Use of Inflammatory Markers to Guide Cancer Treatment

Clarke, Stephen; Chua, Wei; Moore, Melissa M.; Kao, Steven; Phan, Viet Hong; Tan, Cindy; Charles, Kellie A.; McMillan, Donald C.

doi:10.1038/clpt.2011.122

Cited by 79 publications

(65 citation statements)

References 27 publications

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“…In addition, the combination of hematological components of the systemic inflammatory response, especially the neutrophil-to-lymphocyte ratio (NLR), has been shown to have prognostic value in patients with a variety of cancers [2]. NLR is inexpensive and can be routinely measured in day-to-day oncological practice [2] and thus could be useful for identifying high-risk patients [3]. …”

Section: Introductionmentioning

confidence: 99%

The Neutrophil-to-Lymphocyte Ratio Correlates with Age in Patients with Papillary Thyroid Carcinoma

Liu

Fan

et al. 2015

ORL

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Aim: The aim of this study is to explore the relationship between the neutrophil-to-lymphocyte ratio (NLR) and clinicopathological features in patients with papillary thyroid carcinoma (PTC). Methods: We performed an analysis of 843 patients, including 321 patients with PTC, 83 patients with thyroid adenoma and 439 patients with nodular goiter (NG). Thyroglobulin and thyrotropin were measured in each patient. Neutrophils, lymphocytes, and platelets were counted. Statistical analysis was used to correlate the NLR with demographic and histopathologic characteristics of the patients. Result: Age correlated with NLR and lymphocyte number in patients with PTC and NG. In patients aged >45 years, those with PTC had a higher NLR and a lower lymphocyte count than those with NG. Patients with PTC aged <45 years had a higher leukocyte count and a lower NLR than those aged ≥45 years. Patients with clinical stage I/II PTC had a lower NLR and a higher lymphocyte count than patients with stage III/IV. Conclusions: Younger patients with PTC had a higher lymphocyte count but a lower NLR than older patients with PTC. The NLR and lymphocyte counts were associated with the clinical stage. Thus, a higher NLR and a lower lymphocyte count may be prognostic for stratifying patients with thyroidal goiters and are risk factors of PTC for older patients.

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Section: Introductionmentioning

confidence: 99%

The Neutrophil-to-Lymphocyte Ratio Correlates with Age in Patients with Papillary Thyroid Carcinoma

Liu

Fan

et al. 2015

ORL

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“…In established cancers, inflammatory symptoms such as fevers, sweats, and weight loss occur commonly, and evidence exists that a systemic inflammatory response is predictive of worse outcomes in a number of malignancies, with earlier cancer recurrence and reduced cancer-specific survival (Clarke et al 2011;Moore et al 2010). Inflammation has also been shown to result in slower clearance of anticancer drugs and worse toxicities Kacevska et al 2008).…”

Section: Inflammationmentioning

confidence: 98%

Biomarkers in Metastatic Colorectal Cancer

Diakos

Charles

Chua

et al. 2014

Biomarkers in Cancer

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Significant advances in chemotherapeutics over the past decade have seen a doubling in the median survival time of patients with metastatic colorectal cancer. However, this comes at the cost of toxicity to the patient and financial burden to the community. Biomarkers to predict disease course and treatment response are therefore of major importance so as to allow for the judicious selection of treatment candidates and agents and doses. This review seeks to summarize the current markers available for the prediction of prognosis and treatment response in metastatic colorectal cancer.

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“…There is a growing body of evidence supporting the role of the immune response as an important factor in human cancer development and progression (Clarke et al , 2011). Several markers of systemic inflammatory response, such as the pretreatment plasma fibrinogen level, C-reactive protein, neutrophil- or platelet counts, as well as the neutrophil–lymphocyte ratio (NLR), have been shown to represent independent prognostic factors in various human cancer types (Clarke et al , 2011; Gondo et al , 2012; Hashimoto et al , 2013; Perez et al , 2013; Pichler et al , 2013a, 2013b; Stotz et al , 2013; Szkandera et al , 2013a; Tanaka et al , 2014).…”

mentioning

confidence: 99%

“…Several markers of systemic inflammatory response, such as the pretreatment plasma fibrinogen level, C-reactive protein, neutrophil- or platelet counts, as well as the neutrophil–lymphocyte ratio (NLR), have been shown to represent independent prognostic factors in various human cancer types (Clarke et al , 2011; Gondo et al , 2012; Hashimoto et al , 2013; Perez et al , 2013; Pichler et al , 2013a, 2013b; Stotz et al , 2013; Szkandera et al , 2013a; Tanaka et al , 2014). In particular, the pretreatment NLR might be regarded as an easily measureable and reproducible marker of systemic immune response, having a potential role in renal cell carcinoma as well as in UTUC (Pichler et al , 2013a).…”

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confidence: 99%

Validation of the pretreatment derived neutrophil–lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma

et al. 2014

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Background:The value of a combined index of neutrophil and white cell counts, named derived neutrophil–lymphocyte ratio (dNLR), has recently been proposed as a prognosticator of survival in various cancer types. We investigated the prognostic role of the dNLR in a large European cohort of patients with upper tract urothelial carcinoma (UTUC).Methods:Data from 171 non-metastatic UTUC patients, operated between 1990 and 2012 at a single tertiary academic centre, were evaluated retrospectively. Cancer-specific- (CSS) as well as overall survival (OS) were assessed using the Kaplan–Meier method. To evaluate the independent prognostic significance of the dNLR, multivariate proportional Cox-regression models were applied. Additionally, the influence of the dNLR on the predictive accuracy of the multivariate model was further determined by Harrell's concordance index (c-index).Results:The median follow-up period was 31 months. An increased dNLR was statistically significantly associated with shorter CSS (log-rank P=0.004), as well as with shorter OS (log-rank P=0.002). Multivariate analysis identified dNLR as an independent predictor for CSS (hazard ratio, HR=1.16, 95% confidence interval, CI=1.01–1.35, P=0.045), as well as for OS (HR=1.21, 95% CI=1.09–1.34, P<0.001). The estimated c-index of the multivariate model for OS was 0.68 without dNLR and 0.73 when dNLR was added.Conclusions:Patients with a high pretreatment dNLR could be predicted to show subsequently higher cancer-specific- as well as overall mortality after surgery for UTUC compared with those with a low pretreatment dNLR. Thus, this combined index should be considered as a potential prognostic biomarker in future.

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Use of Inflammatory Markers to Guide Cancer Treatment

Cited by 79 publications

References 27 publications

The Neutrophil-to-Lymphocyte Ratio Correlates with Age in Patients with Papillary Thyroid Carcinoma

The Neutrophil-to-Lymphocyte Ratio Correlates with Age in Patients with Papillary Thyroid Carcinoma

Biomarkers in Metastatic Colorectal Cancer

Validation of the pretreatment derived neutrophil–lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma

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