Use of insulin in diabetes: a century of treatment

Shahani, Savita; Shahani, Lokesh R

doi:10.12809/hkmj154557

Cited by 14 publications

(12 citation statements)

References 31 publications

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“…Type 1 diabetes (T1D) is characterized by progressive autoimmune destruction of insulin‐producing pancreatic β cells, mandating use of exogenous insulin . Insulin, through its myriad of physiological effects, acts as a double‐edged sword .…”

Section: Introductionmentioning

confidence: 99%

“…Type 1 diabetes (T1D) is characterized by progressive autoimmune destruction of insulin-producing pancreatic β cells, mandating use of exogenous insulin. 1,2 Insulin, through its myriad of physiological effects, acts as a double-edged sword. 3 On the one hand, intensive insulin therapy (IIT) decreases the incidence of microvascular complications, 4 but on the other hand, it promotes weight gain.…”

Section: Introductionmentioning

confidence: 99%

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Intensive multidisciplinary weight management in patients with type 1 diabetes and obesity: A one‐year retrospective matched cohort study

Mottalib

Tomah

Hafida

et al. 2018

Diabetes Obesity Metabolism

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intensive multidisciplinary weight management in patients with type 1 diabetes and obesity: A one‐year retrospective matched cohort study

Mottalib

Tomah

Hafida

et al. 2018

Diabetes Obesity Metabolism

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“…However, T1DM requires insulin replacement via injection of hormone or Islet transplantation. Novel delivery via oral, inhaled and sublingual routes are the topic of intense current investigation (Shahani and Shahani, 2015). T2DM is considerably more amenable to therapeutic drug intervention and is treated with insulin secretagogues e.g.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Plants used to treat diabetes in Sri Lankan Siddha Medicine – An ethnopharmacological review of historical and modern sources

Sathasivampillai

Rajamanoharan

Munday

et al. 2017

Journal of Ethnopharmacology

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Cite this article as: Saravanan V. Sathasivampillai, Pholtan R.S. Rajamanoharan, Michael Munday and Michael Heinrich, Plants used to treat diabetes in Sri Lankan Siddha Medicine -an ethnopharmacological review of historical and modern sources, Journal of Ethnopharmacology, http://dx.doi.org/10. 1016/j.jep.2016.07.053 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Abstract Introduction and background:In recent decades diabetes mellitus has become a considerable health problem in countries like Sri Lanka and results in an increasing economic burden hampering the social and economic development of these countries. About 60 to 70 % of the rural population in Sri Lanka rely on indigenous medicinal systems as their main source for primary health care. Siddha (Tamil) Medicine is one of the four Sri Lankan traditional medicinal systems and it is practised mostly in the eastern and northern provinces of Sri Lanka where the majority of Tamils reside. Aim:The foundation of this study is a documentation of plant species recorded in historical and modern Sri Lankan Siddha Medical documents used to treat diabetes. Based on the systematic documentation and analysis of Siddha concepts about diabetes and its signs and preparations used to treat diabetes in Sri Lankan Siddha Medicine, the plant species included in these preparations (excluding globally or very widely used, very well studied species) were evaluated in terms of the current stateof-the-art about these species' pharmacology and effectiveness in order to lay a foundation for their further development. Method:Historic and modern Sri Lankan university texts books in Tamil were used as sources for information on diabetes Siddha concepts and antidiabetic Sri Lankan Siddha Medicine preparations. Information on the known antidiabetic effects of extracts and compounds obtained from these species were used in order to assess the current state of the art of these species. Results and discussion: Information of ingredients, preparation methods, amount of ingredients used, and dosages of 60 antidiabetic Sri Lankan Siddha Medicine preparations were obtained. Animal parts including marine organisms, inorganic substances, and plants are the three types of ingredients used. Overall 171 plant species in 73 families were documented. Senna auriculata (L.) Roxb. (Fabaceae) was identified as the most frequently cited species. Globally distributed and very well studied plants were excluded in the pharmacological and clinical literature review which includes 123 plant species. The majority (48 %) of the plant species reviewed were studied up to in vivo level as...

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“…The disease is characterized by a lack of insulin due to autoimmune destruction of insulin producing pancreatic β cells. It is also used to treat type 2 diabetes mellitus, which is caused by insulin resistance and a deficiency in insulin secretion . Werther et al found a high distribution of insulin receptors within the rat brain, including the olfactory bulb, by using techniques of in vitro audioradiography and densitometry .…”

Section: Zinc Gluconate Copper Gluconate Magnesium Gluconatementioning

confidence: 99%

Influence of drugs on smelling capacity. A review

Thiermann¹,

Buchbauer²

2017

Flavour & Fragrance J

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A well‐functioning sense of smell is essential not only for human wellbeing and the quality of life, it is also important to protect the organism from harmful influences it is exposed to, such as gas, toxic agents or rotten food. Various drugs interfere with human olfaction and are able to elicit olfactory dysfunction, but little is known about the underlying mechanisms. To date, a wide range of drugs have not been sufficiently investigated with respect to their impact on olfaction. This review provides an overview of drugs that have been identified as inducing olfactory disorders and discusses underlying causes and mechanisms.

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Use of insulin in diabetes: a century of treatment

Cited by 14 publications

References 31 publications

Intensive multidisciplinary weight management in patients with type 1 diabetes and obesity: A one‐year retrospective matched cohort study

Intensive multidisciplinary weight management in patients with type 1 diabetes and obesity: A one‐year retrospective matched cohort study

Plants used to treat diabetes in Sri Lankan Siddha Medicine – An ethnopharmacological review of historical and modern sources

Influence of drugs on smelling capacity. A review

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