Use of Gas Sensors and FOBT for the Early Detection of Colorectal Cancer

Zonta, Giulia; Anania, Gabriele; Togni, Aldo De; Gaiardo, Andrea; Gherardi, S.; Giberti, A; Guidi, V.; Landini, Nicolò; Palmonari, Caterina; Ricci, Lorenzo; Malagù, C.

doi:10.3390/proceedings1040398

Cited by 7 publications

(7 citation statements)

References 8 publications

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“…Comparable results were reported using SIFT-MS, which differentiated patients affected by CRC and advanced adenoma from healthy controls with an accuracy of 75% (72% sensitivity and 78% specificity) [47]. More recently, the eNose Scent A1 performed even better in a relatively large cohort of patients (86 CRC and 71 controls) (Table 3) [48].…”

Section: Fecal Vocsmentioning

confidence: 73%

Are Volatile Organic Compounds Accurate Markers in the Assessment of Colorectal Cancer and Inflammatory Bowel Diseases? A Review

Vernia

Valvano

Fabiani

et al. 2021

Cancers

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Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the Western world. Early detection decreases incidence and mortality. Screening programs based on fecal occult blood testing help identify patients requiring endoscopic examination, but accuracy is far from optimal. Among the alternative strategies, volatile organic compounds (VOCs) represent novel potentially useful biomarkers of colorectal cancer. They also represent a promising tool for the screening of both intestinal inflammation and related CRC. The review is focused on the diagnostic potential of VOCs in sporadic CRC and in inflammatory bowel diseases (IBD), which increase the risk of CRC, analyzing future clinical applications. Despite limitations related to inadequate strength of evidence, differing analytical platforms identify different VOCs, and this unconventional approach for diagnosing colorectal cancer is promising. Some VOC profiles, besides identifying inflammation, seem disease-specific in inflammatory bowel diseases. Thus, breath, urine, and fecal VOCs provide a new and promising clinical approach to differential diagnosis, evaluation of the inflammatory status, and possibly the assessment of treatment efficacy in IBD. Conversely, specific VOC patterns correlating inflammatory bowel disease and cancer risk are still lacking, and studies focused on this issue are strongly encouraged. No prospective studies have assessed the risk of CRC development by using VOCs in samples collected before the onset of disease, both in the general population and in patients with IBD.

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Section: Fecal Vocsmentioning

confidence: 73%

Are Volatile Organic Compounds Accurate Markers in the Assessment of Colorectal Cancer and Inflammatory Bowel Diseases? A Review

Vernia

Valvano

Fabiani

et al. 2021

Cancers

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“…For this reason, a screening method based on the detection of tumor biomarkers, not directly related to occult blood (e.g., VOCs), can be useful to discriminate between CRC false and true positives resulting from FIT. A preliminary study, used to finalize the device, the best sensor array (shown in Table 2), and the analysis protocol, has been performed (in collaboration with the Department of Radiology and Section of General and Thoracic Surgery of the S. Anna Hospital of Ferrara) on fecal samples from CRC-affected patients (extracted during surgery) and from healthy volunteers [134]. As an example, the chosen sensors were successfully able to discriminate the health status of the subjects according to the Principal Component Analysis (PCA; Figure 19).…”

Section: Tumor Screeningmentioning

confidence: 99%

Overview of Gas Sensors Focusing on Chemoresistive Ones for Cancer Detection

Zonta,

Rispoli,

Malagù

et al. 2023

Chemosensors

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The necessity of detecting and recognizing gases is crucial in many research and application fields, boosting, in the last years, their continuously evolving technology. The basic detection principle of gas sensors relies on the conversion of gas concentration changes into a readable signal that can be analyzed to calibrate sensors to detect specific gases or mixtures. The large variety of gas sensor types is here examined in detail, along with an accurate description of their fundamental characteristics and functioning principles, classified based on their working mechanisms (electrochemical, resonant, optical, chemoresistive, capacitive, and catalytic). This review is particularly focused on chemoresistive sensors, whose electrical resistance changes because of chemical reactions between the gas and the sensor surface, and, in particular, we focus on the ones developed by us and their applications in the medical field as an example of the technological transfer of this technology to medicine. Nowadays, chemoresistive sensors are, in fact, strong candidates for the implementation of devices for the screening and monitoring of tumors (the second worldwide cause of death, with ~9 million deaths) and other pathologies, with promising future perspectives that are briefly discussed as well.

