Use of intense pulse light for acne vulgaris in Indian skin – a case series

Mohanan, Saritha; Parveen, B; Malathy, Priyavathani Annie; Gomathi, Nellainayagam

doi:10.1111/j.1365-4632.2011.05295.x

Cited by 21 publications

(21 citation statements)

References 18 publications

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“…These results were comparable with a study of Rojanamatin and Choawawanich who evaluated 14 patients and observed mild and reversible side effects [16] . Mohanan et al evaluated 10 patients in his trial and observed no adverse effects [17] . It is further established that with standard care, there is no increased risk of side effects on Asian skin.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of intense pulsed light in the treatment of mild-to-moderate acne vulgaris

2017

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Acne vulgaris is a very common chronic inflammatory disease of pilosebaceous units. It can be associated with considerable loss of self-esteem and psychological morbidity when left untreated. With the emergence of lasers and intense pulsed light, long-term reduction of acne lesions is now possible. The success of these optical devices depends on the selected parameters and biologic variables of patient. The objective of this study is to determine the efficacy and safety of intense pulsed light (IPL) in the treatment of mild-to-moderate acne vulgaris. This interventional study was conducted for a period of one year after approval of synopsis. A total of 75 patients of mild-to-moderate acne vulgaris were included through non-probability, convenience sampling. Patients were subjected to intense pulsed light (IPL) therapy once a week for four weeks. Digital photography was done at the baseline and at the sixth week. Follow-up was done after two weeks of completion of four sessions. Repeated measurement ANOVA was used for significance of IPL at six weeks of follow-up. The p value < 0.05 was taken as significant. IPL was effective in 52% of the patients. Out of all cases, 6 (8%) showed excellent results. 33 (44%) showed >50% reduction with therapy. Percentage reduction was observed as 49% ± 20% at final follow-up. Papules count was reduced from 11.95 ± 2.89 to 6.69 ± 2.96, pustules count was reduced from 2.55 ± 1.54 to 0.79 ± 1.02 from baseline to final follow-up visit. 16 subjects showed mild erythema that resolved within 24 h. None of the patients showed any severe side effects at final follow-up visit. We conclude from the results of this study that IPL is safe and efficacious in more than half of the patients in the treatment of mild and moderate acne vulgaris. A long-term follow-up is required to determine long-term safety on skin following such procedures.Keywords: Acne vulgaris; intense pulsed light; pustules; papules Citation: Khan WZ, Butt G, Altaf F. Efficacy and safety of intense pulsed light in the treatment of mild-to-moderate acne vulgaris. J Surg Dermatol 2017; 2(T1): 152-157; http://dx

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of intense pulsed light in the treatment of mild-to-moderate acne vulgaris

2017

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“…While lasers have also been employed in acne treatment, randomized controlled trials with a reasonable number of patients are scarce, and moreover their efficacy and safety profiles are not always optimal …”

Section: Introductionmentioning

confidence: 99%

An extension of a multicenter, randomized, split‐face clinical trial evaluating the efficacy and safety of chromophore gel‐assisted blue light phototherapy for the treatment of acne

et al. 2017

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A variety of laser/light-based devices have been reported to be effective for the treatment of acne, yet no long-term data on efficacy and safety have been published. A first 12-week clinical trial ("Main trial") recently demonstrated that the KLOX BioPhotonic System, an LED blue light device using photo-converter chromophores, can significantly improve moderate and severe facial acne vulgaris with an excellent safety profile. This Extension trial followed the Main trial, using the same BioPhotonic System, with the same dose and instructions for use, on patients having already completed treatment in the Main trial. Main objectives of this open-label long-term extension 12-week study were to evaluate the efficacy of the KLOX BioPhotonic System on the untreated hemiface during the Main trial, as well as the duration of response on the hemiface treated during the first 12-week Main trial. Despite their young age (mean age: 21.6 years) and their 12-week participation in the Main trial, 49 (54.4%) of the total number of patients who participated in the Main trial enrolled in this additional 12-week Extension trial. Baseline grading of acne was performed with the Investigator's Global Assessment (IGA) scale. For each patient, the hemiface randomly selected as a control during the Main trial received 6 weeks of treatment (twice weekly) and was then followed up for an additional 6 weeks. The first hemiface treated in the Main trial was consequently observed throughout the Extension trial, allowing for a further 12-week assessment of outcomes (total 24 weeks). In light of an additional 12 weeks of treatment on the contralateral face, the patient compliance rate was excellent, with 91.9% of the total number of patients receiving at least 80% of the treatments.Patients with a baseline IGA grade of 2 (mild) on the treated hemiface demonstrated a success rate of 58.3 and 66.7% at weeks 6 and 12, respectively. At these same time points, subjects with a baseline IGA grade of 3 (moderate) demonstrated a success rate of 81.8 and 90.0%. Patients with a baseline IGA grade of 4 (severe) demonstrated a success rate of 100% at both week 6 and week 12. When evaluating the originally treated hemifaces from the Main trial, the rate of return to baseline at 24 weeks was calculated to be 15.5%. This latter outcome confirmed the long duration of effect following treatment.The patient safety profile was also excellent, with very few related adverse events. The BioPhotonic System, which is comprised of LED blue light phototherapy and photoconverter chromophores, provides long-term efficacy and safety in the treatment of acne vulgaris, with a rate of compliance above what is generally observed in a young population of patients suffering from acne vulgaris, especially in light of sequential enrollment in a study treating one hemiface.

