Use of Fibrin Glue for Open Comminuted Nasal Bone Fractures

Abstract

Nasal bone fractures are the most common type of facial fracture. Closed reduction has been used as the standard treatment modality for nasal fractures for many years. In cases of nasal fracture with lacerations at the fracture sites, bioabsorbable/metallic plate or interfragment wire fixation can be used with accurate alignment through the openings created by the lacerations. However, in cases of severe comminuted nasal fractures that are difficult to drill and fix, this type of fixation may not be feasible. We performed in 5 patients open reduction with internal fixation through laceration openings using the biomaterial Greenplast (Greencross Corporation, Seoul, Republic of Korea; human plasma fibrinogen, thrombin, aprotinin, and calcium chloride) under general anesthesia. Both structural and aesthetic outcomes were satisfactory. Open reduction through laceration openings and internal fixation with fibrin glue under general anesthesia may be a simpler and more effective method than those currently in general use for the repair of complicated comminuted open nasal fractures.

Mussel-inspired hydrogel tissue adhesives for wound closure

“…12,13 In recent years, tissue adhesives have commercialized with signicant advantages such as decreasing foreign body reaction during wound healing procedure and no need for further removal. 14,15 Tissue adhesive systems have been used in dentistry, [16][17][18] orthopedics, [19][20][21] cardiovascular 22,23 as well as in ophthalmology, 24 traumatology, and otorhinolaryngology and also for plastic and maxillofacial surgical applications. 25,26 The advantages of hard tissue (e.g.…”

Adhesives for treatment of bone fractures: A review of the state-of-the art

“…Bone cements were mostly phosphate [13,14,25], polyalkenoate [28,29] or acrylate-based cement [12,15,16,[30][31][32][33], either alone or with the addition of fillers, to improve their properties. Types of glues used were fibrin glue [17][18][19][20], consisted of human fibrinogen, bovine thrombin and calcium chloride, and dental adhesives of different consistencies [15,21,22,33], but also bioinspired glues [23,24,26].…”

“…(a) Treatment of highly fragmented fractures [13,16] (b) Fixation of long bone fractures [14,15,21,22,25,[30][31][32] (c) Filling bone voids and defects [15,19,20,[27][28][29]32] (d) Promoting bone regeneration [11,12,27] (e) Preventing non-union [30] (f) Maintaining reduction of fracture fixation [17,18,26]…”

“…Apart from two articles which used bioglues in a clinical setting [17,18], the rest of the papers investigated the properties of bone adhesives in either in vitro or in vivo settings. In the clinical papers, neither complications nor side effects were discussed, while no cases of allergic reactions to bioglues were reported.…”

Effect of fibrin sealant in positioning and stabilizing microvascular pedicle: A comparative study

“…Currently they have been three major applications in plastic surgery: as hemostatic agent following debridement with or without skin grafting, as adhesive for skin grafts to improve graft survival at normally inaccessible sites and in other clinical situations, and for reducing the frequency of seromas and the need for drains following surgery (Currie et al, ; Fezza et al, ; Mabrouk et al, ; Mooney et al, ; Saltz et al, ; Vibe and Pless, ). They are useful in a wide range of clinical situations from aesthetic surgery including face lifts and ear reconstructions, to fracture management, skin grafting applications, and nerve conduits (Jeong et al, ; Kalbermatten et al, ; Mabrouk et al, ; Marchac et al, ). There are many studies in the literature examining the role of fibrin sealants in the field of microvascular surgery.…”