Use of indirect immunofluorescence in the lupus erythematosus/lichen planus overlap syndrome: An additional diagnostic clue

Camisa, Charles; Neff, John C.; Olsen, Richard G.

doi:10.1016/s0190-9622(84)70258-1

Cited by 41 publications

(37 citation statements)

References 26 publications

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“…Several overlap dermatoses of autoimmune dermatoses [25, 26] are known to exhibit characteristic features of both diseases without associated neoplasms, however. Recently, single case reports of overlapping antibody specificities in PNP and pemphigus vulgaris [17] and a case of bullous pemphigoid [27] have given evidence of further overlapping entities.…”

Section: Discussionmentioning

confidence: 99%

Graft-versus-Host-Like Mucocutaneous Eruptions with Serological Features of Paraneoplastic Pemphigus and Systemic Lupus erythematosus in a Patient with Non-Hodgkin’s Lymphoma

Mahler¹,

Antoni²,

Anhalt³

et al. 1998

Dermatology

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A 63-year-old male patient spontaneously developed severe erosive orogenital mucositis, palmoplantar and gluteal inflammatory lesions resistant to therapy. The skin lesions clinically and histologically resembled lichen-planus-like graft-versus-host disease. Investigation for an underlying autoimmune or malignant disorder revealed a centrocytic-centroblastic low-grade non-Hodgkin’s lymphoma (according to the Kiel classification) in the bone marrow, mesenterial and iliacal lymphoma. Serological titers were intermittently positive for ANA, anti-Sm/U₁RNP, anti-Ro and anti-dsDNA. Immunoprecipitation of lysates from radiolabeled human keratinocytes with the patient’s serum revealed circulating antibodies against 210-kD (desmoplakin II), 190- and 170-kD antigens but none against the 230-kD antigen or 250-kD desmoplakin I. Under cytostatic chemotherapy the lymphomas showed complete and long-lasting remission, whereas the mucocutaneous lesions persisted. Six years after diagnosis, the mucocutaneous lesions are sufficiently controlled by immunosuppressive therapy. In the presented case, several features of lymphoma-associated dysimmunoreactivity are assumed that bring about the intrinsic production of various autoantibodies typical of paraneoplastic pemphigus and systemic lupus erythematosus.

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Section: Discussionmentioning

confidence: 99%

Graft-versus-Host-Like Mucocutaneous Eruptions with Serological Features of Paraneoplastic Pemphigus and Systemic Lupus erythematosus in a Patient with Non-Hodgkin’s Lymphoma

Mahler¹,

Antoni²,

Anhalt³

et al. 1998

Dermatology

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“…An overlap syndrome with heterogeneous features of LP and lupus erythematosus on clinical, histologic, and immunopathologic analysis has been described, [164][165][166][167][168][169][170] with a report of associated cicatricial alopecia. 164 It is unclear whether this is an autonomous disorder, a form of DLE with LP-like features, or a sign of coexisting LP and lupus erythematosus.…”

Section: Graham-little Syndromementioning

confidence: 99%

“…164 It is unclear whether this is an autonomous disorder, a form of DLE with LP-like features, or a sign of coexisting LP and lupus erythematosus. [166][167][168][169] Acral involvement with verrucous or annular livid red-violet plaques is typical and often affects the palmoplantar surfaces. 168,169 The cicatricial alopecia is a poorly characterized feature 164,167-169 that appeared as erythematous patches succeeded by follicular plugging in one report.…”

Section: Graham-little Syndromementioning

confidence: 99%

“…[166][167][168][169] Acral involvement with verrucous or annular livid red-violet plaques is typical and often affects the palmoplantar surfaces. 168,169 The cicatricial alopecia is a poorly characterized feature 164,167-169 that appeared as erythematous patches succeeded by follicular plugging in one report. 164 Awareness of the existence of this condition is important for management and prognostic purposes, since conversion to SLE has been reported and may not be evident for years.…”

Section: Graham-little Syndromementioning

confidence: 99%

“…164 Awareness of the existence of this condition is important for management and prognostic purposes, since conversion to SLE has been reported and may not be evident for years. 165,168,169 Different diagnostic laboratory techniques have been advocated to help distinguish those with covert LP, but none are readily feasible. 167,168 Pseudopelade of Brocq…”

Section: Graham-little Syndromementioning

confidence: 99%

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