Use of electrospinning technique for biomedical applications

Whole-organ engineering with natural extracellular materials

“…The ability to electrospin natural materials offers the benefits of incorporated peptide motifs that synthetic materials lack, although natural materials can be too weak to form reproducible nanofibers, and are therefore often blended with biocompatible, synthetic polymers to create composite fibers with added strength [40]. Furthermore, the addition of natural polymers to synthetic fibers has improved the adhesion, viability and proliferation over synthetic material alone [41,42].…”

“…Crosslinkers are used to strengthen spun fibers and render natural fibers more water resistant [42]. Some natural-spun fibers have circumscribed or reduced cytotoxic solvent or crosslinker usage by using techniques such as melt electrospinning, or by replacing organic solvents and crosslinkers with less toxic alternatives [40,43,52,53].…”

Electrospun Herbal Extract Derived Polymer Nanocomposites for Medical Applications

“…The advantages of electrospinning in production of wounddressing materials are: oxygen permeation, protection of wound from infection and dehydration and homogenous scaffold (6). Many synthetic and natural polymers (carboxyethyl chitosan/PVA, collagen/chitosan, silk fibroin, ABA type poly(dioxanoneco-L-lactide)-block-poly(ethylene glycol) (PPDO/PLLA-b-PEG) block copolymer) have been electrospun for wound-dressing applications (21).…”

“…Many synthetic and natural polymers (carboxyethyl chitosan/PVA, collagen/chitosan, silk fibroin, ABA type poly(dioxanoneco-L-lactide)-block-poly(ethylene glycol) (PPDO/PLLA-b-PEG) block copolymer) have been electrospun for wound-dressing applications (21). In vitro culture studies of human dermal fibroblasts on electrospun PCL collagen blend nanofibrous membranes are shown to be promising as dermal substitute for the treatment of skin defects and burn wounds (6).…”

“…The effectiveness of this method has been also scientifically proven in several biomedical applications such as tissue engineering, drug release, enzyme immobilization, etc. (6). To produce electrospun nanofibers web, a solution of polymer and extract spinning solution is used.…”