Use of Pistacia lentiscus mastic for sustained‐release system of chlorocresol and benzoic acid for in vitro prevention of bacterial colonization of silicon urinary catheter

Abstract

Significance and Impact of the Study: Urinary catheters are often associated with a high rate of urinary tract infections, especially in hospitalized patients. Therefore, a sustained-release system of chlorocresol and benzoic acid antiseptics was developed to reduce or prevent infection. The antiseptics were varnished using Pistacia lentiscus mastic and this led to a significant reduction in the colonization and biofilm formation of silicon urinary catheters for 72 h. This study indicates the potential benefit of using mastic varnish for sustaining the release of antibacterial agents such as chlorocresol and benzoic acid to reduce and prevent bacterial colonization of urinary catheters.