Use of equine chorionic gonadotropin in lactating dairy cattle: a rapid review

Beasley, LH; Cogger, Naomi; Compton, C.W.R.

doi:10.1080/00480169.2022.2139306

Cited by 4 publications

(3 citation statements)

References 56 publications

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“…The hormonal stimulating folliculogenesis is most developed in pig and cattle breeding (Cunha & Martins, 2022;Beasley et al, 2023). Most of those industries apply methods in rabbit breeding.…”

Section: Introductionmentioning

confidence: 99%

Histomorphology of the ovaries of rabbits does during ovulation induced by the combined use of gonadotropins

Tverdokhlib,

Naumenko,

Koshevoy

et al. 2024

Ukr. Jour. of Vet. and Agr. Sci.

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Hormonal stimulation of folliculogenesis is a general method of increasing reproductive capacity in rabbits; however, studying the safety of the developed protocols remains an urgent scientific task. The use of hormonal agents is due to the physiological characteristics of rabbits, primarily coitus-dependent mechanisms of ovulation. Applying gonadotropin-releasing analogs depends on mature follicles ready for ovulation in the ovary. It, therefore, has limited effectiveness for rabbits of the “zero” cycle that have not yet given birth. Therefore, such females are recommended to use medications based on gonadotropins obtained from the serum of foal mares (eCG) or human chorionic gonadotropin (hCG). There is limited data on the combined use of gonadotropins, especially the long-term administration in different doses. Thus, the research aimed to conduct a morphological evaluation of rabbit's ovaries with combined serum and chorionic gonadotropins to stimulate folliculogenesis before artificial insemination to assess the safety of the proposed dosages and long-term administration. Stimulation of ovulation in rabbits of experimental groups was caused by the combined use of serum and chorionic gonadotropins (eCG – 400 IU; hCG – 200 IU) for experimental groups 1 and 2 at a dose of 40 IU and 24 IU, respectively. Females of the control group were induced to ovulate by subcutaneous injection of 0.2 ml of gonadotropin-releasing hormone analog. Ovaries were collected on the seventh day of gestation after the euthanasia of the rabbit with prior premedication. After dissection and macroscopic examination, the ovaries were fixed in a 10% aqueous solution of neutral formalin. Histological slides were made according to the general method by pouring in paraffin and subsequent staining with hematoxylin and eosin. The research has established that repeated (during five reproductive cycles) combined use of serum and chorionic gonadotropins has dose-dependent effectiveness and can cause dysfunction of ovaries and blood circulation. Pathological changes may acquire a systemic character with the manifestation of critical conditions for the health and life of rabbits. The stimulating effect of the combined use of eCG and hCG was detected at a dose of 40 IU, and the inhibition of folliculogenesis was observed at 24 IU. Since the premises for the hyperandrogenism were found microscopically, it was essential to investigate the level of androgens in the blood of rabbits after using a dose of 24 IU. At the same time, both doses of gonadotropins affect the reactivity of the endothelium, which is manifested by the presence of intravascular vesicles and changes in the rheological properties of blood.

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Section: Introductionmentioning

confidence: 99%

Histomorphology of the ovaries of rabbits does during ovulation induced by the combined use of gonadotropins

Tverdokhlib,

Naumenko,

Koshevoy

et al. 2024

Ukr. Jour. of Vet. and Agr. Sci.

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“…However, several studies have indicated that good fertility owing to eCG treatment is limited in lactating dairy cows. Recently, Beasley et al summarized in a rapid review that the efficacy of eCG in improving the reproductive performance of lactating cows has been inconsistent [18]. Garcia-Ispierto et al reported that eCG treatment of dairy cows without signs of estrus could improve fertility [19,20].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Beasley et al . summarized in a rapid review that the efficacy of eCG in improving the reproductive performance of lactating cows has been inconsistent [ 18 ]. Garcia-Ispierto et al .…”

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confidence: 99%

Equine chorionic gonadotropin treatment and timed artificial insemination for dairy cow production under heat stress

FUNAKOSHI,

SHIOTANI,

SEKI

2024

Journal of Reproduction and Development

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This study investigated the effects of timed artificial insemination (TAI) and equine chorionic gonadotropin (eCG) administration on lactating dairy cows under heat-stress conditions (average temperature-humidity index: 80). Timed artificial insemination was performed on the cows with (n = 57) or without (control, n = 41) supplementation with 500 IU of eCG at the day of PGF 2α treatment using the CIDR-Ovsynch protocol. GnRH was administered, and a progesterone device (CIDR) was inserted on Day −10 of the treatment protocol. The CIDR was removed on Day −3, and the cows were treated with PGF 2α . Two days later, a 2 nd GnRH injection was administered. Subsequently, AI was performed on Day 0 (16–20 h after the 2 nd GnRH injection), and pregnancy was diagnosed on Days 32 and 60. Plasma progesterone (P 4 ) concentrations were measured after AI. Results showed that the eCG group had a higher pregnancy per AI (P/AI) than the control group (43.9 vs . 12.2%, P = 0.002), which was also accompanied by elevated P 4 levels. Four cows in the eCG group had multiple calves, representing 7.0 and 16.0% of the group and pregnant cows, respectively. In conclusion, 500 IU of eCG combined with CIDR-Ovsynch in lactating dairy cows under severe heat stress conditions successfully improved fertility. However, the protocol may have a slight risk of multiple births.

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Clinical value of chorionic gonadotropin and progesterone combined with transvaginal ultrasound in the diagnosis of threatened abortion

Zhang

2024

Journal of Radiation Research and Applied Sciences

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Use of equine chorionic gonadotropin in lactating dairy cattle: a rapid review

Cited by 4 publications

References 56 publications

Histomorphology of the ovaries of rabbits does during ovulation induced by the combined use of gonadotropins

Histomorphology of the ovaries of rabbits does during ovulation induced by the combined use of gonadotropins

Equine chorionic gonadotropin treatment and timed artificial insemination for dairy cow production under heat stress

Clinical value of chorionic gonadotropin and progesterone combined with transvaginal ultrasound in the diagnosis of threatened abortion

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