Use of integrins to date the endometrium

Lessey, Bruce A.; Castelbaum, Arthur J.; Wolf, Lynda; Greene, Wendy; Paulson, Mary; Meyer, William R.; Fritz, Marc A.

doi:10.1016/s0015-0282(99)00604-4

Cited by 127 publications

(57 citation statements)

References 31 publications

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“…1), where i = intensity of staining with a value of 1, 2, or 3, (weak, moderate or strong, respectively) and Pi the percentage of stained mammary adipose cells for each intensity, varying from 0 to 100%. This HSCORE has been previously reported [17,18].…”

Section: Immunohistochemistrymentioning

confidence: 84%

Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-β1 and TNF-α

Guerrero

Tobar

Cáceres

et al. 2009

Breast Cancer Res Treat

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In carcinomas such as those of breast, pancreas, stomach, and colon, cancer cells support the expansion of molecular and cellular stroma in a phenomenon termed desmoplasia, which is characterized by a strong fibrotic response. In the case of breast tissue, in which stroma is mainly a fatty tissue, this response presumably occurs at the expense of the adipose cells, the most abundant stromal phenotype, generating a tumoral fibrous structure rich in fibroblast-like cells. In this study, we aimed to determine the cellular mechanisms by which factors present in the media conditioned by MDA-MB-231 and MCF-7 human breast cancer cell lines induce a reversion of adipose cells to a fibroblastic phenotype. We demonstrated that soluble factors generated by these cell lines stimulated the reversion of mammary adipose phenotype evaluated as intracellular lipid content and expression of C/EBP alpha and PPAR gamma. We also demonstrated that exogenous TGF-beta 1 and TNF-alpha exerts a similar function. The participation of both growth factors, components of media conditioned by tumoral mammary cells, on the expression and nuclear translocation of C/EBP alpha and PPAR gamma was tested in 3T3-L1 cells by interfering with the inhibitory effects of media with agents that block the TGF-beta 1 and TNF-alpha activity. These results allow us to postulate that TGF-beta 1 and TNF-alpha present in this media are in part responsible for this phenotypic reversion.

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Section: Immunohistochemistrymentioning

confidence: 84%

Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-β1 and TNF-α

Guerrero

Tobar

Cáceres

et al. 2009

Breast Cancer Res Treat

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show abstract

“…This semiquantitative analysis has been shown to have high intra-observer and inter-observer reproducibility. 16 In addition to H-score, we also used the percentage of stained cells as a criterion to measure FASN expression in tissue sections.…”

Section: Case Selection and Immunohistochemistrymentioning

confidence: 99%

Trophoblastic Neoplasms Express Fatty Acid Synthase, Which May Be a Therapeutic Target via Its Inhibitor C93

Ueda

Mao

Kuhajda

et al. 2009

The American Journal of Pathology

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“…Collagen " 1 -a 1, a 2 , a 3 , a ν Fibronectin " 1 -a 3 , a 4 , a 5 " 3 -a ν , a IIb " 6 -a ν " 7 -a 4 Laminin " 1 -a 1 , a 2 , a 3 , a 6 , a 7 " 3 -a ν " 4 -a 6 Vitronectin " 1 -a ν " 3 -a ν , a IIb " 5 -a ν Non-identified " 1 -a 8 , a 9 " 8 -a ν implantation, integrins a 1 " 1 , a 4 " 1 and a ν " 3 predominate (Lessey et al 1994(Lessey et al , 2000. The a 1 " 1 integrin is expressed on the glandular epithelium between days 15 and 28 of the menstrual cycle, and the a 4 " 1 integrin appears on the glandular epithelium for the first time just after ovulation, disappearing on day 24.…”

Section: Integrinsmentioning

confidence: 99%

Expression of adhesion molecules during normal pregnancy

et al. 2007

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We review the available information regarding the role of adhesive molecules as potential participants in the complex events of fertilization, embryogenesis, implantation and placentation. Studies that specifically relate to the expression and modulation of adhesive molecules in fertilization, embryogenesis, and implantation have been identified in the literature and by Medline searches. Cell-cell and cell-extracellular matrix interactions play a critical role in various developmental processes and in the cascade of events that lead to implantation and to the normal development of the fetus during pregnancy. Adhesion molecules influence, directly or indirectly, numerous aspects of cell behaviour, cell migration, cell growth, cell survival, cell proliferation, angiogenesis, invasion and metastasis.

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Use of integrins to date the endometrium

Cited by 127 publications

References 31 publications

Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-β1 and TNF-α

Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-β1 and TNF-α

Trophoblastic Neoplasms Express Fatty Acid Synthase, Which May Be a Therapeutic Target via Its Inhibitor C93

Expression of adhesion molecules during normal pregnancy

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