This comprehensive review delves into the evolving landscape of Nepalese agriculture, where 60.4% of the population is engaged in farming. As globalization reshapes the sector, Nepalese agriculture grapples with the transition from subsistence to market-oriented practices, marked by the widespread use of high-yielding varieties and chemical inputs. This shift, while addressing immediate food demands, has led to severe consequences, including soil degradation, loss of biodiversity, and threats to environmental sustainability. In response, traditional plant protection practices emerge as a beacon of hope, offering eco-friendly and sustainable alternatives. The review explores a plethora of indigenous strategies deployed by Nepalese farmers, ranging from handpicking pests to innovative approaches like the use of wooden ash, urine, dung, and bio-pesticides such as Jholmal. These methods not only provide immediate pest control but also align with sustainable ecological principles. The review underscores the importance of traditional practices like crop rotation, flooding, etc. providing a comprehensive overview of indigenous knowledge. However, amidst their effectiveness, these practices face the peril of extinction due to insufficient documentation and limited integration into mainstream research. The study advocates for a concerted effort to protect and promote these indigenous practices, not only for their role in sustainable plant protection but also as vital elements of Nepal’s cultural and agricultural heritage.