Use of extracts of Picralima nitida bark in the treatment of experimental trypanosomiasis: A preliminary study

Wosu, L.O.; Ibe, Chibuike

doi:10.1016/0378-8741(89)90032-9

Cited by 34 publications

(15 citation statements)

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“…It is widely distributed in high deciduous forest of West and Central Africa. It is employed in African traditional medicine as antipyretic, antimalarial, aphrodisiac and for GIT disorders (Wosu and Ibe, 1989). Jatropha podagrica Hook is a shrub grown in West Africa gardens for its showy red flowers.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of three medicinal plant extracts against <i>Plasmodium falciparum</i> and selected microganisms

Falodun¹,

Imieje²,

Erharuyi³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: A great revival of scientific interests in drug discovery has been witnessed in recent years from medicinal plants for health maintenance. The aim of this work was to investigate three Nigerian medicinal plants collected in Nigeria for their in vitro antiplasmodial and antimicrobial activities. Materials and Methods: Extracts obtained from parts of Persea americana, Jatropha podagrica and Picralima nitida and their fractions were evaluated for in vitro antiprotozoal and antimicrobial activity. Result: The methanol extract of P. nitida demonstrated activity against chloroquine-sensitive and chloroquine-resistant P. falciparum clones with IC 50 values of 6.3 and 6.0 µg/mL, respectively. Methanol and chloroform extracts of P. americana seed showed antifungal activity against Cryptococcus neoformans IC 50 less than 8 and 8.211 µg/mL respectively. Finally, the petroleum ether extract of P. americana had activity against methicillinresistant Staphylococcus aureus (MRSA) with an IC 50 value of 8.7 µg/mL. Conclusion: The study revealed the antibacterial and antiplasmodial activities of the plants extracts at the tested concentrations.

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Section: Introductionmentioning

confidence: 99%

Evaluation of three medicinal plant extracts against <i>Plasmodium falciparum</i> and selected microganisms

Falodun¹,

Imieje²,

Erharuyi³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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“…Natural products (plants and animals) are important sources of new drugs because their derivatives are extremely useful as lead structures for synthetic modification and optimization of bioactivity (Sülsen et al, 2007). In furtherance of the efforts on sourcing for novel molecules from natural sources in combating African animal trypanosomosis, previous research on in vivo antitrypanosomal activity is very limited compared to the in vitro experiments, and in the few in vivo studies found in literature, no complete cure without relapses was recorded for plants such as Alstonia boonei bark, Annona senegalensis root, Morinda lucida leaves and Picralima nitida (Wosu and Ibe, 1989). Hence, this work was undertaken to screen selected Nigerian medicinal plants for in vivo antitrypanosomal activity.…”

Section: Introductionmentioning

confidence: 93%

Evaluation of antitrypanosomal and anti inflammatory activities of selected Nigerian medicinal plants in mice

Adelodun

Elusiyan²,

Olorunmola³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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. AbstractThe extracts of nine selected Nigerian medicinal plants were investigated on Trypanosoma brucei brucei infected mice. The antiinflammatory properties of hexane fraction of the most promising U. chamae extract was assessed by acute oedema of the mice paw model while the modulatory effect of the extract on Delayed-Type Hypersensitivity (DTH) response on in vivo leucocytes mobilization was evaluated. 'Dose-probing acute toxicity tests' established an oral and intraperitoneal LD 50 for T. ivorensis stem bark as >1600 < 5000 mg/kg and 100 mg/kg respectively, while the oral LD 50 of Uvaria. chamae was >5000 mg/kg. Extracts of Khaya senegalensis, Harungana madagascariensis, Terminalia ivorensis, Curcuma longa, Ocimum gratissimum and Alcornea cordifolia showed weak anti-trypanosomal effect and did not exhibit significant clearance in parasitemia at the test dose administered compared with the positive control (Diminal®). However, the leaf extract of U. chamae and its hexane fraction demonstrated a significant response (P < 0.01). The fraction at 1000 mg/kg inhibited oedema by 107%. Uvaria. chamae demonstrated both antitrypanosomal and anti-inflammatory properties by increasing the survival time of infected mice due to reduction in parasitemia caused by T. brucei brucei.

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“…Another plant, Plumeria rubra, which is also a member of the family Apocynaceae, has a well-established anti-fertility activity (Dabhadkar et al, 2012). Picralima nitida has also been shown to possess antidiarrheic (Kouitcheu et al, 2006;Kouitcheu, 2007), antidiabetic (Aguwa et al, 2001), analgesic (Duwiejua et al, 2002), opioid (Menzies et al, 1998), anti-plasmodial (Ezeamuzie et al, 1994), anti-microbial (Fakeye et al, 2004), anti-inflammatory (Obiri 1997;Duwiejua et al, 2002), anti-pyretic (François et al, 1996), trypanocidal (Wosu and Ibe 1989), as well as anti-leishmanial (Iwu et al, 1992) activities. The bark is also used to prepare remedies for male sexual impotence (Adjanohoun et al, 1996).…”

Section: Oestrogenic Activitymentioning

confidence: 99%

Effects of Ethanolic Fruit Extract of Picralima nitida (Stapf) on Conception and Estrogenicity in Female Albino Rats

2017

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In search for medicinal plants with renowned reputation of contraceptive and fertility-modulating ability, this work was designed to evaluate the effects of ethanolic fruit extract of Picralima nitida on conception and oestrogenicity using twentyone sexually mature and twenty-four sexually immature female Sprague Dawley rats respectively. For the anti-conceptive study, 0 mg/kg, 50 mg/kg and 500 mg/kg of the extract was administered from day 1to day 4 of gestation (7 rats per group). On the 20th day of gestation, percentage of pregnant females (PPF), live foetal number (LFN), corpora lutea number (CLN), resorbed embryo number (REN), foetal crown-rump length (FCRL) and fertility indices (FI) were evaluated. For the anti-estrogenic study, Groups 1 to 3 (ovariectomized immature female rats) received 0.1 mg/kg of Stilboestrol, 50 mg/kg of the extract, and 0.2 ml of paraffin respectively, once daily for four consecutive days. Group 4 comprised of sham-operated immature female rats with their ovaries intact. The extract elicited absolute conception failure in 42.86% of the treated animals. The extract significantly (p < 0.05) reduced the FCRL, LFN and FI, but increased the REN. Evaluation of the allometric weights of the uterine tissues, endometrial thickness and vaginal opening revealed that the extract at 50 mg/kg body weight was antioestrogenic in activity. Findings from this research strongly suggest that the ethanolic fruit extract of Picralima nitida possesses significant post-coital anti-fertility activity in rats, which could not be attributed to its oestrogenic activity.

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Use of extracts of Picralima nitida bark in the treatment of experimental trypanosomiasis: A preliminary study

Cited by 34 publications

References 1 publication

Evaluation of three medicinal plant extracts against <i>Plasmodium falciparum</i> and selected microganisms

Evaluation of three medicinal plant extracts against <i>Plasmodium falciparum</i> and selected microganisms

Evaluation of antitrypanosomal and anti inflammatory activities of selected Nigerian medicinal plants in mice

Effects of Ethanolic Fruit Extract of Picralima nitida (Stapf) on Conception and Estrogenicity in Female Albino Rats

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