Use of enhanced external counterpulsation in the treatment and rehabilitation of patients with atherosclerosis obliterans of the lower extremity

Badtieva, V A; Voroshilova, D. N.; Сичинава, Н В

doi:10.17116/kurort2019960415

Cited by 7 publications

(2 citation statements)

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“…Surveys show that the incidence of peripheral arterial ischemic disease among people over 70 years old is approximately 15%-20% in western countries, while it reaches 15.91% in China [ 6 , 7 ]. Not only that, limb ischemia triggered by LEASO causes a soaring disability and mortality, which seriously worsens the prognosis of patients [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy of Interventional Therapy on Lower Extremity Arteriosclerosis Obliterans and Prognostic Factors

Xiao

Song

2022

Computational and Mathematical Methods in Medicine

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Objective. This study was designed to analyse the clinical efficacy of interventional therapy on lower extremity arteriosclerosis obliterans (LEASO) and prognostic factors. Methods. A total of 122 patients with LEASO diagnosed in our hospital from March 2017 to March 2019 were retrospectively analysed. Among them, 72 patients who received conservative therapy were assigned to a conservative group, and 50 patients who received interventional therapy additionally based on conservative therapy were assigned to an intervention group. The short-term (12 weeks after therapy) and long-term (3 years after therapy) clinical efficacies on the two groups were compared. Death, amputation, and vascular restenosis ( vascular stenosis > 50 % in computed tomography reexamination) were defined as unfavourable outcomes, and Cox regression was conducted to analyze the factors influencing the prognosis of patients. The incidence of adverse events in the two groups within 3 years was compared and statistically analyzed. Additionally, the hospital stay, therapy cost, claudication distance, and ankle brachial index were compared between the two groups. Results. After therapy, the conservative group showed a notably lower total effective rate than the intervention group ( P < 0.05 ), but the clinical efficacy after 3 years was similar between the two groups ( P > 0.05 ). Additionally, the conservative group experienced notably longer hospital stay than the intervention group ( P < 0.05 ), and cost less in treatment than the intervention group ( P < 0.05 ). However, the conservative group experienced a notably shorter claudication distance and showed a notably lower ankle brachial index than the intervention group ( P < 0.05 ). The two groups were not significantly different in mortality, amputation rate, and vascular restenosis rate ( P > 0.05 ). Moreover, Cox regression analysis revealed that age and conservative therapy were independent risk factors for the prognosis of patients ( P < 0.05 ). Conclusion. Interventional therapy can substantially improve the short-term efficacy and prognosis of patients with LEASO, but the cost is high, so the therapeutic regimen should be selected according to the patient’s economic condition.

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Section: Introductionmentioning

confidence: 99%

Clinical Efficacy of Interventional Therapy on Lower Extremity Arteriosclerosis Obliterans and Prognostic Factors

Xiao

Song

2022

Computational and Mathematical Methods in Medicine

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“…In certain instances, individuals afflicted with LE-PAD manifest pronounced limb ischemia and tissue necrosis attributable to the absence of systematic follow-up care. This deficiency culminates in the imperative requirement for limb amputation and, in certain scenarios, leads to mortality, primarily caused by sepsis, multiple organ failure, and assorted complications [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Construction of a novel lower-extremity peripheral artery disease subtype prediction model using unsupervised machine learning and neutrophil-related biomarkers

Zhang,

Ma,

et al. 2024

Heliyon

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Association Between Thromboelastography and Coagulation for Disease Severity Evaluation in Patients With Lower Extremity Arteriosclerosis Obliterans

Huang,

Feng,

Bai

et al. 2024

Clinical Laboratory Analysis

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BackgroundThromboelastography (TEG) and coagulation tests can be used to detect hypercoagulability to assess thrombus formation. This study explored the association between TEG and coagulation in evaluating disease severity in elderly patients with lower extremity arteriosclerotic occlusive disease (LEASO), aimed to provide surgical treatment guideline.MethodsWe retrospectively analyzed the clinical characteristics, laboratory biomarkers, TEG and coagulation parameters of 233 elderly LEASO patients treated between 2020 and 2023. Among them, 86 underwent surgical amputation, 51 received vascular intervention, and the remaining were treated conservatively. Differences in TEG and coagulation among the three groups were assessed using Spearman's correlation. Multivariate logistic regression and receiver operating characteristic curves analyzed the relationships among TEG, fibrinogen (FIB), and D‐dimer (D‐D) levels for surgical evaluation.ResultsInflammatory factors, platelet counts, and Fontaine stages III‐IV differed significantly between the surgery and conservative groups (p < 0.05). The surgery group had higher α‐angle, maximum amplitude (MA), coagulation comprehensive index (CI), FIB, and D‐D, whereas lower clotting time (K) compared to the conservative group (p < 0.05), correlated with a lower ankle brachial index (ABI), indicating more severe clinical presentation. Spearman's analysis identified positive associations between α‐angle, MA with FIB and D‐D levels in surgical patients. Area under curve analysis indicated that combining MA, α‐angle, FIB, and D‐D could enhance accuracy in evaluating surgical necessity in LEASO.ConclusionIn elderly LEASO patients, TEG and coagulation analysis revealed a positive association between thrombus intensity and disease severity. Increased MA, α‐angle, FIB, and D‐D levels serve as predictors for surgical treatment necessity in LEASO.

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Use of enhanced external counterpulsation in the treatment and rehabilitation of patients with atherosclerosis obliterans of the lower extremity

Cited by 7 publications

References 1 publication

Clinical Efficacy of Interventional Therapy on Lower Extremity Arteriosclerosis Obliterans and Prognostic Factors

Clinical Efficacy of Interventional Therapy on Lower Extremity Arteriosclerosis Obliterans and Prognostic Factors

Construction of a novel lower-extremity peripheral artery disease subtype prediction model using unsupervised machine learning and neutrophil-related biomarkers

Association Between Thromboelastography and Coagulation for Disease Severity Evaluation in Patients With Lower Extremity Arteriosclerosis Obliterans

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