Use of Human VEGF165 Gene for Therapeutic Angiogenesis in Coronary Patients: First Results

Abstract

The paper presents the first results of therapeutic angiogenesis in clinical cardiosurgery: human VEGF(165) gene transplantation to coronary patients. The use of this therapeutic method is particularly effective in patients with inoperable cardiovascular injuries, i.e. patients with the most severe condition, in whom treatment remains little effective at the modern level of cardiosurgery development.

Terapia gênica com VEGF para angiogênese na angina refratária: ensaio clínico fase I/II

“…Other previous reports used the same therapy, but in association with coronary artery bypass surgery, among others [7][8][9][10][11][12][13][14][15][16][19][20][21]. Two previous studies [17,18] similar to ours in that respect showed controversial results, one showing an improvement of myocardial perfusion and angina [17] and another only improvement in angina [18].…”

“…Three months after intervention we observed improvements in scintigraphic SSS scores (18.38 ± 7.51 vs. 15.31 ± 7.29, P = 0.003) and SRS (11.92 ± 7.49 vs. 8.53 ± 6.68, P = 0.002) but not in proportion to the areal extent of ischemic Rev Bras Cir Cardiovasc 2010; 25(3): 311-321 of administration of VEGF. Clinical trials bring controversial results, many showing evidence of clinical improvement and angiogenesis [8][9][10][11][12][13][14][15][16][17][18][19] and others showing no differences in myocardial perfusion when compared to their controls [7,20]. Thus, although promising, remain still not completely clear the clinical effects on the myocardium vascularization of the therapy with VEGF in its various forms and ways of administration, justifying further studies.…”

“…The vascular endothelial growth factor (vascular endothelial growth factor -VEGF) has been the focus of several studies [5,6] and its effects are being tested in patients with severe CAD [7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Studies use different doses, vectors and ways Conclusions: The therapy has proved to be safe and feasible in this series of patients.…”

Solid-state laser with fiber-optic output for transmyocardial laser-induced revascularization

“…According to energy and spectral characteristics of the laser, myocardial parameters, and methods of appli cation, TMLR falls into categories [7,8]:…”

Symptomatic Improvement, Increased Life-Span and Sustained Cell Homing in Amyotrophic Lateral Sclerosis After Transplantation of Human Umbilical Cord Blood Cells Genetically Modified with Adeno-Viral Vectors Expressing a Neuro-Protective Factor and a Neural Cell Adhesion Molecule

“…VEGF165 is a predominantly expressed VEGF isoform, which plays a central role in vascular development [15]. In 2002 plasmid construct containing human VEGF165 gene was recommended for clinical use [16].…”