Use of forensic investigations in anti-doping

Jan, Nicolas; Marclay, François; Schmutz, Natalie; Smith, Matt; Lacoste, Alain; Castella, Vincent; Mangin, Patrice

doi:10.1016/j.forsciint.2011.07.037

Cited by 11 publications

(6 citation statements)

References 9 publications

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“…Additional information involving DNA analysis would have been useful to provide evidence of the identity of the athlete who provided the suspicious urine sample. Nowadays, anti‐doping laboratories receive more and more requests to perform investigations on genetic material, such as DNA, contained in urine or blood samples to demonstrate the sample's origin and to deter any manipulation during the testing process forbidden in the WADA Code.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of longitudinal steroid profiles from male football players in UEFA competitions between 2008 and 2013

Baume

Geyer

Vouillamoz

et al. 2015

Drug Testing and Analysis

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Testosterone and related compounds are the most recurrent doping substances. The steroid profile, consisting of the quantification of testosterone and its metabolites, has been described as the most significant biomarker to detect doping with pseudo-endogenous anabolic steroids. The steroidal module of the Athlete Biological Passport (ABP) was launched by the World Anti-Doping Agency (WADA) in 2014. To assess the value of introducing the module to its anti-doping programme, the Union of European Football Associations (UEFA) decided to analyze retrospectively the steroid profile data of 4195 urine samples, collected from 879 male football players and analyzed in 12 WADA-accredited laboratories between 2008 and mid-2013. This study focused on the evaluation of T/E ratios. The coefficient of variation (CV) and the adaptive model were the two statistical models used to study the longitudinal follow-up. A CV of 46% was determined to be the maximal natural intra-individual variation of the T/E when the sequence consisted of single data points analyzed in different laboratories. The adaptive model showed some profiles with an atypical T/E sequence and also enabled an estimate of the prevalence of external factors impacting the T/E sequences. Despite the limitations of this retrospective study, it clearly showed that the longitudinal and individual follow-up of the T/E biomarker of the players is a good tool for target testing in football. UEFA has therefore decided to implement the steroidal module of the ABP from the start of the next European football season in September 2015. Copyright © 2015 John Wiley& Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Evaluation of longitudinal steroid profiles from male football players in UEFA competitions between 2008 and 2013

Baume

Geyer

Vouillamoz

et al. 2015

Drug Testing and Analysis

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“…Since such issues correspond closely to criminal cases under forensic investigations, urine samples are collected in and out of competitions and exposed to a variety of analytical examinations developed to monitor the presence of a banned substance. 4,5 The WADA rules classify b 2 -agonists such as bambuterol HCl (BAM) and terbutaline (TER) as stimulants and anabolic agents with a restricted specic regulation. 3 Athletes oen use BAM for therapeutic purposes as a treatment for exercise-induced asthma.…”

Section: Introductionmentioning

confidence: 99%

Chemical fingerprinting and quantitative monitoring of the doping drugs bambuterol and terbutaline in human urine samples using ATR-FTIR coupled with a PLSR chemometric tool

et al. 2020

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“…Forensic analysis approaches are also applicable for anti-doping purposes to determine doping with performance-enhancing drugs, stimulants, steroids, and corticosteroids [26,27,28,29,30]. Ozgur et al developed a mass sensitive sensor for real time estradiol detection.…”

Section: Imprinting Approaches For Forensic Sciencementioning

confidence: 99%

Molecular Imprinting Applications in Forensic Science

Yılmaz

Gari̇pcan

Uzun

2017

Sensors

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Producing molecular imprinting-based materials has received increasing attention due to recognition selectivity, stability, cast effectiveness, and ease of production in various forms for a wide range of applications. The molecular imprinting technique has a variety of applications in the areas of the food industry, environmental monitoring, and medicine for diverse purposes like sample pretreatment, sensing, and separation/purification. A versatile usage, stability and recognition capabilities also make them perfect candidates for use in forensic sciences. Forensic science is a demanding area and there is a growing interest in molecularly imprinted polymers (MIPs) in this field. In this review, recent molecular imprinting applications in the related areas of forensic sciences are discussed while considering the literature of last two decades. Not only direct forensic applications but also studies of possible forensic value were taken into account like illicit drugs, banned sport drugs, effective toxins and chemical warfare agents in a review of over 100 articles. The literature was classified according to targets, material shapes, production strategies, detection method, and instrumentation. We aimed to summarize the current applications of MIPs in forensic science and put forth a projection of their potential uses as promising alternatives for benchmark competitors.

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Use of forensic investigations in anti-doping

Cited by 11 publications

References 9 publications

Evaluation of longitudinal steroid profiles from male football players in UEFA competitions between 2008 and 2013

Evaluation of longitudinal steroid profiles from male football players in UEFA competitions between 2008 and 2013

Chemical fingerprinting and quantitative monitoring of the doping drugs bambuterol and terbutaline in human urine samples using ATR-FTIR coupled with a PLSR chemometric tool

Molecular Imprinting Applications in Forensic Science

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