Use of galvanostatic coulometry for determining nitroxoline

Shlyamina, Oksana V.; Ziyatdinova, Guzel; Абдуллина, С. Г.; Будников, Г. К.

doi:10.1134/s1061934807100103

Cited by 6 publications

(3 citation statements)

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“…the typical plasma concentrations reported in literature for healthy volunteers following administration of a single oral dose of 100 mg nitroxoline were in the range (0.08 to 5.00 mg mL À1 ¼ 4.21 Â 10 À7 to 2.63 Â 10 À5 M), 6,10 the other reported methods 5,[7][8][9] are considered not efficient enough for the assay of nitroxoline at different therapeutic dose levels for pharmacokinetic studies as well as therapeutic drug monitoring.…”

Section: Introductionmentioning

confidence: 92%

“…3,4 As far as we know no official method is reported in the literature to date for the determination of nitroxoline in bulk form or formulation. The determination of nitroxoline has been reported by thin layer chromatography, 5 high performance liquid chromatography (HPLC), 6,7 colorimetry, 8 galvanostatic coulometry 9 and voltammetry. 10 The reported chromatographic methods are complicated, expensive and require sample pretreatment and time-consuming extraction steps prior to the analysis.…”

Section: Introductionmentioning

confidence: 99%

“…Beside, the high operator skill and instrumentation cost of HPLC limits its use in routine analysis. Also, the colorimetric method 9 for determination of nitroxoline required its interaction with electrogenerated bromine during the analysis. Moreover, because of Scheme 1 Chemical structure of nitroxoline.…”

Section: Introductionmentioning

confidence: 99%

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Voltammetric analysis of nitroxoline in tablets and human serum using modified carbon paste electrodes incorporating mesoporous carbon or multiwalled carbon nanotubes

et al. 2015

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Mesoporous carbon (MC) was synthesized using a mesoporous SiO 2 template material (SBA-15) and sucrose as the carbon source. SBA-15, MC as well as commercially obtained multi-walled carbon nanotubes (MWCNTs) were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), N 2 sorption isotherms and electrochemical impedance spectra. A carbon paste (CP) electrode modified with either MC or MWCNTs was used as a sensor for sensitive and selective determination of the nitroxoline drug. Using cyclic voltammetry, linear sweep and square-wave adsorptive stripping voltammetry, nitroxoline was found to oxidize via one developed peak at MWCNT/ CP and MC/CP electrodes compared to unmodified one. This is attributed to the stronger adsorptive character, lower charge transfer resistances and higher electrocatalytic activities of modified CP electrodes than the unmodified CP electrode. A well-defined peak and high current response were observed in a B-R universal buffer (pH 2.5) following preconcentration of nitroxoline by adsorption accumulation at À0.2 V (vs. Ag/AgCl/KCl s ). Limits of detection of 3.0 Â 10 À11 , 1.5 Â 10 À11 and 3.0 Â 10 À12 M nitroxoline, were obtained using the unmodified CP, MWCNT/CP and MC/CP electrodes, respectively. The utility of these sensors was examined for the determination of nitroxoline in its pharmaceutical dosage form (Nibiol® tablets) and human serum.

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