Use of Glutaric Acid to Improve the Solubility and Dissolution Profile of Glipizide Through Pharmaceutical Cocrystallization

Batool, Fakhra; Ahmad, Mahmood; Minhas, Muhammad Usman; Khalid, Qandeel; Idrees, Hafiz Arfat; Khan, Fahad M.

doi:10.32383/appdr/94246

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…The solution is then allowed to evaporate slowly for 48 h at room temperature. The resulting solid crystal is filtered, washed, dried, sieved, and stored for further evaluation [63].…”

Section: Slurry Conversionmentioning

confidence: 99%

A Review of Coformer Utilization in Multicomponent Crystal Formation

et al. 2022

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Most recently discovered active pharmaceutical molecules and market-approved medicines are poorly soluble in water, resulting in limited drug bioavailability and therapeutic effectiveness. The application of coformers in a multicomponent crystal method is one possible strategy to modulate a drug’s solubility. A multicomponent crystal is a solid phase formed when several molecules of different substances crystallize in a crystal lattice with a certain stoichiometric ratio. The goal of this review paper is to comprehensively describe the application of coformers in the formation of multicomponent crystals as solutions for pharmaceutically active ingredients with limited solubility. Owing to their benefits including improved physicochemical profile of pharmaceutically active ingredients, multicomponent crystal methods are predicted to become increasingly prevalent in the development of active drug ingredients in the future

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“…The solution is then allowed to evaporate slowly for 48 h at room temperature. The resulting solid crystal is filtered, washed, dried, sieved, and stored for further evaluation [63].…”

Section: Slurry Conversionmentioning

confidence: 99%

A Review of Coformer Utilization in Multicomponent Crystal Formation

et al. 2022

View full text Add to dashboard Cite

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Mechanochemistry: A Green Approach in the Preparation of Pharmaceutical Cocrystals

et al. 2021

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Mechanochemistry is considered an alternative attractive greener approach to prepare diverse molecular compounds and has become an important synthetic tool in different fields (e.g., physics, chemistry, and material science) since is considered an ecofriendly procedure that can be carried out under solvent free conditions or in the presence of minimal quantities of solvent (catalytic amounts). Being able to substitute, in many cases, classical solution reactions often requiring significant amounts of solvents. These sustainable methods have had an enormous impact on a great variety of chemistry fields, including catalysis, organic synthesis, metal complexes formation, preparation of multicomponent pharmaceutical solid forms, etc. In this sense, we are interested in highlighting the advantages of mechanochemical methods on the obtaining of pharmaceutical cocrystals. Hence, in this review, we describe and discuss the relevance of mechanochemical procedures in the formation of multicomponent solid forms focusing on pharmaceutical cocrystals. Additionally, at the end of this paper, we collect a chronological survey of the most representative scientific papers reporting the mechanochemical synthesis of cocrystals.

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Use of Glutaric Acid to Improve the Solubility and Dissolution Profile of Glipizide Through Pharmaceutical Cocrystallization

Cited by 2 publications

References 22 publications

A Review of Coformer Utilization in Multicomponent Crystal Formation

A Review of Coformer Utilization in Multicomponent Crystal Formation

Mechanochemistry: A Green Approach in the Preparation of Pharmaceutical Cocrystals

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