is determined by calculating the match to a stored template that was determined from 3-D finite element, cellular-level, modelling of the structure of high grade CIN epithelium. This structure was determined by measurements made from histopathology images of diseased tissue [ 7 , 8 ]. The calculated index of probability is used to guide the clinician in taking a diagnostic biopsy.…”

Section: Methodsmentioning

confidence: 99%

Prognostic value of Electrical Impedance Spectroscopy (EIS) when used as an adjunct to Colposcopy – a longitudinal study

Brown

Highfield²,

Tidy

2020

Journal of Electrical Bioimpedance

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ObjectiveColposcopy can be used with Electrical Impedance Spectroscopy (EIS) as an adjunct, to assess the presence of High Grade Cervical Intra-epithelial Neoplasia (CIN2+). This analysis of longitudinal data has used the results from women with a negative colposcopy, in order to see if the initial (index) EIS results were able to predict the women who subsequently developed CIN2+. A further objective was to investigate what tissue structural changes might be reflected in the electrical impedance spectra.Methods847 patients were referred with low grade cytologly. EIS measurements were made around the transformation zone of the cervix during colposcopy. Every EIS spectrum was matched to a template representing CIN2+ and the result was positive if the match exceeded a probability index threshold. The colposcopic impression was also recorded. All the women who developed biopsy proven CIN2+ within three years of the index colposcopy were identified.ResultsThe median follow-up was 30.5 months. Where both CI and EIS were initially positive, there was an increased prevalence (8.13%) of CIN2+ developing as opposed to 3.45% in the remaining patients (p=0.0159). In addition, if three or more EIS spectra were positive there was a higher prevalence (9.62% as opposed to 3.56% p=0.0132) of CIN2+ at three years. The index spectra recorded from the women who developed CIN2+ showed EIS changes consistent with increases in the extracellular volume and in cell size inhomogeneity.ConclusionEIS does offer prognostic information on the risk of CIN2+ developing over the three-year period following the EIS measurements. The changes in EIS spectra are consistent with an increase in cell size diversity as pre-malignancy develops. These changes may be a consequence of increased genetic diversity as neoplasia develops.

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Section: Methodsmentioning

confidence: 99%

Prognostic value of Electrical Impedance Spectroscopy (EIS) when used as an adjunct to Colposcopy – a longitudinal study

Brown

Highfield²,

Tidy

2020

Journal of Electrical Bioimpedance

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“…Included studies (Table 1) were published between 2006 and 2020, and they were focused on the Autofluorescence technique (n:14) [28][29][30][31][32][33][34][35][36][37][38][39][40][41], HRME (n:5) [42][43][44][45][46], Optical spectroscopy (n:7) [10, [47][48][49][50][51][52], NBI (n:2) [53,54], and Vital Stain Colorants (n:6) [55][56][57][58][59][60]. In total, 34 studies were performed in adults (18 years of age or older).…”

Section: Study Characteristicsmentioning

confidence: 99%

In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders—Systematic Review and Meta-Analysis

Mazur

Ndokaj

Venugopal

et al. 2021

IJERPH

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Objectives: Oral potentially malignant disorders (OPMDs) are lesions that may undergo malignant transformation to oral cancer. The early diagnosis and surveillance of OPMDs reduce the morbidity and mortality of patients. Diagnostic techniques based on medical images analysis have been developed to diagnose clinical conditions. This systematic review and meta-analysis aimed to evaluate the efficacy of imaging-based techniques compared to the gold standard of histopathology to assess their ability to correctly identify the presence of OPMDs. Design: Literature searches of free text and MeSH terms were performed using MedLine (PubMed), Scopus, Google Scholar, and the Cochrane Library (from 2000 to 30 June 2020). The keywords used in the search strategy were: (“oral screening devices” or “autofluorescence” or “chemiluminescence” or “optical imaging” or “imaging technique”) and (“oral dysplasia” or “oral malignant lesions” or “oral precancerosis”). Results: The search strategy identified 1282 potential articles. After analyzing the results and applying the eligibility criteria, the remaining 43 papers were included in the qualitative synthesis, and 34 of these were included in the meta-analysis. Conclusions: None of the analyzed techniques based on assessing oral images can replace the biopsy. Further studies are needed to explore the role of techniques-based imaging analysis to identify an early noninvasive screening method.

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“…EIS has been applied to many clinical applications. Such as thyroid cancer diagnosis [6], skin cancer diagnosis [7], cardiopulmonary system diagnosis [8,9], cervical cancer diagnosis [10], prostate cancer diagnosis [11], and oral cancer diagnosis [12]. Based on the dielectric properties of benign thyroid lesions, EIS has the ability to differentiate morphological tissues and functional imaging, which is suitable for the classification of thyroid nodules.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of electrical characteristics of biological tissue with electrical impedance spectroscopy

Yao

Wang

et al. 2020

Electrophoresis

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The electrical characteristics of biological tissue is evaluated by establishing an electrical equivalent circuit with electrical impedance spectroscopy. The least squares method is used to realize electrical equivalent circuit fitting by using the developed portable electrical impedance spectroscopy system. The EIS system is used to obtain the impedance spectrum data of the measured biological tissue. In the experiment, the impedance spectrum data of eggs under different heating time were measured, and the established equivalent circuit model of eggs was fitted by nonlinear least squares fitting algorithm. Moreover, the electrical characteristics of the biological tissue are also revealed by numerical simulation with HANAI model. The experimental and simulation results show that the extracted equivalent electrical parameters can clearly characterize the variation of the internal change of components of biological tissues.

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Use of electrical impedance spectroscopy to detect malignant and potentially malignant oral lesions

Cited by 40 publications

References 35 publications

Prognostic value of Electrical Impedance Spectroscopy (EIS) when used as an adjunct to Colposcopy – a longitudinal study

Prognostic value of Electrical Impedance Spectroscopy (EIS) when used as an adjunct to Colposcopy – a longitudinal study

In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders—Systematic Review and Meta-Analysis

Evaluation of electrical characteristics of biological tissue with electrical impedance spectroscopy

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