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“…On one hand, Gas chromatography-mass spectrometry (GC-MS), which is a chemical analytical technique, is considered the ongoing gold standard in VOC detection [52], but on the other hand, VOC sensors are getting more and more relevance because they are inexpensive, often portable, and easy to use [109]. This is why findings such as the ones listed in Table S7 (Supplementary material) could represent the next frontier for large population-based screening programs [50][51][52][53][54][55][56][57][58].…”

Section: Volatile Organic Compounds (Vocs) 271 Stool Vocsmentioning

confidence: 99%

“…Among them, SCENTA1 ® [58], that works using a pattern-recognition technology and was recently patented by Zonta et al [57], showed remarkable sensitivity and specificity (95%). The authors suggest that the addition of a technology that relies on a gaseous marker, totally different from occult blood, as a complementary test could drastically reduce false positive rates.…”

Section: Volatile Organic Compounds (Vocs) 271 Stool Vocsmentioning

confidence: 99%

“…The following are available online at https://www.mdpi.com/article/10.3 390/cancers13081820/s1, Table S1: Efficacy of SEPT9 methylation assays based tests for CRC detection, Table S2: Summary of methylated genes panels feasible for CRC detection, Table S3: miRNAs as CRC biomarkers, Table S4: piRNAs as CRC biomarkers, Table S5: t-M2-PK as CRC screening tool, Table S6: Gut microbiota as CRC screening tool, Table S7: Stool volatile organic compounds (VOCs) based CRC test: chemical analytical and pattern recognition techniques. References [16,17,[19][20][21][22][23][27][28][29][30][31][32][33][34][35][43][44][45][46][47][48][49][50][52][53][54][55][56][57] are cited in the Supplementary Materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

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Towards Novel Non-Invasive Colorectal Cancer Screening Methods: A Comprehensive Review

Ferrari¹,

Neefs²,

Hoeck³

et al. 2021

Preprint

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Colorectal cancer (CRC) is one of the leading cancer-related causes of death in the world. Since the 70s, many countries have adopted different CRC screening programs which has resulted in a decrease in mortality. However, current screening test options still present downsides. The commercialized stool-based tests present high false-positive rates and low sensitivity, which negatively affects the detection of early stage carcinogenesis. The gold standard colonoscopy has low uptake due to its invasiveness and the perception of discomfort and embarrassment that the procedure may bring.In this review, we collected and described the latest data about alternative CRC screening techniques that can overcome these disadvantages. Web of Science and PubMed were employed as search engines for studies reporting on CRC screening tests and future perspectives. The searches generated 555 articles, of which 93 titles were selected. Finally, a total of 50 studies, describing 14 different CRC alternative tests, were included. Among the investigated techniques the main feature that could have an impact on CRC screening perception and uptake was the ease of sample collection. Urine, exhaled breath and blood-based tests promise to achieve good diagnostic performance (sensitivity of 63-100%, 90-95%, 47-97%, respectively) while minimizing stress and discomfort for the patient.

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Use of Gas Sensors and FOBT for the Early Detection of Colorectal Cancer

Cited by 7 publications

References 8 publications

Are Volatile Organic Compounds Accurate Markers in the Assessment of Colorectal Cancer and Inflammatory Bowel Diseases? A Review

Are Volatile Organic Compounds Accurate Markers in the Assessment of Colorectal Cancer and Inflammatory Bowel Diseases? A Review

Overview of Gas Sensors Focusing on Chemoresistive Ones for Cancer Detection

Towards Novel Non-Invasive Colorectal Cancer Screening Methods: A Comprehensive Review

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