Organic Rankine Cycle (ORC) thermodynamic optimization is of critical importance while developing new plants. Optimization procedures may be imed at the highest efficiency as well as cost or sizing minimization. Optimization process is generally carried out for plant nominal rating. At the same time, part-load operation has to be carefully considered in case of waste heat recovery from flue gases coming from internal combustion engines or gas turbines. Gas mass flow and temperature variations are specific to this application, significantly influencing ORC plant performance. Secure prediction of part-load operation is of particular importance for assessment of plant power output, providing stability and safety and utilizing proper control strategy. In this paper design and off-design cycle simulation model is proposed. Off-design performance of the ORC cycle recovering waste heat from gas turbine unit installed at gas compressor station is considered. Major factors affecting system performance are outlined.