Use of Esophageal pH Monitoring to Minimize Proton-Pump Inhibitor Utilization in Patients with Gastroesophageal Reflux Symptoms

Triadafilopoulos, George; Zikos, Thomas; Regalia, Kirsten; Sonu, Irene; Fernandez‐Becker, Nielsen; Nguyen, Linda Anh B.; Nandwani, Monica; Clarke, John O.

doi:10.1007/s10620-018-5183-4

Cited by 7 publications

(1 citation statement)

References 28 publications

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“…In this study, the mean score of FSSG was moderately in height (17.20 ± 8.40). The results of this analysis are in line with the earlier studies presented by Miyamoto et al Conferring to the study of Miyamoto et al 21 . A high score of FSSG develops to be an aspect related with the PPI monotherapy failure.…”

Section: Discussionsupporting

confidence: 92%

A Prospective Observational Study Combinition of Proton Pump Inhibitors with Prokinetics in Gerd

Mushtaq¹,

Adeel²,

Hussain³

et al. 2022

PJMHS

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Background: Gastroesophageal reflux disease (GERD), a fairly common ailment that has a negative influence on quality of life. 30- 40% of patients with GERD have an insufficient response to standard PPIs therapy. For subjects resistant to this PPI therapy, double the PPI dosage or switch to different PPIs, which may not be ideal. So, combination therapy with prokinetic agent will significantly improve GERD symptoms. Study Design: A prospective observational study. Place and Duration: In the Department of Medicine, Faisalabad Medical University, Faisalabad from May 2022 to July 2022. Material and methods: 130 patients with suggestive symptoms of GERD were included to evaluate overlap between GERD and delayed gastric emptying and to forecast the necessity for therapy in combination with prokinetic drugs using the Frequency Scale for the Symptoms of GERD (FSSG) score. Results: 17.20 ± 8.40 was the mean total score of FSSG. Of the 130 subjects, 106 (81.54%) patients have GERD symptoms with an overall FSSG score >8. 7.43 ± 4.08 was the mean reflux score, and 9.40 ± 5.30 was the mean dysmotility score. In this analysis, patients with GERD symptoms had high score of FSSG, the symptoms of dysmotility appeared to be the main symptom than acid reflux. Conclusions: Based on this analysis results, combination therapy with prokinetic and PPIs in the subgroups of subjects with high scores of FSSG improved GERD symptoms. Keywords: Dysmotility score, delayed gastric emptying, GERD and Reflux score.

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Section: Discussionsupporting

confidence: 92%