Use of Generalized Weighted Quantile Sum Regressions of Tumor Necrosis Factor Alpha and Kidney Function to Explore Joint Effects of Multiple Metals in Blood

Luo, Kuei-Hau; Tu, Hung-Pin; Yang, Chih‐Jen; Yang, Chen-Cheng; Chen, Tzu-Hua; Chuang, Hung‐Yi

doi:10.3390/ijerph19127399

Cited by 7 publications

(3 citation statements)

References 59 publications

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“…TNF-α can activate three diverse pathways: mitogen-activated protein kinase (MAPK), NF-κB, and cell death signaling pathways. The current results agree with the previously reported results [ 46 ]. In this study, RJ and P diminished the inflammatory markers’ elevation, mainly due to their phenolic mixes and other minor constituents [ 47 , 48 ].…”

Section: Discussionsupporting

confidence: 94%

Reversal Effects of Royal Jelly and Propolis Against Cadmium-Induced Hepatorenal Toxicity in Rats

Omar

El-Sayed

Elnozahy

et al. 2023

Biol Trace Elem Res

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Heavy metal toxicity is an exponentially growing health problem. In this study, we aimed to assess the protective properties of propolis and royal jelly against cadmium adverse effects. Thirty-two adult male rats were included in our study; kidney and liver functions, histopathological changes, and the level of oxidative stress were evaluated in rats exposed to a daily dose of 4.5 mg cadmium per kilogram of body weight for 1 month and those cotreated simultaneously with either propolis (50 mg/kg/day) or royal jelly (200 mg/kg/day) with cadmium compared to control animals. Cadmium-mediated hepatorenal toxicity was manifested as per the increased oxidative stress, function deterioration, and characteristic histopathological aberrations. The supplementation of royal jelly or propolis restores most of the affected parameters to a level similar to the control group. However, the parameters describing the grade of DNA damage and the interleukin-1β expression in the liver, as well as the levels of malondialdehyde and metallothionein, were slightly elevated compared to controls, despite the regular use of royal jelly or propolis. It is worth noting that better results were found in the case of royal jelly compared to propolis administration. Most likely, the ability of both products to chelate cadmium and contribute in reducing oxidative stress is of great importance. However, further investigations are needed to complement the knowledge about the expected nutritional and medicinal values. Graphical abstract

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Section: Discussionsupporting

confidence: 94%

Reversal Effects of Royal Jelly and Propolis Against Cadmium-Induced Hepatorenal Toxicity in Rats

Omar

El-Sayed

Elnozahy

et al. 2023

Biol Trace Elem Res

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“…These metals are associated with adverse health effects, including sarcopenia, osteoporosis, kidney damage, etc. 5 – 7 . Previous studies have reported that exposure to As, Cd, cobalt (Co), Pb, and mercury (Hg) could cause chronic diseases such as diabetes and obesity 8 – 10 .…”

Section: Introductionmentioning

confidence: 99%

The mediation effect of Systemic Immunity Inflammation Index between urinary metals and TOFAT among adults in the NHANES dataset

Zhang,

et al. 2024

Sci Rep

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Systemic Immune Inflammatory Index (SII) is a novel indicator of inflammation. However, no studies have reported the effect of SII on the association between metals and total fat (TOFAT). We aim to investigate the mediated effect of SII on the relationship between urinary metals and TOFAT in a US adult population. This cross-sectional study was conducted among adults with complete information on SII, urine metal concentrations, and TOFAT from the 2011–2018 National Health and Nutrition Examination Survey (NHANES). Multifactorial logistic regression and restricted cubic splines were used to explore the association between urine metal levels and TOFAT. Furthermore, serial mediation analyses were used to investigate the mediating effect of SII on metals and TOFAT. A total of 3324 subjects were included in this study. After adjusting for confounders, arsenic (As), cadmium (Cd), cobalt (Co), cesium (Cs), inorganic mercury (Hg), molybdenum (Mo), manganese (Mn), lead (Pb), antimony (Sb), and thallium(Tl) had negative decreased trends of odds ratios for TOFAT (all P for trend < 0.05). In the total population, we found that Cd, Co, and Tu were positively associated with SII (β = 29.70, 79.37, and 31.08), whereas As and Hg had a negative association with SII. The mediation analysis showed that SII mediated the association of Co with TOFAT, with the β of the mediating effect being 0.9% (95%CI: 0.3%, 1.6%). Our findings suggested that exposure to As, Cd, and Hg would directly decrease the level of TOFAT. However, Co would increase TOFAT, completely mediated by SII, mainly exerted in females rather than males.

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“…Metals are associated with adverse health effects, sarcopenia, osteoporosis, kidney damage, etc [5][6][7]. Previous studies have reported that exposure to As, Cd, cobalt (Co), Pb, and mercury (Hg) could cause chronic diseases such as diabetes and obesity [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The mediation effect of Systemic Immunity Inflammation Index between urinary metals and TOFAT among adults in the NHANES dataset

Nie,

Lu,

Zhang

et al. 2023

Preprint

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Background: Systemic Immune Inflammatory Index (SII) is a novel indicator of inflammation. However, no studies have reported the effect of SII on the association between metals and total fat (TOFAT). We aim to investigate the mediated effect of SII on the relationship between urinary metals and TOFAT in a US adult population. Methods: This cross-sectional study was conducted among adults with complete information on SII, urine metal concentrations, and TOFAT from the 2011-2018 National Health and Nutrition Examination Survey (NHANES). Multifactorial logistic regression and restricted cubic splines were used to explore the association between urine metal levels and TOFAT. Furthermore, serial mediation analyses were used to investigate the mediating effect of SII on metals and TOFAT. Results: A total of 3324 subjects were included in this study. After adjusting for covariates, arsenic (As), cadmium (Cd), cobalt (Co), cesium (Cs), inorganic mercury (Hg), molybdenum (Mo), manganese (Mn), lead (Pb), and antimony (Sb) had negative and significant decreased trends of odds ratios for TOFAT (all P for trend < 0.05). In the total population, we found that Cd, Co, and Tu had a significant positive association with SII [β = 34.67 (95%CI: 1.65, 67.70); β = 54.49 (95%CI: 12.20, 96.78); β = 29.46 (95%CI: 1.67, 57.24)], whereas As and Hg had a negative association with SII. The results of mediation analysis showed that SII had significant mediated effects on the associations of Co with TOFAT, and the beta coefficient of mediating effect was 0.8% (95%CI: 0.2, 0.5%; P= 0.020). The mediating effects of SII were not statistically significant on the associations of As, Cd, and Hg with TOFAT (all P > 0.05). Conclusions: Our findings suggested that exposure to As, Cd, and Hg would directly decrease the level of TOFAT. However, Co would increase TOFAT, completely mediated by SII, which was mainly exerted in females rather than males.

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Use of Generalized Weighted Quantile Sum Regressions of Tumor Necrosis Factor Alpha and Kidney Function to Explore Joint Effects of Multiple Metals in Blood

Cited by 7 publications

References 59 publications

Reversal Effects of Royal Jelly and Propolis Against Cadmium-Induced Hepatorenal Toxicity in Rats

Reversal Effects of Royal Jelly and Propolis Against Cadmium-Induced Hepatorenal Toxicity in Rats

The mediation effect of Systemic Immunity Inflammation Index between urinary metals and TOFAT among adults in the NHANES dataset

The mediation effect of Systemic Immunity Inflammation Index between urinary metals and TOFAT among adults in the NHANES dataset

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