Use of ginsenoside Rg3-loaded electrospun PLGA fibrous membranes as wound cover induces healing and inhibits hypertrophic scar formation of the skin

Sun, Xiaoming; Cheng, Liying; Zhu, Wankun; Hu, Changmin; Jin, Rong; Sun, Baoshan; Shi, Yongjun; Zhang, Yuguang; Cui, Wenguo

doi:10.1016/j.colsurfb.2013.11.030

Cited by 63 publications

(32 citation statements)

References 39 publications

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“…In this regard, the development of several wound healing dressings such as curcumin-loaded PLA nanofibers [82], PGA/collagen composite nanofibrous scaffolds [83], nanofibrous scaffolds containing gum tragacanth/PCL [84] and poly(lactide-co-glycolic acid) (PLGA)/silk fibroin hybrid scaffolds [85] have demonstrated a great potential as wound healing materials. Sun et al [86] showed that the use of ginsenoside Rg3-loaded electrospun PLGA fibrous membranes as wound covers induces healing and inhibits hypertrophic scar formation.…”

Section: Methodsmentioning

confidence: 99%

Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

et al. 2015

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A fast and effective wound healing process would substantially decrease medical costs, wound care supplies, and hospitalization significantly improving the patients’ quality of life. The search for effective therapeutic approaches seems to be imperative in order to avoid the aggravation of chronic wounds. In spite of all the efforts that have been made during the recent years towards the development of artificial wound dressings, none of the currently available options combine all the requirements necessary for quick and optimal cutaneous regeneration. Therefore, technological advances in the area of temporary and permanent smart dressings for wound care are required. The development of nanoscience and nanotechnology can improve the materials and designs used in topical wound care in order to efficiently release antimicrobial, anti-inflammatory and regenerative compounds speeding up the endogenous healing process. Nanostructured dressings can overcome the limitations of the current coverings and, separately, natural origin components can also overcome the drawbacks of current antibiotics and antiseptics (mainly cytotoxicity, antibiotic resistance, and allergies). The combination of natural origin components with demonstrated antibiotic, regenerative, or anti-inflammatory properties together with nanostructured materials is a promising approach to fulfil all the requirements needed for the next generation of bioactive wound dressings. Microbially compromised wounds have been treated with different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring antimicrobial, anti-inflammatory, and regenerative components but the available evidence is limited and insufficient to be able to draw reliable conclusions and to extrapolate those findings to the clinical practice. The evidence and some promising preliminary results indicate that future comparative studies are justified but instead of talking about the beneficial or inert effects of those natural origin occurring materials, the scientific community leads towards the identification of the main active components involved and their mechanism of action during the corresponding healing, antimicrobial, or regenerative processes and in carrying out systematic and comparative controlled tests. Once those natural origin components have been identified and their efficacy validated through solid clinical trials, their combination within nanostructured dressings can open up new avenues in the fabrication of bioactive dressings with outstanding characteristics for wound care. The motivation of this work is to analyze the state of the art in the use of different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring materials as antimicrobial, anti-inflammatory and regenerative components with the aim of clarifying their potential clinical use in bioactive dressings. We conclude that, for those natural occurring materials, more clinical trials are needed to reach a sufficient level ...

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Section: Methodsmentioning

confidence: 99%

Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

et al. 2015

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“…and CD8(?) T cells [64] Hair loss prevention Induction of p63 expression [44] Wound healing Increase of intracellular cAMP levels and phosphorylated CEBP expression in nucleus [36] Rg3 Antitumor Reduce TPA-induced activation of NF-jB and ERK Down-regulation of NF-jB and AP-1 transcription factors [8,28,61] Anti-scar formation Decrease of VEGF and collage Type I [12,60] Compound K Antiwrinkle formation Up-regulate production of type I collagen [17] Photoprotection Increase the expression of NER complex, such as XPC and ERCC1 [6] Skin hydration Induce HAS1 upregulation and HA production [34] Anti-atopic dermatitis Reduce MDC level in serum, eosinophils' infiltration and mast cells in skin, and cytokine production in splenocytes [31] Arch Dermatol Res that ginsenoside Rg3 not only inhibits HCC tumor growth and pathology in an animal model, but also improves overall survival [22]. Mitochondrial-mediated apoptosis pathways have also been suggested as another mechanism of action for ginsenoside Rg3 [52], which increases cellular reactive oxygen species (ROS) production and subsequent accumulation of cytochrome C in the cytosol.…”

Section: Biological Activitiesmentioning

confidence: 99%

Ginsenosides and their metabolites: a review of their pharmacological activities in the skin

et al. 2015

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Ginsenosides are representative pharmaceutical compounds found in various forms in Panax ginseng, a traditional medicinal plant. They are converted to their metabolites Rg2, Rg3, compound K, and others by human intestinal microflora following ingestion. Numerous studies have demonstrated beneficial effects of ginsenosides against aberrant molecular processes responsible for cancer, metabolic diseases and neurodegenerative diseases. Recently, antiaging effects of ginsenosides in human skin have been reported from clinical trial and in vitro model data. Ginsenosides have hence been proposed as promising natural cosmeceutical agents. In this review, we will critically review the known biological effects of several ginsenosides (Rb1, Rg3, Rd and compound K), such as anti-inflammatory and anticancer activities, which arise from the modulation of diverse molecular pathways. The application potential of ginsenosides as cosmeceutical ingredients will also be reviewed.

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“…Some in vitro biomaterial membranes studies specialized in scar prevention application such as ginsenoside Rg3-loaded electrospun poly(lactic-co-glycolic acid) (PLGA) fibrous membranes as cutaneous wound cover [49]. As a result of using the biomembranes, the expression of vascular endothelial growth factor (VEGF), mRNA and Collagen Type I was found to decrease significantly, and consequently, to cause shorter healing time and to inhibit hypertrophic scar formation [49]. …”

Section: Introductionmentioning

confidence: 99%

Biomaterials and tissue engineering for scar management in wound care

2017

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Scars are a natural and unavoidable result from most wound repair procedures and the body’s physiological healing response. However, they scars can cause considerable functional impairment and emotional and social distress. There are different forms of treatments that have been adopted to manage or eliminate scar formation. This review covers the latest research in the past decade on using either natural agents or synthetic biomaterials in treatments for scar reduction.

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Use of ginsenoside Rg3-loaded electrospun PLGA fibrous membranes as wound cover induces healing and inhibits hypertrophic scar formation of the skin

Cited by 63 publications

References 39 publications

Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

Ginsenosides and their metabolites: a review of their pharmacological activities in the skin

Biomaterials and tissue engineering for scar management in wound care

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