Use of high dose corticosteroids in patients with inoperable brain tumours.

Lieberman, Abraham; Lebrun, Yves; Glass, Parisa; Goodgold, Albert; Lux, Warren E.; Wise, Amanda L.; Ransohoff, Joseph

doi:10.1136/jnnp.40.7.678

Cited by 47 publications

(13 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, there is a recent report of patients with brain tumors who were not responding to conventional pharmacologic doses of steroids, but showed clinical improvement when massive doses were used. 25 In both our own studies and in the negative studies reported, 21 -22 conventional pharmacological doses of steroids were used. We have, therefore, repeated our studies on steroids in the rhesus monkey using massive doses.…”

Section: Stroke Vol 10 No 6 November-december 1979mentioning

confidence: 86%

Massive doses of steroids in cryogenic cerebral injury and edema.

Clasen¹,

Pandolfi²,

Clasen³

1979

Stroke

View full text Add to dashboard Cite

Section: Stroke Vol 10 No 6 November-december 1979mentioning

confidence: 86%

Massive doses of steroids in cryogenic cerebral injury and edema.

Clasen¹,

Pandolfi²,

Clasen³

1979

Stroke

View full text Add to dashboard Cite

“…1). Sensitivity to all agents i in only 2 untreated patients Resistance to all agents was seen reated patients (4, 5) and in one 14). In untreated patients without ;y to thiotepa, drugs which still -ytotoxicity were phosphoramide (3, 9), cis-platinum (6, 9, 13) and n (12).…”

Section: Alkylating Agentsmentioning

confidence: 99%

In vitro sensitivity of human ovarian tumours to chemotherapeutic agents

Wilson¹,

Neal²

1981

Br J Cancer

View full text Add to dashboard Cite

Summary.-The in vitro chemosensitivity of primary monolayer cultures of human ovarian tumours to a wide range of chemotherapeutic agents has been determined using 3H-leucine incorporation as an index of cytotoxicity. Of 67 specimens received, 35 have been successfully cultured and tested for chemosensitivity. Drugs tested included alkylating agents, antibiotics, antimitotics, antimetabolites and progestogens. The overall incidence of efficacy of the drugs corresponded with the incidence which might be expected from data on the clinical response rates produced by the various drugs. Cultures from the tumour cells of treated patients generally showed greater resistance than tumours of untreated patients. Correlation between in vitro results and in vivo response was positive in all 8 patients receiving first-line chemotherapy and in 57oo (4/7) patients receiving second-line chemotherapy.

show abstract

“…While glucocorticoids are used clinically to reduce intracranial pressure, alleviate head pain and reduce post-operative trauma [22], high dose glucocorticoids may also halt the progression ofhuman glioma [16]. Glucocor ticoids can modify the growth of normal and malignant human glial cells in vitro without exerting any cytotoxic effect [9,13] and have a traditional role in the induction of differen tiation [20].…”

mentioning

confidence: 99%

Effects of Glucocorticoids on Glioma Cells in Culture

Ri¹

1984

Pathobiology

View full text Add to dashboard Cite

In vitro studies have shown that glucocorticoids have a cytostatic effect on glioma cells at high cell densities but enhance cell survival and proliferation at low cell densities. The cytostatic effect is not cytotoxic and may be mediated via a membrane modification altering cell-cell interaction. Cell interaction is also implicated in differentiation in glial cells and the inducing effect of glucocorticoids may be mediated in part by their effect on cell interaction. Induction of differentiation by glucocorticoids is accompanied by a reduction in malignancy-associated properties and the possibility has emerged that glucocorticoids may be an essential component in attempts to modify the malignant behaviour of glioma cells.

show abstract

Use of high dose corticosteroids in patients with inoperable brain tumours.

Cited by 47 publications

References 20 publications

Massive doses of steroids in cryogenic cerebral injury and edema.

Massive doses of steroids in cryogenic cerebral injury and edema.

In vitro sensitivity of human ovarian tumours to chemotherapeutic agents

Effects of Glucocorticoids on Glioma Cells in Culture

Contact Info

Product

Resources

About