Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride

Varshosaz, Jaleh; Tavakoli, Naser; Kheirolahi, Fatemeh

doi:10.1208/pt070124

Cited by 99 publications

(68 citation statements)

References 38 publications

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“…For tablets from the PG3 batch, first-order kinetics are evident with no constant term. Initial drug release can be rapid because water uptake is higher and faster with guar gum than with other natural gums, such as xanthan gum (23). Similar initial rapid drug release has been reported with soluble drugs salbutamol sulfate (55) and tramadol HCl (23), although the initial release of diltiazem HCl could be controlled (20).…”

Section: Resultsmentioning

confidence: 63%

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Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride

2010

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Abstract. The objectives were to characterize propranolol hydrochloride-loaded matrix tablets using guar gum, xanthan gum, and hydroxypropylmethylcellulose (HPMC) as rate-retarding polymers. Tablets were prepared by wet granulation using these polymers alone and in combination, and physical properties of the granules and tablets were studied. Drug release was evaluated in simulated gastric and intestinal media. Rugged tablets with appropriate physical properties were obtained. Empirical and semi-empirical models were fit to release data to elucidate release mechanisms. Guar gum alone was unable to control drug release until a 1:3 drug/gum ratio, where the release pattern matched a Higuchi profile. Matrix tablets incorporating HPMC provided near zero-order release over 12 h and erosion was a contributing mechanism. Combinations of HPMC with guar or xanthan gum resulted in a Higuchi release profile, revealing the dominance of the high viscosity gel formed by HPMC. As the single rate-retarding polymer, xanthan gum retarded release over 24 h and the Higuchi model best fit the data. When mixed with guar gum, at 10% or 20% xanthan levels, xanthan gum was unable to control release. However, tablets containing 30% guar gum and 30% xanthan gum behaved as if xanthan gum was the sole rate-retarding gum and drug was released by Fickian diffusion. Release profiles from certain tablets match 12-h literature profiles and the 24-h profile of Inderal ® LA. The results confirm that guar gum, xanthan gum, and HPMC can be used for the successful preparation of sustained release oral propranolol hydrochoride tablets.

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Section: Resultsmentioning

confidence: 63%

“…Although it is considered a nongelling gum, it generates a viscous medium due to its tenuous associations (16). Although it is highly swellable, it slows drug release in sustained release formulations (11,23).…”

Section: Introductionmentioning

confidence: 99%

Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride

2010

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“…The result was unexpected since higher amount of drug release is supported by smaller MDT. 25 The observed deviation in MDT values could possibly related to hydration and erosion of polymeric matrix. The drug release in xanthan gum matrix tablets was slower in comparison to HPMC matrix up to 4 h of dissolution studies.…”

Section: Model Dependent and Independent Analysismentioning

confidence: 99%

“…Similarly, drug release from the matrix was also affected by the concentration of gum olibanum in the matrix. Varshosaz et al 25 observed that inclusion of xanthan gum and guar gum has significantly modified tramadol release from HPMC matrix tablets. When two or more polymers are used in a matrix, if they form a semi-or complete interpenetrating network, it form a rigid matrix resulting in slower drug release.…”

Section: Model Dependent and Independent Analysismentioning

confidence: 99%

Evaluation of Hydrophilic Polymers and their Combinations in Formulation of Sustained-Release Matrix Tablets of Water-Soluble Drug

Manjula¹,

Srinatha²,

Sridhar³

2014

IJPER

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Aim of the work: The present study was aimed to investigate matrix-forming property of gum olibanum for sustained-release tablets of tramadol, a freely water-soluble drug. The possible synergistic effect of gum olibanum with hydroxypropyl methylcellulose (HPMC) and xanthan gum, and widely used pharmaceutical excipients on tablet properties was investigated. Methods: Matrix tablets were prepared containing polymers, either alone or in combinations, by wet granulation. Tablets were evaluated for their physico-mechanical properties, drug release and hydration properties. Results: Tablets swelling increased till ~3-4 h this was followed by a decline phase. Drug release from the matrix tablets was dependent on the concentration of gum olibanum. Formulation with drug: gum olibanum in 1:2 released 94.37±2.37% drug in 6 h. The drug release data was analyzed by model dependent and model independent equations. Combination of gum olibanum with HPMC or xanthan gum matrices significantly (p<0.05) modulated drug release, which was reflected by the mean dissolution times (MDTs). Incorporation of lactose induced faster drug release compared to dicalcium phosphate and microcrystalline cellulose. Drug release largely followed first-order kinetics and non-Fickian type of diffusion.

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“…Galactomannans are also essential hydrophilic materials with a variety of properties, such as being nontoxic, biodegradable, inexpensive, and readily available. The potential of galactomannans from different sources to be applied as release-controlling agents has been extensively investigated (Varshosaz et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characteristics of Gradual Fractionation Ingredients of Industrial Galactomannan Gums from Gleditsia microphylla and Cyamopsis tetragonoloba

Liu¹,

Xing²,

Liu³

et al. 2016

BioResources

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Galactomannan in industrial Gleditsia microphylla and guar gum was successfully fractionated by gradual precipitation in an aqueous solution with increasing ethanol concentrations. The molecular properties of each fraction were characterized, and the galactomannans were added to photopolymerized hydrogels to test their effects on mechanical properties and swelling capacity. In the series fractions of guar gum, the sample precipitated from 20% EtOH solution had the highest yield, mannose to galactose ratio, and viscosity, and it had a slightly lower molecular weight than that precipitated by 30% EtOH. Correspondingly, the best tensile property of its photopolymerized hydrogel was finally detected. In terms of G. microphylla gum, the precipitation in 30% EtOH solution achieved the highest yield, M/G ratio, and molecular weight value, and it exhibited the best rheological property of all the samples. The hydrogel with the addition of this sample also had the best mechanical properties despite its lower hydroscopicity than the blank hydrogel. The unique properties of each fraction could probably lead to their use as biodegradable alternatives in different applications.

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Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride

Cited by 99 publications

References 38 publications

Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride

Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride

Evaluation of Hydrophilic Polymers and their Combinations in Formulation of Sustained-Release Matrix Tablets of Water-Soluble Drug

Physicochemical Characteristics of Gradual Fractionation Ingredients of Industrial Galactomannan Gums from Gleditsia microphylla and Cyamopsis tetragonoloba

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