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“…In our study at the end of 6 treatment sessions (6 weeks), the mean percentage reduction in total lesion count was 74.1% from baseline. In a similar study done by Mohanan S et al 19 the mean percentage reduction was 64.7% at the end of five treatment sessions.…”

Section: Discussionmentioning

confidence: 64%

“…In the present study, at the end of six treatment sessions (week 6), 27 patients (90.0%) had excellent inflammatory lesion clearance (>75%), 3 patients (10.0%) had good inflammatory lesion clearance (51-75%). In a similar study conducted by Mohanan S et al; 19 out of 8 patients, two patients had excellent inflammatory acne clearance (>75%) and five patients had good acne clearance (51%-75%) at the end of five treatment sessions of IPL. At the end of six treatment sessions (week 6), 17 patients (56.7%) had excellent total lesion clearance (>75%), 13 patients (43.3%) had good total lesion clearance (51-75%).…”

Section: Discussionmentioning

confidence: 90%

“…At the end of six treatment sessions (week 6), 17 patients (56.7%) had excellent total lesion clearance (>75%), 13 patients (43.3%) had good total lesion clearance (51-75%). However, similar study done by Mohanan S et al 19 wherein seven patients had 51-75% reduction in lesion count (good response) and one had moderate response at the end of five treatment sessions; Khan W Z et al 18 reported 6 patients (8%) having excellent response and 33 patients (44%) showing good response at the end of treatment.…”

Section: Discussionmentioning

confidence: 90%

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Normative data of median nerve conduction in the state of Haryana

2020

IJN

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Introduction: Acne vulgaris is a self-limiting, chronic inflammatory disorder of pilosebaceous follicle seen commonly among young adults with significant psychological and social impact. Multiple topical and systemic therapies targeting various pathogenic factors of acne are available, in spite of which patients are unable to achieve adequate and long term control of acne. Therefore, there is a need for newer therapeutic modalities that are more effective, convenient and safe. In this regard, one of the emerging treatment modalities is intense pulse light (IPL) therapy which meet the need for novel acne treatment. Objectives: To evaluate the efficacy and safety of intense pulse light (IPL) therapy in the treatment of facial acne vulgaris. Materials and Methods: A total of 30 patients in age group of 18-40 years with facial acne vulgaris meeting the defined inclusion and exclusion criteria were enrolled in this study after taking an informed consent and approval of institutional ethical committee. All the patients with facial acne vulgaris grade 1-4 were subjected to monotherapy with IPL. Convention fluence of 10 J and 410 nm cut off filter was used at first sitting. IPL was administered weekly for 6 weeks, and the fluence was increased by 1 J every session. Acne severity assessment was done at initial visit (week 0) and at the end of last treatment session (week 6) based on Michaelssons acne severity index. Also at the initial visit, at each sitting and at the end of final treatment session (6 sessions), lesions count (counting the number of comedones, papules, pustules, cysts and nodules) were undertaken. Percentage reduction in the number of lesions were calculated at each visit and at end of final treatment session (6th session) and graded as mild (0-25%), moderate (26-50%), good (51-75%), and excellent (76-100%) improvement relative to baseline. Results: At the end of 6 treatment sessions (6 weeks), the mean percentage reduction of non-inflammatory, inflammatory and total lesion counts were 60.2%, 80.4%, 74.1% relative to baseline respectively. Mean Michaelssons acne severity index at baseline (0 week) was 50.83 and at the end of six treatment sessions was 10.20. The improvement in acne severity score was found to be statistically significant (p=.000). No significant adverse effects were noticed. Conclusion:The results of this study show that IPL is effective and safe for management of facial acne vulgaris grade 1 -4 with minimal reversible side effects.

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Use of intense pulse light for acne vulgaris in Indian skin – a case series

Abstract: IPL serves a useful role in the treatment of acne vulgaris and could reduce treatment costs and pill burden. There is no increased risk of side effects with IPL on Indian skin with standard care.

Cited by 21 publications

References 18 publications

Efficacy and safety of intense pulsed light in the treatment of mild-to-moderate acne vulgaris

Efficacy and safety of intense pulsed light in the treatment of mild-to-moderate acne vulgaris

An extension of a multicenter, randomized, split‐face clinical trial evaluating the efficacy and safety of chromophore gel‐assisted blue light phototherapy for the treatment of acne

Normative data of median nerve conduction in the state of Haryana

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