Use of Intravenous Iodinated Contrast Media in Patients With Kidney Disease

Abstract

Intravenous iodinated contrast media are commonly used with CT to evaluate disease and to determine treatment response. The risk of acute kidney injury (AKI) developing in patients with reduced kidney function following exposure to intravenous iodinated contrast media has been overstated. This is due primarily to historic lack of control groups sufficient to separate contrast-induced AKI (CI-AKI; ie, AKI caused by contrast media administration) from contrast-associated AKI (CA-AKI; ie, AKI coincident to contrast media administration). Although the true risk of CI-AKI remains uncertain for patients with severe kidney disease, prophylaxis with intravenous normal saline is indicated for patients who have AKI or an estimated glomerular filtration rate less than 30 mL/min/1.73 m 2 who are not undergoing maintenance dialysis. In individual high-risk circumstances, prophylaxis may be considered in patients with an estimated glomerular filtration rate of 30–44 mL/min/1.73 m 2 at the discretion of the ordering clinician.

Morphological and radiological study of lymph nodes in dromedaries in Algeria

“…The preparation of the lymph nodes with a contrast agent showed us a thick layer like an envelope penetrating the organ and forming internal lobular cavities, the medullary zones are very clear by the trajectories of the trabecular spans corresponding to the opening of the channels of the hilum, the same results were found in the lymph nodes of cattle by researchers (Gadre et al, 2018). This exploration technique is still being improved to highlight the various anomalies of the lymphatic circulation using non-harmful contrast agents (Davenport et al, 2020). The three-dimensional architecture of the lymph nodes highlighted by computer tomography reveals the presence of segments of the parenchyma formed of a distinct structural unit, surrounded by a layer of connective tissue of variable shape; these results have been cited by the authors (Sun et al, 2019).…”

Association between urine pH and risk of contrast-associated acute kidney injury among patients after emergency percutaneous coronary intervention: a V-shape relationship?

“…The primary endpoint was CA-AKI, defined as an absolute increase ≥ 0.3 mg/dL or a relative increase ≥ 50% from baseline serum creatinine within 48 h of contrast medium exposure [ 11 , 12 ]. Additional end points were long-term mortality.…”

Use of Intravenous Gadolinium-Based Contrast Media in Patients With Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation

“…Recommended definitions pertaining to intravenous contrast media administration for acute kidney injury (AKI), chronic kidney disease (CKD), contrast-induced acute kidney injury, and contrast-associated acute kidney injury are provided in a previously published ACR-NKF consensus document on intravenous iodinated contrast media. 4 …”

“…Details of kidney function screening including methods and risk factors are provided in a previously published ACR-NKF consensus document on intravenous iodinated contrast media. 4 …”