Background: Malaria has remained one of the leading causes of morbidity and mortality in children despite effective preventive and treatment modalities. This study is aimed at looking at the malaria preventive practices among under-five children in three Niger Delta states in Nigeria and comparing the differences among them if any. Methods: This was a cross sectional study carried out over six months from 1 st January to 30 th June 2019 in public health facilities among under-five children in three South-South states (Akwa Ibom, Delta and Rivers) of Nigeria. Using a stratified sampling method, children were recruited from 36 health facilities in the three states. A pretested interviewer administered questionnaire was used to harvest relevant information on socio-demographic characteristics of the subjects and informants and malaria preventive practices. Obtained data was analysed using SPSS version 22 and results are presented in prose and frequency tables. Chi-square and Fischer's exact were used for comparison of categorical variables, while a p-value of <0.05 was considered statistically significant. Results: A total of 3144 children participated in the study: 1661 (52.8%) were males while 1483 (47.2%) were females. Children less than 2 years represented 77.6% of the study participants while the mean age was 1.72 ± 1.06 years. Mothers constituted over 80% of the informants in all the states.