Use of Integra in oral reconstruction: a case series

Gonzálvez, Laura Rúa; Alvarez, Lilian; Gómez, Arturo; Rodríguez, J.C. De Vicente; Peña, Ignacio

doi:10.1016/j.oooo.2017.11.003

Cited by 9 publications

(8 citation statements)

References 9 publications

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“…12 Rua Gonzálvez et al (2018) described its successful use in small intraoral oncologic defects. 11 In contrast, cases included in this series varied in intraoral location and surgical defect sizes, ranging from 1 to 5cm, as well as one case with an oroantral fistula. Some surgical defects were confined to keratinized tissues overlying alveolar ridges that could be easily immobilized, while others were located on highly movable oral tissues including buccal mucosa, floor of the mouth and tongue.…”

Section: Discussionmentioning

confidence: 95%

“…Beech and Farrier (2016) described a case of mandibular osteoradionecrosis defect that was reconstructed using an Integra ® regeneration system 12 . Rua Gonzálvez et al (2018) described its successful use in small intraoral oncologic defects 11 . In contrast, cases included in this series varied in intraoral location and surgical defect sizes, ranging from 1 to 5cm, as well as one case with an oroantral fistula.…”

Section: Discussionmentioning

confidence: 97%

“…Despite its widespread clinical usage, a literature search revealed only 2 published clinical reports on intraoral application of Integra® skin substitutes. 11,12 Beech and Farrier (2016) described a case of mandibular osteoradionecrosis defect that was reconstructed using an Integra ® regeneration system. 12 Rua Gonzálvez et al (2018) described its successful use in small intraoral oncologic defects.…”

Section: Discussionmentioning

confidence: 99%

“…This case series illustrates the great utility of Integra® bilayer wound matrix for reconstruction of small to large intraoral oncologic surgical defects as well as its versatility on movable and nonmovable mucosa. Despite its widespread clinical usage, a literature search revealed only 2 published clinical reports on intraoral application of Integra® skin substitutes 11,12 . Beech and Farrier (2016) described a case of mandibular osteoradionecrosis defect that was reconstructed using an Integra ® regeneration system 12 .…”

Section: Discussionmentioning

confidence: 99%

“…Integra® skin regeneration systems (Integra LifeSciences, Plainsboro, New Jersey) have found widespread application for reconstruction of intraoral surgical defects that do not mandate a regional or free flap reconstruction. Integra® bilayer wound matrix is one such regeneration matrix that has found widespread use for intraoral application but is sparsely reported in the literature 11,12 . This bilayer matrix is a composite graft with an inner porous layer made of cross‐linked bovine tendon type I collagen and chondroitin‐6‐sulfate glycosaminoglycan, and an outer layer made of a thin nonresorbable, semi‐permeable polysiloxane (silicone sheet).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Reconstruction of intraoral oncologic surgical defects with Integra^® bilayer wound matrix

Srivastava¹,

Maniakas

Myers

et al. 2020

Clinical Case Reports

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show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Reconstruction of intraoral oncologic surgical defects with Integra^® bilayer wound matrix

Srivastava¹,

Maniakas

Myers

et al. 2020

Clinical Case Reports

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show abstract

Tissue origin matters: Maintenance of tenogenic phenotype on the tendon and not skin collagen‐derived devices

Sorushanova

Tsiapalis

Skoufos

et al. 2022

MedComm – Biomaterials and Applications

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Recent data suggest that collagen retains the memory of the tissue that it derives from. With this in mind, collagen (from bovine skin and tendon) sponges were fabricated with different crosslinking densities, and their physicochemical and biological properties were assessed. As the crosslinking density was increased, the resistance to collagenase digestion, denaturation temperature, compressive stress, and compressive modulus was significantly increased and the free amine content, % swelling, and human dermal fibroblast cytocompatibility were significantly reduced. The tendon‐collagen‐derived scaffolds exhibited significantly higher compressive stress and compressive modulus values and induced significantly higher human tenocyte DNA concentration and metabolic activity than the skin‐collagen‐derived scaffolds. In human tenocyte cultures on day 14, the 1 mM 4‐arm polyethylene‐glycol succinimidyl glutarate tendon‐collagen‐derived collagen sponges induced significantly higher collagen type III synthesis (as expected at early stages of physiological tendon healing) and downregulated actin alpha 2 (associated with myofibroblast differentiation) and the skin‐collagen‐derived collagen sponges induced significantly higher collagen type IV synthesis (found primarily at the dermal‐epidermal junction) and upregulated prolyl 4‐hydroxylase subunit alpha‐1 (associated with collagen biosynthesis and constitutes a target for antifibrotic compounds). Our data indicate that the tissue from which collagen is extracted should be considered in the development of medical devices.

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The Feasibility and Outcome of Integra® Bilayer Matrix in the Reconstruction of Oral Cavity Defects

Mansour,

Nesbitt,

Khanjae

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveTo evaluate the feasibility, safety, and failure rate of Integra® Bilayer Wound Matrix (Integra) in the reconstruction of oral cavity defects.Study DesignRetrospective cohort study.SettingAll study information was collected from a single academic tertiary care hospital.MethodsSubjects included adult patients who underwent oral cavity resection and immediate subsequent reconstruction with Integra® Bilayer Wound Matrix at MD Anderson Cancer Center between the years 2015 and 2020. The following variables were collected: patient's demographics, comorbidities, disease stage, treatment and reconstruction modalities, and surgical outcome from the medical records. Statistical analysis included distribution analysis for all collected parameters and Pearson's χ2 tests to find correlation between variables and take rate of Integra.ResultsEighty‐three patients underwent reconstruction with Integra® Bilayer Wound Matrix dressing. Average age was 66 years old. Thirty‐nine patients (47%) had history of previous resections for oral cavity tumors. Fourteen patients (17%) had history of radiation therapy to the Head and Neck region. Most common pathology was invasive squamous cell carcinoma (75%) followed by dysplasia (12%). Complete wound healing with good cellular integration occurred in 83 patients (96%) with only 3 failures requiring additional surgery. Reconstruction of mandibulectomy defects was associated with increased risk of dehiscence and bone exposure (0.66, P = .03).ConclusionThis study shows promising results with high take rate of Integra® Bilayer Wound Matrix dressing in the reconstruction of various oral cavity defects. We encourage surgeons to adopt this technique as a viable and versatile option into the reconstruction ladder of oral cavity defects.

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Use of Integra in oral reconstruction: a case series

Cited by 9 publications

References 9 publications

Reconstruction of intraoral oncologic surgical defects with Integra^® bilayer wound matrix

Reconstruction of intraoral oncologic surgical defects with Integra^® bilayer wound matrix

Tissue origin matters: Maintenance of tenogenic phenotype on the tendon and not skin collagen‐derived devices

The Feasibility and Outcome of Integra® Bilayer Matrix in the Reconstruction of Oral Cavity Defects

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Use of Integra in oral reconstruction: a case series

Cited by 9 publications

References 9 publications

Reconstruction of intraoral oncologic surgical defects with Integra® bilayer wound matrix

Reconstruction of intraoral oncologic surgical defects with Integra® bilayer wound matrix

Tissue origin matters: Maintenance of tenogenic phenotype on the tendon and not skin collagen‐derived devices

The Feasibility and Outcome of Integra® Bilayer Matrix in the Reconstruction of Oral Cavity Defects

Contact Info

Product

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Reconstruction of intraoral oncologic surgical defects with Integra^® bilayer wound matrix

Reconstruction of intraoral oncologic surgical defects with Integra^® bilayer wound matrix