Use of illicit amphetamines is associated with long-lasting changes in hand circuitry and control

Abstract

Highlights Elevated corticomotoneuronal excitability is present in abstinent male amphetamine users. Abstinent amphetamine users overestimate the grip force required to manipulate novel objects. Elevated excitability and grip force overestimation is present months to years after ending drug use.3 Abstract ObjectiveThe study aim was to determine if use of illicit amphetamines or ecstasy is associated with abnormal excitability of the corticomotoneuronal pathway and manipulation of novel objects with the hand. MethodsThree groups of adults aged 18-50 years were investigated: individuals with a history of illicit amphetamine use, individuals with a history of ecstasy use but minimal use of other stimulants, and non-drug users. Transcranial magnetic stimulation was delivered to the motor cortex and the electromyographic response (motor evoked potential; MEP) was recorded from a contralateral hand muscle. Participants also gripped and lifted a novel experimental object consisting of two strain gauges and an accelerometer. ResultsResting MEP amplitude was larger in the amphetamine group (6M, 6F) than the non-drug and ecstasy groups (p<0.005) in males but not females. Overestimation of grip force during manipulation of a novel object was observed in the amphetamine group (p=0.020) but not the ecstasy group. ConclusionsHistory of illicit amphetamine use, in particular methamphetamine, is associated with abnormal motor cortical and/or corticomotoneuronal excitability in males and abnormal manipulation of novel objects in both males and females. SignificanceAbnormal excitability and hand function is evident months to years after cessation of illicit amphetamine use. 4

Determination of amphetamines, ketamine and their metabolites in hair with high-speed grinding and solid-phase microextraction followed by LC-MS

“…Drug users often take a mixture of drugs to experience the synergistic stimulation produced by various drugs and reduce anxiety and stress. As a consequence, the acute poisoning or pathological damage to multiple systems and organs of the body caused by overdose had happened occasionally [6][7][8][9][10]. In recent years, "Shenxianshui", a kind of oral solution containing a variety of drugs [3] or instant solid "milk tea" were popular in some entertainment venues in China [4].…”