Use of Electronic Health Records at Federally Qualified Health Centers: a Potent Tool to Increase Viral Hepatitis Screening and Address the Climbing Incidence of Liver Cancer

Pham, Christina; Sin, Mo-Kyung

doi:10.1007/s13187-020-01741-1

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…The evidence presented in the literature showed that reminders in an EHR positively affect prescribing behaviors, mainly when it comes to appropriately screening patients for hepatitis C (Mulhem et al, 2020). It also revealed potential problems with this proposal, such as alert fatigue and provider tendency to override alerts (Pham & Sin, 2021). Knowledge of these potential problems allows for necessary adjustments to address the issue.…”

Section: Review Of Literaturementioning

confidence: 99%

The effect of discharge care plans on statin prescription rates

Alleyne

2023

J Am Assoc Nurse Pract

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Background:Stroke discharge care bundles have been proposed to address inadequate provider statin prescription rates.Local problem:Discontinuation of statins has been associated with a 37% relative risk increase in mortality in patients with a stroke diagnosis. The project site had a statin prescription rate of 86.2%.Methods:The project was initiated at a 641-bed regional community teaching medical center. Statin prescription rates upon discharge on patients with the diagnosis of transient ischemic attack or stroke were evaluated and noted to be below the benchmark of 95%. Possible interventions to improve this benchmark were discussed with key stakeholders such as the information technology team, stroke care outcomes team, and neurology service providers. The proposed intervention was incorporated into the electronic health record. Provider prescription rates were tracked monthly along with the use of the proposed intervention. A one-sided z-test was used to analyze the data collected.Interventions:A stroke discharge power plan within an electronic health record was modified to increase the rate of statin prescriptions. The key modification included checking off the prescription of a statin on discharge. Reinforcement of its use was done through monthly reminders.Results:Use of discharge care plan yielded 100% compliance. Overall compliance was 9.7%. The null hypothesis of the one-sided z-test was 89%. The p-value for all tests was <0.05.Conclusion:The use of a stroke discharge care plan within an electronic health record can positively affect secondary stroke prevention by increasing statin prescription rates.

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Section: Review Of Literaturementioning

confidence: 99%

The effect of discharge care plans on statin prescription rates

Alleyne

2023

J Am Assoc Nurse Pract

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“…In the United States, chronic HBV is more likely to affect vulnerable populations and minorities. Studies have demonstrated that Asian Americans, Pacific Islanders, and Blacks-particularly foreign-born Blacks-have higher rates of hepatitis B infections [30,31]. In addition, Asian and Pacific Islanders have the highest incidence rate of HCC and HCC-related mortality [32].…”

Section: Almentioning

confidence: 99%

Pregnancy and Hepatitis B Immunization: A Commentary on Maternal Knowledge and Vertical Transmission Risks

2021

Archives of Gastroenterology Research

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“…The highest incidence (mortality) of liver cancer is in East Asia, accounting for 35.5% of the global total. The main risk factors for liver cancer are chronic hepatitis B virus (HBV) [2][3][4], hepatitis C virus (HCV) [5][6][7], a atoxincontaminated food [8], heavy alcohol consumption [6,9,10], obesity [11], smoking [12] and type 2 diabetes [13,14]. According to statistics, the risk factors of liver cancer formation are different in 53 countries and regions in the world.…”

Section: Introductionmentioning

confidence: 99%

Screening of Early Diagnostic Biomarkers and Prognostic Biomarkers for Liver Cancer Based on GEO and TCGA Databases and Studies on Pathways and Biological Functions Affecting the Survival Time of Liver Cancer

Gao

Gang

Tan

2020

Preprint

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BackgroundLiver cancer is the sixth most common diagnosed cancer, and the fourth most common cause of cancer death in the world. Currently, the most commonly used diagnostic marker in clinical practice is alpha-fetoprotein(AFP), but its diagnostic accuracy is low. At the same time, the prognosis of liver cancer patients is of great significance to the determination of the diagnosis and treatment of liver cancer and the improvement of the quality of life of the patients. Therefore, the purpose of this paper is to find new diagnostic markers and prognostic markers of liver cancer and to explore the pathways and biological functions related to the prognosis of liver cancer. MethodsWe firstly obtained the GSE25097 dataset and the the Cancer Genome Atlas(TCGA) datasets respectively and then analysed the differentially expressed genes(DEGs). To study the potential biological function of DEGs, we conducted enrichment analysis of GO biological functions and the Reactome pathway with R language. We used protein-protein interaction network analysis to identify the relationship among these common DEGs(Common DEGs), and further screened out the hub genes among these Common DEGs. We used ROC curve analysis to screen the hub genes to determine the genes that could be used as diagnostic markers of liver cancer. Kaplan-Meier analysis and Cox proportional hazards model were used to screen genes associated with prognosis of liver cancer, and further single-gene GSEA(gene set enrichment analysis) was performed on the prognosis genes to explore the mechanism affecting the survival and prognosis of liver cancer patients. ResultsWe obtained 790 DEGs and 2162 DEGs respectively from the GSE25097 and TCGA LIHC data sets, and get 102 Common DEGs by overlapping the two DEGs. We screened 22 hub genes from 102 Common DEGs. We used ROC curve and survival curve to analyze these 22 Hub genes, and found that there were 16 genes with the AUC > 90%, among which the expression levels of ESR1,SPP1 and FOSB genes were closely related to the survival time of liver cancer patients. We revealed all the related pathways of ESR1, FOSB and SSP1 genes by using single-gene GSEA analysis, and found three common pathways of ESR1, FOBS and SPP1 genes, seven common pathways of ESR1 and SPP1 genes, and four common pathways of ESR1 and FOSB genes.Conclusionwe found that ten genes with high expression in the liver cancer, including SPP1, AURKA, NUSAP1, TOP2A, UBE2C, AFP, GMNN, PTTG1, RRM2 and SPARCL1, and six genes with low expression, including CXCL12, FOS, DCN, SOCS3, FOSB and PCK1, can be used as markers of liver cancer diagnosis, among which FOBS and SPP1 genes can also be used as prognostic markers of liver cancer. Activation of the cell cycle-related pathway, PANCREAS BETA CELLS pathway, and the estrogen signalling pathway in LIVER CANCER patients, while inhibition of the HALLMARK HEME METABOLISM pathway, HALLMARK COAGULATION pathway, and the fat metabolism pathway may promote the prognosis in LIVER CANCER patients.

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Use of Electronic Health Records at Federally Qualified Health Centers: a Potent Tool to Increase Viral Hepatitis Screening and Address the Climbing Incidence of Liver Cancer

Cited by 8 publications

References 19 publications

The effect of discharge care plans on statin prescription rates

The effect of discharge care plans on statin prescription rates

Pregnancy and Hepatitis B Immunization: A Commentary on Maternal Knowledge and Vertical Transmission Risks

Screening of Early Diagnostic Biomarkers and Prognostic Biomarkers for Liver Cancer Based on GEO and TCGA Databases and Studies on Pathways and Biological Functions Affecting the Survival Time of Liver Cancer

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