Use of host lipids by the Lyme disease spirochete may lead to biomarkers

Arora, Gunjan; Hart, Thomas; Fikrig, Erol

doi:10.1172/jci158254

Cited by 5 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By including host’s lipoproteins and lipids, such as phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylserine (PS) and cholesterol, the host immune system develops autoantibodies to those lipids. The detection of the elevation of antiphospholipid antibodies against PC, PG, or PS, but not against cardiolipin, may first aid in the diagnosis of Lyme disease, but also distinguished LB from syphilis and some other diseases [ 132 , 133 ]. Interestingly, Molins et almanaged, by analyzing a metabolomic signature, to differentiate early LB from southern tick − associated rash illness (STARI) with an accuracy of 85 to 98%.…”

Section: Indirect Diagnosismentioning

confidence: 99%

Lyme borreliosis diagnosis: state of the art of improvements and innovations

Guérin,

Shawky,

Zedan

et al. 2023

BMC Microbiol

View full text Add to dashboard Cite

With almost 700 000 estimated cases each year in the United States and Europe, Lyme borreliosis (LB), also called Lyme disease, is the most common tick-borne illness in the world. Transmitted by ticks of the genus Ixodes and caused by bacteria Borrelia burgdorferi sensu lato, LB occurs with various symptoms, such as erythema migrans, which is characteristic, whereas others involve blurred clinical features such as fatigue, headaches, arthralgia, and myalgia. The diagnosis of Lyme borreliosis, based on a standard two-tiered serology, is the subject of many debates and controversies, since it relies on an indirect approach which suffers from a low sensitivity depending on the stage of the disease. Above all, early detection of the disease raises some issues. Inappropriate diagnosis of Lyme borreliosis leads to therapeutic wandering, inducing potential chronic infection with a strong antibody response that fails to clear the infection. Early and proper detection of Lyme disease is essential to propose an adequate treatment to patients and avoid the persistence of the pathogen. This review presents the available tests, with an emphasis on the improvements of the current diagnosis, the innovative methods and ideas which, ultimately, will allow more precise detection of LB.

show abstract

Section: Indirect Diagnosismentioning

confidence: 99%

Lyme borreliosis diagnosis: state of the art of improvements and innovations

Guérin,

Shawky,

Zedan

et al. 2023

BMC Microbiol

View full text Add to dashboard Cite

show abstract

“…In human sera, the same pattern of IgG production against phospholipids has been described. In brief, these spirochetes are capable of incorporating host phospholipids, and this mechanism is probably related to the occurrence of symptoms related to autoimmunity, thus important to the pathogenesis of the disease (Arora et al, 2022;Gwynne et al, 2022).…”

Section: Lipids and Bacterial Infectionmentioning

confidence: 99%

“…The interaction of pathogens with surface receptors and lipid rafts is necessary for adhesion, but also facilitates entrance into the cell, in the case of intracellular pathogens (van der Meer-Janssen et al, 2010;Crowley et al, 2013;Vromman and Subtil, 2014;Du et al, 2016). The close contact between host cells and bacteria also facilitates the interchange of phospholipids, as in the case of B. burgdorferi and H. pylori (Wunder et al, 2006;Crowley et al, 2013;Du et al, 2016;Qaria et al, 2021;Arora et al, 2022;Gwynne et al, 2022).…”

Section: Lipids and Bacterial Infectionmentioning

confidence: 99%

Cell lipid biology in infections: an overview

Prado,

Camara,

Barbosa

2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Lipids are a big family of molecules with a vast number of functions in the cell membranes, within the cytoplasm, and extracellularly. Lipid droplets (LDs) are the most common storage organelles and are present in almost every tissue type in the body. They also have structural functions serving as building blocks of cellular membranes and may be precursors of other molecules such as hormones, and lipoproteins, and as messengers in signal transduction. Fatty acids (FAs), such as sterol esters and triacylglycerols, are stored in LDs and are used in β-oxidation as fuel for tricarboxylic acid cycle (TCA) and adenosine triphosphate (ATP) generation. FA uptake and entrance in the cytoplasm are mediated by membrane receptors. After a cytoplasmic round of α- and β-oxidation, FAs are guided into the mitochondrial matrix by the L-carnitine shuttle system, where they are fully metabolized, and enter the TCA cycle. Pathogen infections may lead to impaired lipid metabolism, usage of membrane phospholipids, and LD accumulation in the cytoplasm of infected cells. Otherwise, bacterial pathogens may use lipid metabolism as a carbon source, thus altering the reactions and leading to cellular and organelles malfunctioning. This review aims to describe cellular lipid metabolism and alterations that occur upon infections.

show abstract

“…Furthermore, antiphospholipid antibodies, such as anti-cardiolipin, have been utilized as a diagnostic tool for active Treponema pallidum infections, being one of the primary methods to diagnose syphilis in humans (71). A similar application was recently suggested for Lyme disease diagnosis (72). Anti-phospholipid and anti-ganglioside autoantibodies were also reported to be correlated in Zika virus-associated Guillain-Barrésyndrome patients from Brazil (73,74).…”

Section: Lessons From Malaria Applied To Covid-19 and Other Infectionsmentioning

confidence: 99%

Autoantibodies during infectious diseases: Lessons from malaria applied to COVID-19 and other infections

Rivera-Correa

Rodrı́guez

2022

Front. Immunol.

View full text Add to dashboard Cite

Autoimmunity is a common phenomenon reported in many globally relevant infections, including malaria and COVID-19. These and other highly inflammatory diseases have been associated with the presence of autoantibodies. The role that these autoantibodies play during infection has been an emerging topic of interest. The vast numbers of studies reporting a range of autoantibodies targeting cellular antigens, such as dsDNA and lipids, but also immune molecules, such as cytokines, during malaria, COVID-19 and other infections, underscore the importance that autoimmunity can play during infection. During both malaria and COVID-19, the presence of autoantibodies has been correlated with associated pathologies such as malarial anemia and severe COVID-19. Additionally, high levels of Atypical/Autoimmune B cells (ABCs and atypical B cells) have been observed in both diseases. The growing literature of autoimmune B cells, age-associated B cells and atypical B cells in Systemic Lupus erythematosus (SLE) and other autoimmune disorders has identified recent mechanistic and cellular targets that could explain the development of autoantibodies during infection. These new findings establish a link between immune responses during infection and autoimmune disorders, highlighting shared mechanistic insights. In this review, we focus on the recent evidence of autoantibody generation during malaria and other infectious diseases and their potential pathological role, exploring possible mechanisms that may explain the development of autoimmunity during infections.

show abstract

Use of host lipids by the Lyme disease spirochete may lead to biomarkers

Cited by 5 publications

References 24 publications

Lyme borreliosis diagnosis: state of the art of improvements and innovations

Lyme borreliosis diagnosis: state of the art of improvements and innovations

Cell lipid biology in infections: an overview

Autoantibodies during infectious diseases: Lessons from malaria applied to COVID-19 and other infections

Contact Info

Product

Resources

About