Use of imaging techniques to predict progression in osteoarthritis

Ding, Changhai; Zhang, Yuqing; Hunter, David J.

doi:10.1097/bor.0b013e32835a0fe1

Cited by 43 publications

(31 citation statements)

References 56 publications

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“…MR imaging-defined BMLs, like synovitis, showed dose–response associations with radiographic progression in hand OA already after 2 years, confirming earlier studies on ultrasound-detected synovitis,3 but indicating that BMLs in hand OA, like in knee OA,2 9 are an important additional factor in the disease process. Also, because the presence of BMLs decreases the strength of the association between synovitis and progression, and vice versa.…”

Section: Discussionsupporting

confidence: 81%

“…With the need to develop effective therapies for hand OA, it is important to understand which processes are involved. By the time radiographic damage is visible, much of the disease process already took place 2. Visualisation of the disease process in an earlier stage will facilitate identification of treatment targets and performance of clinical trials.…”

Section: Introductionmentioning

confidence: 99%

“…Magnetic resonance (MR) has the advantage that subchondral bone can be visualised,6 where bone marrow lesions (BMLs) are seen as increased water content in the trabecular bone, compatible with possible inflammation or bone fibrosis and remodelling 7 8. In knee OA studies, BMLs were associated with structural progression 2 9. In hand OA, one MR study (1.0 Tesla (T)) showed that BMLs, next to synovitis, could predict radiographic progression after 5 years 10.…”

Section: Introductionmentioning

confidence: 99%

“…As it is unclear whether underlying processes play the same role in onset (incident) and progression of radiographic osteoarthritic damage,2 we studied both together and apart for their association with baseline MR features. Next to the joint level, with summated MR scores we investigated progression on patient level, the level most clinically relevant.…”

Section: Introductionmentioning

confidence: 99%

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Bone marrow lesions and synovitis on MRI associate with radiographic progression after 2 years in hand osteoarthritis

et al. 2016

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bone marrow lesions and synovitis on MRI associate with radiographic progression after 2 years in hand osteoarthritis

et al. 2016

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“…26 Previous studies reported that mean annual loss of medial tibial cartilage volume loss in patients with knee osteoarthritis was 4.5%. 27 Monthly intake of 50 000 IU of vitamin D would achieve serum 25-hydroxyvitamin D levels greater than 60 nmol/L 28 and this change was estimated to lead to an absolute reduction in medial tibial cartilage loss of 2.2% annually, 8 which was expected to translate into a risk reduction of 44% for total knee replacement over 4 years.…”

Section: Sample Sizementioning

confidence: 99%

Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis

Jin

Jones

Cicuttini

et al. 2016

JAMA

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174

139

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IMPORTANCE Observational studies suggest that vitamin D supplementation is associated with benefits for knee osteoarthritis, but current trial evidence is contradictory.OBJECTIVE To compare the effects of vitamin D supplementation vs placebo on knee pain and knee cartilage volume in patients with symptomatic knee osteoarthritis and low vitamin D levels. DESIGN, SETTING, AND PARTICIPANTSA multicenter randomized, double-blind, placebo-controlled clinical trial in Tasmania and Victoria, Australia. Participants with symptomatic knee osteoarthritis and low 25-hydroxyvitamin D (12.5-60 nmol/L) were enrolled from June 2010 to December 2011. The trial was completed in December 2013. INTERVENTIONS Participants were randomly assigned to receive monthly treatment with oral vitamin D 3 (50 000 IU; n = 209) or an identical placebo (n = 204) for 2 years. MAIN OUTCOMES AND MEASURES Primary outcomes were change in tibial cartilage volume (assessed using magnetic resonance imaging [MRI]) and change in the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score (0 [no pain] to 500 [worst pain]) from baseline to month 24. Secondary outcomes were cartilage defects and bone marrow lesions (assessed using MRI).RESULTS Of 413 enrolled participants (mean age, 63.2 years; 50% women), 340 (82.3%) completed the study. The level of 25-hydroxyvitamin D increased more in the vitamin D group (40.6 nmol/L) than in the placebo group (6.7 nmol/L) (P < .001) over 2 years. There were no significant differences in annual change of tibial cartilage volume or WOMAC pain score. There were no significant differences in change of tibiofemoral cartilage defects or change in tibiofemoral bone marrow lesions. Adverse events (Ն1 per patient) occurred in 56 participants in the vitamin D group and in 37 participants in the placebo group (P = .04). End Point Change, Mean Difference (95% CI) P Value Vitamin D Placebo Tibial cartilage volume, %/y −3.4% −4.2% 0.8% (−0.2% to 1.8%) .13 WOMAC pain −49.9 −35.1 −14.8 (−32.5 to 2.9) .10 Tibiofemoral cartilage defects 0.3 0.5 −0.2 (−0.4 to 0.1) .21 Tibiofemoral bone marrow lesions −0.1 0.3 −0.5 (−0.9 to 0.0) .06CONCLUSIONS AND RELEVANCE Among patients with symptomatic knee osteoarthritis and low serum 25-hydroxyvitamin D levels, vitamin D supplementation, compared with placebo, did not result in significant differences in change in MRI-measured tibial cartilage volume or WOMAC knee pain score over 2 years. These findings do not support the use of vitamin D supplementation for preventing tibial cartilage loss or improving WOMAC knee pain in patients with knee osteoarthritis.

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Association of Body Composition and Hormonal and Inflammatory Factors With Tibial Cartilage Volume and Sex Difference in Cartilage Volume in Young Adults

Antony

Venn

Cicuttini

et al. 2016

Arthritis Care & Research

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Objective. To describe the associations between body composition and hormonal and inflammatory factors measured 5 years prior and tibial cartilage volume in young adults, and to explore if these factors contribute to the sex difference in tibial cartilage volume. Methods. Subjects broadly representative of the young adult Australian population (n 5 328, ages 31-41 years, 47.3% women) were selected. They underwent T1-weighted fat-suppressed magnetic resonance imaging (MRI) of their knees. Tibial cartilage volume was measured from MRI. Sex hormone binding globulin (SHBG) and testosterone in a subset of women and C-reactive protein (CRP) level and fibrinogen in both sexes were measured 5 years prior. Body mass index (BMI), fat mass, and lean mass were calculated from height, weight, and skinfolds. Men had 13% more tibial cartilage volume (500 mm 3 ) than women. The magnitude of this association decreased by 38%, 20%, and 37% after adjustment for lean body mass, fat mass, and fibrinogen, respectively. Conclusion. Body composition, sex hormones, and fibrinogen correlate with knee cartilage volume in young adult life. Sex difference in knee cartilage volume is contributed largely by variations in body composition and/or fibrinogen.

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Use of imaging techniques to predict progression in osteoarthritis

Cited by 43 publications

References 56 publications

Bone marrow lesions and synovitis on MRI associate with radiographic progression after 2 years in hand osteoarthritis

Bone marrow lesions and synovitis on MRI associate with radiographic progression after 2 years in hand osteoarthritis

Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis

Association of Body Composition and Hormonal and Inflammatory Factors With Tibial Cartilage Volume and Sex Difference in Cartilage Volume in Young Adults

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