Use of Hierarchical Carbon Nanofibers Decorated with NiCo Nanoparticles for Highly Sensitive Vortioxetine Determination

Abstract

A new voltammetry method for the highly sensitive antidepressant drug vortioxetine (VOR) is presented using glassy carbon electrodes modified with hierarchical carbon nanofibers with NiCo nanoparticles (eCNF/CNT/NiCo-GCE). The electrochemical behavior of VOR was investigated by cyclic voltammetry, which indicates that its oxidation is an adsorption-controlled process with the exchange of two electrons and one proton. The effects of various factors on the VOR peak, such as supporting electrolyte type, preconcentration time, and potential, or influence of interferents, were tested using the square wave voltammetry technique (SWV). The linear voltametric response for the analyte was obtained in the concentration range from 0.01·10−6 to 3.0·10−6 mol L−1 with the detection limit of 1.55·10−9 mol L−1 for a preconcentration time of 60 s. The proposed method was successfully applied for highly sensitive VOR determination in complex matrices such as tablets, urine, and plasma with good recovery parameter.

Analytical eco-scale determination of vortioxetine using advanced electrochemical platform for screen-printed disposable multiwalled carbon nanotube electrode in the presence of an anionic surfactant

“…The literature survey showed few methods utilizing different techniques for the analysis of VOR, including HPLC, [5][6][7] TLC, 8 spectrophotometry, 9 and voltammetry. [10][11][12][13][14] The published stripping differential pulse voltammetry method used gold nanoparticles/graphene/(AuNPs@GRP) nanocomposite 10 and the other methods employed carbon nanotube-modified stencil-printed electrode, 11 three-dimensional nickel ferrite nanospheres, 12 glassy carbon electrodes modified with hierarchical carbon nanofibers with NiCo nanoparticles, 13 and graphite pencil electrode, 14 which were already used for VOR detection; however, these processes are costly and consume a lot of time. For electrodes, the preparation of the electrode is a very complicated and sophisticated process, which takes a lot of time and requires special precautions to ensure developing electrodes with same repeatability and reproducibility.…”

Carbon-Based Nanomaterials 4.0

“…Thus, voltametric methods may be an alternate method for VOR determination. In this regard, Smajdor et al [ 37 ] designed a new approach based on square-wave voltammetry to detect this analyte, using glassy carbon electrodes modified with electrospun carbon nanofibers and NiCo nanoparticles, and applied it in several samples including urine and plasma.…”