Use of Foreign Protein in the Treatment of Peripheral Vascular Diseases

The endovascular revolution stopped at the carotid bifurcation … or did it?

“…It is extraordinary to read some of his early work, such as his report on the use of typhoid vaccine injection to augment the microcirculation in young people with gangrene, likely secondary to what we would refer to today as thromboanginitis obliterans. 2 This paper was read before the annual meeting of the American Medical Association in 1928; it contributed to Allen's national stature as a leader in vascular disease management. Allen spent a large part of his professional career investigating the prophylaxis of pulmonary embolism and was the first to promulgate ligation of the superficial femoral vein in the prevention of pulmonary embolism.…”