Use of FT-IR Internal Reflection Spectroscopy in Combinatorial Chemistry

Gremlich, Hans‐Ulrich; Berets, S. L.

doi:10.1366/0003702963906113

Cited by 40 publications

(17 citation statements)

References 5 publications

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“…During the conversion of 1 to 2 and subsequently 3, ATR-FT-IR [22,23] can monitor this transformation as the strong isocyanate resonance (~2254 cm À1 ) disappears and a new urea carbonyl appears (~1638 cm À1 ), see Figure 1. The transformation of the urea 2 to carbodiimide 3 was assessed by the appearance of a very strong IR peak at~2120 cm À1 and the corresponding disappearance of the urea carbonyl peak.…”

Section: Resultsmentioning

confidence: 99%

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A Convenient Solid Phase Synthesis of Disubstituted Guanidines

Sandanayake¹,

Perera²,

Ede³

2004

QSAR Comb. Sci.

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Full Paper TMI-isocyanate SynPhaseTM lanterns have been used in the convenient synthesis of a disubstituted guanidine library. Support-bound isocyanate was reacted with primary amines and the resulting urea derivatives were dehydrated to yield the corresponding support-bound carbodiimides. The carbodiimides were reacted with primary, secondary or anilinic amines to form the corresponding guanidines. Convenient traceless cleavage of the products from the solid phase with 25% TFA/DCM gave the corresponding guanidines in good yield and good to excellent purity.

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Section: Resultsmentioning

confidence: 99%

“…. FTIR spectra of lantern-bound 1 (isocyanate), 2 (urea) and 3 (carbodiimide) using the Perkin Elmer System 2000 FT-IR Spectrophotometer connected with the SPA (split-pea accessory) [22,23]. …”

Section: Resultsmentioning

confidence: 99%

A Convenient Solid Phase Synthesis of Disubstituted Guanidines

Sandanayake¹,

Perera²,

Ede³

2004

QSAR Comb. Sci.

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“…ATR spectra of the lantern surface were obtained by using a split‐pea accessory8 attached to a Perkin–Elmer 2000 series instrument. A total of 16 scans with a spectral resolution of 16 cm −1 were accumulated.…”

Section: Methodsmentioning

confidence: 99%

A combinatorial approach in designing hydrophilic surfaces for solid‐phase peptide synthesis

Ercole¹,

Fitzgerald²,

Perera³

et al. 2003

J of Applied Polymer Sci

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ABSTRACT:A hydrophilic surface suitable for solid-state peptide synthesis was developed on a solid support called a lantern. The split-and-mix combinatorial technique was used to prepare about 500 surfaces in a very short time. Surfaces were analyzed according to values for gel formation, percentage weight grafted, grafted copolymer composition, and number of functional groups per lantern. These values were correlated to the purity of a peptide synthesized on these surfaces.

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“…Fourier transformed-infra red spectroscopy (FT-IR): the PS surface (crown) was placed on the internal reflexion element (IRE) under a pressure of 1-2 lbs and the spectrum was obtained in the range 4000 -400 cm − 1 with 16 scans at a resolution of 4 cm − 1 on a Perkin-Elmer System 2000 FT-IR spectrophotometer connected to the SPA (SplitPea accessory) [9].…”

Section: Methodsmentioning

confidence: 99%

Acetophenone-based linker for solid-phase peptide synthesis

Bui¹,

Bray²,

Nguyen³

et al. 2000

J. Peptide Sci.

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A new and cost-effective linker for the generation of carboxylic acid end groups on Multipin supports (SynPhase crowns) has been developed. Synthesis of the linker was based on modification of grafted polystyrene (PS) crowns to generate a hydroxyethyl moiety which is acid labile in 10-20% trifluoroacetic acid (TFA) in dichloromethane (DCM). Solid-phase syntheses of model decapeptides using this linker are described.

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Use of FT-IR Internal Reflection Spectroscopy in Combinatorial Chemistry

Cited by 40 publications

References 5 publications

A Convenient Solid Phase Synthesis of Disubstituted Guanidines

A Convenient Solid Phase Synthesis of Disubstituted Guanidines

A combinatorial approach in designing hydrophilic surfaces for solid‐phase peptide synthesis

Acetophenone-based linker for solid-phase peptide synthesis

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