Use of Immobilized Microbial Membrane Fragments To Remove Oxygen and Favor the Acetone‐Butanol Fermentation

Gòdia, Francesc; Adler, Howard I.; Scott, Charles D.; Davison, Brian H.

doi:10.1021/bp00003a009

Cited by 6 publications

(1 citation statement)

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“…A different concept to enhance oxygen supply to immobilized cells within a fluidized-bed was developed by Chevalier and de la Noue (19881, consisting of the coimmobilization of algae and bacteria in carrageenan beads. Opposite, the immobilized cell particles can be engineered in order to provide anaerobic conditions in a fluidized-bed, introducing the co-immobilization of oxygenreducing microbial membrane fragments together with the cells (Gbdia et al, 1990). In some particular systems, such as those using animal cells, air supply through a bubble-free system is often required in order to avoid cell damage and the fluidized-bed design needs to be modified for this purpose.…”

Section: Introducing Changes In Biocatalyst Particles and Bioreactor mentioning

confidence: 99%

Fluidized‐Bed Bioreactors

Gòdia

Solà

1995

Biotechnology Progress

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Fluidized-bed reactors present a number of advantages that make them an attractive alternative in processes involving biocatalysts. However, fluidized-bed bioreactors are also realtively complex, basically for two reasons. First, their use requires the biocatalyst, commonly cells or enzymes, to be immobilized into or onto a solid support. Second, the hydrodynamic characterization is difficult, especially in those systems where three phases (gas-liquid-solid) are involved. The mathematical model of a fluidized-bed bioreactor needs to take into account those hydrodynamic aspects that will determine the flux model in the reactor. Moreover, the description of other aspects is also required: the mechanisms of transport between the different phases, the kinetic equations for the phenomena taking place in the biocatalytic particles, such as cell growth, product formation, substrate consumption, enzyme deactivation, and the mass balance equations in the reactor. In addition to these aspects, the application of fluidized-bed bioreactors to different kind of processes is also discussed. The potential of this type of bioreactor is also emphasized from the point of view of the different number of possible modifications in the design both of the bioreactor and the biocatalyst particles, in order to enhance its operation.

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Section: Introducing Changes In Biocatalyst Particles and Bioreactor mentioning

confidence: 99%

Fluidized‐Bed Bioreactors

Gòdia

Solà

1995

Biotechnology Progress

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Recent advances and future prospects for increased butanol production by acetone‐butanol‐ethanol fermentation

Tashiro

Yoshida

Noguchi

et al. 2013

Engineering in Life Sciences

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Presently, several researchers are increasingly focusing on producing butanol as the next‐generation fuel by acetone‐butanol‐ethanol (ABE) fermentation. Butanol has many superior characteristics compared to other biofuels, such as ethanol. However, its production by ABE fermentation faces the challenges of low productivity and yield because of product inhibition and heterofermentation, respectively, and thereby, high costs. Until date, molecular biological techniques and fermentation engineering methods have been applied for high butanol production. Although glucose remains the substrate of choice since traditional research, it is now necessary to substitute glucose derived from edible starch to other substrates from low‐cost feedstock, such as agricultural residue. In addition, ABE‐producing clostridia cannot directly produce butanol from lignocelluloses. Therefore, recent research is focusing on pretreatment and enzymatic saccharification of the complex molecules derived from agricultural residue for use as feedstock in butanol production. This article reviews traditional research, including the metabolism patterns and characteristics of ABE‐producing clostridia. Furthermore, this article describes developments in ABE fermentation with respect to the establishment of highly efficient butanol production processes, such as batch, fed‐batch, and continuous cultures, with the introduction of butanol removal, as well as butanol production from lignocellulosic biomasses or alternative substrates to sugars.

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Biobutanol: science, engineering, and economics

Ranjan

Moholkar

2011

Int. J. Energy Res.

151

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SUMMARYAmong several liquid alternative fuels, biobutanol has shown great promise because of its very similar properties to gasoline. This review provides an overview of research activities in acetone-butanol-ethanol (ABE) fermentation over the past two and a half decades. We have addressed seven important facets of ABE fermentation, viz. biochemistry, microbial cultures, alternative substrates, solvent recovery, fermentation mode and reactor designs, mathematical modeling, and economics. Development of mutant strains having higher yield, selectivity and tolerance to inhibition, and search for cheap alternative substrates for fermentation are most important thrust areas in biobutanol production. New and efficient processes have been developed for in situ removal and recovery of the ABE solvents. Several rigorous kinetic and physiological models for fermentation have been formulated, which form useful tool for optimization of the process. These research activities have been reviewed in this paper. Finally, we have summarized studies on the economic viability of large-scale ABE fermentation processes employing various process designs, substrates, and microbial cultures. With the use of new strains, inexpensive substrates, and superior reactor designs, economic potential of ABE fermentation has been found to be highly attractive. Research efforts in science, engineering, and economics of ABE fermentation have brought biobutanol close to commercialization as liquid alternate fuel.

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Use of Immobilized Microbial Membrane Fragments To Remove Oxygen and Favor the Acetone‐Butanol Fermentation

Cited by 6 publications

References 10 publications

Fluidized‐Bed Bioreactors

Fluidized‐Bed Bioreactors

Recent advances and future prospects for increased butanol production by acetone‐butanol‐ethanol fermentation

Biobutanol: science, engineering, and economics

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