Use of human papillomavirus DNA testing to compare equivocal cervical cytologic interpretations in the United States, Scandinavia, and the United Kingdom

Scott, David; Hagmar, Björn; Maddox, P.; Hjerpe, Anders; Dillner, Joakim; Cuzick, Jack; Sherman, Mark E.; Stoler, Mark H.; Kurman, Robert J.; Kiviat, Nancy B.; Manos, M. Michele; Schiffman, Mark

doi:10.1002/cncr.10317

Cited by 45 publications

(26 citation statements)

References 31 publications

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“…Scandinavian cytologists tend to rate the samples as WNL more frequently than British or American cytologists (abnormal smear rate: 3 -5 vs 10 -15%), discounting subtle changes in deference to achieving cytological certainty (Scott et al, 2002). In spite of these differences, our results suggest that the value of HR-HPV detection in cases of minor cytological abnormalities is high also in a Swedish context.…”

Section: Discussioncontrasting

confidence: 55%

Human papillomavirus ‘reflex’ testing as a screening method in cases of minor cytological abnormalities

et al. 2008

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The aim was to evaluate human papillomavirus (HPV) 'reflex genotyping' in cases of minor cytological abnormalities detected in the gynaecological screening programme in Stockholm, Sweden. Liquid-based cytology samples showing minor cytological abnormalities were analysed using HPV genotyping (Linear Array, Roche diagnostics). Colposcopically directed cervical biopsies were obtained and the HPV test results were correlated with the histological results. In all, 63% (70/112) of the samples were high-risk (HR) HPV (HR-HPV) positive. A statistically significant correlation was found between high-grade cervical lesions and HR-HPV (P ¼ 0.019), among which HPV 16, 18, and 31 were the most important. The negative predictive value of HR-HPV detection for histologically confirmed high-grade lesions was 100%. An age limit for HPV reflex testing may be motivated in cases of low-grade squamous intraepithelial neoplasia (LSIL), because of high HR-HPV prevalence among younger women. By using HPV reflex genotyping, additional extensive workup can safely be avoided in about 50% of all cases of atypical squamous cells of undetermined significance (ASCUS) and LSIL among women X30 years. This screening strategy could potentially reduce the total abnormal cytology-reporting rate in the Swedish screening programme by about 1% and provide more accurately directed follow-up, guided by cytological appearance and HPV test results.

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Section: Discussioncontrasting

confidence: 55%

Human papillomavirus ‘reflex’ testing as a screening method in cases of minor cytological abnormalities

et al. 2008

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“…Thus, if the accuracy and the cost-effectiveness of HPV detection for triage of women with AFR is in the future documented, it may be proposed to keep the AFR category, and triage it by HPV testing, similarly to ASC-US. Additionally, taking into account the questionable utility of ASC qualification (Malik et al, 1999;Anton et al, 2001;Pitman et al, 2002) and the poor inter-observer reproducibility reported in AFR (Stoler and Schiffmann, 2001;Scott et al, 2002), the approach of not subcategorising the ASC diagnosis, but to consider it as a unique category, to be triaged as a whole by HPV testing, could be also taken into account.…”

Section: Discussionmentioning

confidence: 98%

Atypical squamous cells of undetermined significance-favour reactive compared to atypical squamous cells of undetermined significance-favour dysplasia: association with cervical intraepithelial lesions and human papillomavirus infection

Giovannelli

Capra

Lama

et al. 2005

Journal of Clinical Virology

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“…6 Finally, some prior studies may have considered some LSIL and atypical squamous cell cytology as negative. It is now apparent that there are significant regional/national differences in threshold of cytologic abnormality (28). HPV-positive cytology is more likely to be reclassified as SIL upon review than HPV-negative cytology, with an attendant higher risk of subsequent CIN3 and cancer.…”

Section: Discussionmentioning

confidence: 99%

Semiquantitative Human Papillomavirus Type 16 Viral Load and the Prospective Risk of Cervical Precancer and Cancer

Castle

Schiffman

Scott

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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We examined whether higher human papillomavirus type 16 (HPV16) viral load predicted risk of cervical intraepithelial neoplasia 3 (CIN3) or cancer (together termed z zCIN3) within a cohort of 20,810 women followed for 10 years with cytologic screening. Semiquantitative viral load for HPV16 was measured on baseline cervicovaginal specimens using a type-specific hybridization probe test with signal amplification. An increased risk of z zCIN3 associated with higher HPV16 viral load was found only among cytologically negative women in early follow-up, suggesting that these cases were related to the detection of prevalent lesions missed at baseline. Women with higher HPV16 viral load were more likely to undergo ablative treatment during follow-up than those with lower viral load (P trend = 0.008), possibly diminishing any additional risk for z zCIN3 attributable to higher HPV16 viral loads.

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Use of human papillomavirus DNA testing to compare equivocal cervical cytologic interpretations in the United States, Scandinavia, and the United Kingdom

Cited by 45 publications

References 31 publications

Human papillomavirus ‘reflex’ testing as a screening method in cases of minor cytological abnormalities

Human papillomavirus ‘reflex’ testing as a screening method in cases of minor cytological abnormalities

Atypical squamous cells of undetermined significance-favour reactive compared to atypical squamous cells of undetermined significance-favour dysplasia: association with cervical intraepithelial lesions and human papillomavirus infection

Semiquantitative Human Papillomavirus Type 16 Viral Load and the Prospective Risk of Cervical Precancer and Cancer

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