Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus

Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles

“…23 Already many researchers have reported that the leaves of G. sylvestre lower blood sugar, stimulate the heart, uterus, and circulatory systems, and exhibit anti-sweet and hepatoprotective activities. 20,[24][25][26][27][28][29][30][31] Administration of G. sylvestre extract to diabetic rats increased superoxide dismutase activity and decreased lipid peroxide by either directly scavenging the reactive oxygen species, due to the presence of various antioxidant compounds, or by increasing the synthesis of antioxidant molecules (albumin and uric acid). 24,30,32 …”

Aldose reductase inhibitory activity and anti catraract potential of some traditionally acclaimed antidiabetic medicinal plants

“…In the present study, aqueous extracts of four reputed antidiabetic plants viz. Enicostemma hyssopifolium (Vijayvargia et al, 2000;Vasu et al, 2002;Srinivasan et al, 2005), Gymnema sylvestre Shanmugasundaram et al, 1990), Eclipta alba (Ananthi et al, 2003), and Tinospora cordifolia (Wadood et al, 1992;Stanely et al, 2000) were selected to evaluate their AR inhibiting potential and anticataract activity in vitro. The selection criteria of aqueous extracts of plants relied on their reported hypoglycemic activity and their usage as common ingredient of many antidiabetic polyherbal formulations.…”

Comparative Proximate Composition and Hypoglycemic Properties of Three Medicinal Plants (Verononia amygdalina, Azadirachta indica and Moringa oleifera).

“…Such mechanisms include promoting biosynthesis of enzymes and structural molecules required for regeneration and restoration of the functional integrity of insulin secreting cells (Islet of Langerhans) in concert with quick acting mechanism of insulin mimicking. [40,[69][70] The leaves of Gymnema sylvestre (Gumer) [71] and the fruits of T. catappa Linn [50] induced β-cell regeneration in simultaneous with β-cell stimulation and suppression of gluconeogenic enzymes [72] that corroborates the plausible mode of action of V. amygdalina, A. indica and M. oleifera extracts. From another perspective, Ugochukwu and Babady, [73] reported that the long-term hypoglycemic property of Gongronema latifolium extract was mediated by activation of hepatic hexokinase, phosphofructokinase, glucose-6-phosphate dehydrogenase in diabetic rats.…”