Use of intraarticular injections of platelet-rich plasma in the treatment of knee osteoarthritis: A review article

Baloch, Naveed; Hasan, Obada; Baig, Zain; Abdullah, Umme-e-Hani; Atif, Mohammad; Ohuchi, Hiroshi

doi:10.4081/or.2019.7747

Cited by 6 publications

(4 citation statements)

References 54 publications

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“…Cubital veins are used for sampling. An anticoagulant such as acid citrate dextrose is then added to the collected sample [27][28][29] . Blood is then passed through two cycles of centrifugation, the rst of which is done at 1600rpm for 15 minutes which strati es blood into three strata i.e.…”

Section: Preparation Of Prpmentioning

confidence: 99%

“…A second cycle is done at 2800 rpm for 7 minutes) which concentrates platelet-rich and platelet-poor plasma components. This process requires the usage of a manual centrifuge [27][28][29] . Other than the uid PRP, there is a solid one as well which comprises a 3d-matrix and is manually compressed and attened to form a membrane.…”

Section: Preparation Of Prpmentioning

confidence: 99%

“…Other than the uid PRP, there is a solid one as well which comprises a 3d-matrix and is manually compressed and attened to form a membrane. The membrane, once formed, can be used for up to three hours 21,24,27 .…”

Section: Preparation Of Prpmentioning

confidence: 99%

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Platelet-Rich Plasma-A Safe and Cost-effective Dural Sealant in Spinal Surgeries-A Systematic Review

Aziz,

Yaqoob,

Tariq

et al. 2024

Preprint

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Introduction Incidental durotomy (ID) is a common complication of otherwise rewarding lumbar decompression surgeries. An effective water-tight closure of the dura can potentially avoid cerebrospinal fluid (CSF) leakage and its dreaded sequel. Several sealants, grafts, and patches are used; however, the cost constrains its utility in resource-limited settings. Platelet-rich plasma (PRP) has been found effective in wound healing and adhesive properties and hence a potential adjunct for watertight closure of dura. This systematic review was conducted to highlight the existing literature on the utility of PRP in spinal procedures for the managing of CSF leaks. Methods The review was conducted based on the PRISMA guidelines. After a comprehensive database search through three databases (PubMed, Scopus, and Cochrane Library), studies assessing the role of PRP in CSF leaks or for the water-tight closure of dura were included. The study descriptions, demographic details, methodology, and outcomes were assessed. Results A total of six studies were included. In vitro studies and animal trials demonstrated the efficacy of PRP in achieving watertight dural closure and prevention of CSF leaks when standard suturing techniques failed. PRP application in rat models have been shown to cause increased dura mater thickness and enhanced vascularity. Clinical cases revealed mixed outcomes, with some patients experiencing symptom relief and improved radiological findings after PRP interventions, while a minority faced recurrent symptoms. Conclusion PRP is a promising tool to achieve water-tight dural closure. Although the clinical evidence is limited at this juncture, its feasibility, cost-effectiveness, and safety profile make it suitable for initiating clinical trials to assess its optimal clinical application.

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Section: Preparation Of Prpmentioning

confidence: 99%

Section: Preparation Of Prpmentioning

confidence: 99%

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Platelet-Rich Plasma-A Safe and Cost-effective Dural Sealant in Spinal Surgeries-A Systematic Review

Aziz,

Yaqoob,

Tariq

et al. 2024

Preprint

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“…15 In recent years, PRP has garnered considerable interest and shown promising results in a variety of medical disciplines, including orthopaedics, dermatology, obstetrics, dentistry and otolaryngology. [16][17][18][19][20][21] In sinus surgery, the prospective benefits of PRP are compelling.…”

Section: Introductionmentioning

confidence: 99%

Platelet‐rich plasma following endoscopic sinus surgery in patients with chronic sinusitis: A systematic review and meta‐analysis of randomised controlled trials

Albazee,

Alsubaie,

Alkanderi

et al. 2024

Clinical Otolaryngology

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IntroductionTo comprehensively evaluate the reported clinical effectiveness of platelet‐rich plasma (PRP) in patients with chronic sinusitis undergoing endoscopic sinus surgery (ESS).MethodsWe performed a systematic review and meta‐analysis of randomised controlled trials (RCTs). Five digital online databases (PubMed, Scopus, Web of Science, Google Scholar and Cochrane CENTRAL) were searched from inception up to 1st May 2023. Our specific outcomes involved postoperative nasal endoscopy scores measured via Lund‐Kennedy score or Meltzer score, olfactory sensation scores and pre‐operative anosmia duration. All data were pooled as standardised mean difference (SMD) with a 95% confidence interval (CI), using the RevMan software.ResultsSix RCTs were included in this systematic review and meta‐analysis, with a total of 169 patients. The risk of bias in the included RCTs was low in three RCTs, some concerns in one RCT and high risk in two RCTs. The overall analysis of the postoperative nasal endoscopy scores showed that the PRP group had lower scores compared to the control group (n = 3 RCTs, SMD = −1.19; 95% CI [−1.94, −0.44], p = .002). There was no significant difference between the PRP and control groups regarding anosmia duration (n = 2 RCTs, SMD = 0.21; 95% CI [−0.17, 0.59], p = 0.28) or olfactory sensation scores, despite the PRP group having higher scores (n = 2 RCTs, SMD = 0.53; 95% CI [−0.32, 1.39], p = 0.22).ConclusionThis study highlights the potential advantages of using PRP as an additional treatment for individuals with chronic sinusitis undergoing ESS. The improvements associated with PRP include facilitating wound healing, reducing inflammation and enhancing surgical outcomes. To optimise the use of PRP in clinical settings, future research should focus on conducting larger trials with standardised protocols.

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Strategies to use fibrinogen as bioink for 3D bioprinting fibrin-based soft and hard tissues

et al. 2020

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Use of intraarticular injections of platelet-rich plasma in the treatment of knee osteoarthritis: A review article

Cited by 6 publications

References 54 publications

Platelet-Rich Plasma-A Safe and Cost-effective Dural Sealant in Spinal Surgeries-A Systematic Review

Platelet-Rich Plasma-A Safe and Cost-effective Dural Sealant in Spinal Surgeries-A Systematic Review

Platelet‐rich plasma following endoscopic sinus surgery in patients with chronic sinusitis: A systematic review and meta‐analysis of randomised controlled trials

Strategies to use fibrinogen as bioink for 3D bioprinting fibrin-based soft and hard tissues

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