Use of expiratory CT images in the diagnosis and localisation of airway complications following lung transplantation

Abstract

DESCRIPTIONA 78-year-old man presented with dyspnoea and subacute decline in lung function several years after undergoing a left lung transplant for pulmonary fibrosis. He had a history of left anastomotic stenosis that had been treated for some time with a stent. Initially unclear whether his decline was associated with a recurrent anastomotic issue or whether he had developed another problem, such as chronic rejection (bronchiolitis obliterans), a CT scan of the chest was performed and showed a clear left lung on inspiratory views (figure 1 and video 1). Expiratory views, however, demonstrated normal emptying (uniformly increased attenuation) of the left lower lobe and lingula, but marked air trapping ( persistently decreased attenuation) in the apical, anterior, and posterior segments of the left upper lobe (figure 1 and video 1), consistent with a diagnosis of anastomotic malacia resulting in significantly impaired ventilation.This novel case demonstrates that CT images with expiratory views can help localise areas of obstruction as well as to differentiate between processes involving the large versus small airways. While many conditions involve a combination of large and small airways disease, the lung transplant population is distinct in that large airway (anastomotic) or small airway (bronchiolar) complications may occur in isolation of each other; therefore, the inclusion of expiratory views on a CT scan is of particular value in diagnosing and differentiating between these conditions. In bronchiolitis obliterans, expiratory obstruction appears patchy with scattered mosaic air trapping.1 Air trapping confined to certain lobes of the lung without a diffuse nature, as in this case is indicative of an anastomotic complication. This serves as a reminder of the value of expiratory views on a CT scan in the setting of a lung transplantation. Video 1 Narrated review of the inspiratory and expiratory CT scans.