Related to a semigroup of operators on a metric measure space, we define and study pseudodifferential operators (including the setting of Riemannian manifold, fractals, graphs ...). Boundedness on L p for pseudodifferential operators of order 0 are proved. Mainly, we focus on symbols belonging to the class S 0 1,δ for δ ∈ [0, 1). For the limit class S 0 1,1 , we describe some results by restricting our attention to the case of a sub-Laplacian operator on a Riemannian manifold.