Use of injectable platelet‐rich fibrin in the treatment of plasma cell mucositis of the oral cavity refractory to corticosteroid therapy: A case report

Abstract

Plasma cell mucositis (PCM) is a rare benign disease affecting adults characterized by an erythematous mucosa, an epithelial hyperplasia, and a dense submucosal infiltration of mainly mature plasma cells. PCM has been treated with topical, intralesional, and systemic corticosteroids, antibiotics, and topical cyclosporin with unreliable results and questionable benefits. Here, we present a case of PCM, refractory to previous treatments, treated with i‐PRF (injectable platelet‐rich fibrin) injections. The infiltrations were performed once a week for 2 months. There were no adverse reactions to the treatment. The pain gradually reduced until the score of zero at the fourth infiltration, and the patient remained free of pain during the whole study period. Clinically, we did not obtain a complete healing of the lesion, but a reduced perilesional inflammatory infiltrate was observed at a distance. Therefore, we can conclude that i‐PRF has been effective in the management of pain in PMC but does not result in complete healing of the disease.

An Uncommon Case of Plasma Cell Mucositis of the Tongue in a Young Man

“…Several times, PCM lesions can enter into differential diagnosis with squamous cell carcinoma (SCC) [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]; in literature, there are cases in which a differential diagnosis was made with oral carcinoma and there is a case report where a SCC arose from a mucosal plasmacytosis [13]. Therefore, a correct diagnosis and adequate management of the disease are essential.…”

“…However, in literature, there are some reported cases where the use of PRF injections is associated with cortisone therapy [6]. The benefit of PRF is to allow a continuous release of growth factors, inducing neoangiogenesis and fibroblast activations.…”

Autologous platelet‐rich fibrin injections in the management of facial cutaneous sinus tracts secondary to medication‐related osteonecrosis of the jaw

“…Efficacy of APCs in promoting wound healing and tissue regeneration is at the center of a recent academic debate 10 . The possible acceleration in the healing of soft and hard tissues represents the rationale for the use of platelet concentrates in the treatment of chronic wounds and MRONJ 8,11,12 …”

Methotrexate-induced Plasma Cell Mucositis: A Case Report of a Previous Undescribed Correlation

“…PCM is a very rare immunological disorder of the upper aerodigestive tract that can affect the oral cavity [2]. This case report is the first one that describes the onset of PCM associated to Methotrexate therapy, thus different from Methotrexate-induced mucocutaneous ulcer [3].…”