Use of Intravenous Immunoglobulin to Prevent or Treat Infections in Persons With Immune Deficiency

Ml, Lee; Rp, Gale; Pl, Yap

doi:10.1146/annurev.med.48.1.93

Cited by 41 publications

(1 citation statement)

References 79 publications

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“…Patients with multiple myeloma and chronic lymphoid leukemia, when they concomitantly have a low level of immunoglobulins and recurrent bacterial infections, are also candidates for Ig therapy. (5,6) …”

Section: Approved Indications For Immunoglobulinmentioning

confidence: 99%

Clinical applications of immunoglobulin

Novaretti

Dinardo

2011

Rev. Bras. Hematol. Hemoter.

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Human immunoglobulin is the most used blood product in the clinical practice. Immunoglobulin applications have increased quickly since the elucidation of its immunomodulatory and antiinflammatory properties which turned this blood product into a precious tool in the treatment of numerous diseases that present with humoral immune deficiency or that cause immune system dysfunction. Currently, the approved indications for Ig are: primary immunodeficiencies, secondary immunodeficiencies (multiple myeloma or chronic lymphoid leukemia), Kawasaki syndrome, immune thrombocytopenic purpura, Guillain Barré syndrome, graft-versus-host disease following bone marrow transplantation and repeat infections in HIV children. On the other hand, there are numerous "off-label" indications of immunoglobulin, which represent 20-60% of all clinical applications of this drug. It is important to study all these indications and, above all, the scientific evidence for its use, in order to provide patients with a new therapeutic option without burdening the health system. This review results from a wide selection of papers identified in the Pubmed and Lilacs scientific electronic databases. A group of descriptors were used from human immunoglobulin to the names of each disease that immunoglobulin is clinically applied. Our main objective is to list the numerous indications of immunoglobulin, both authorized and "off-label" and to analyze these indications in the light of the most recent scientific evidence.

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Section: Approved Indications For Immunoglobulinmentioning

confidence: 99%