Use of iPSC-derived brain organoids to study human brain evolution

Reiner, Orly; Sapir, Tamar; Parichha, Arpan

doi:10.1016/b978-0-12-822231-7.00012-6

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Bottom-up Reconstruction Of Neurogenetic Evolution1

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2023

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“…Linking these technologies enables workflows for a large-scale identification and mechanistic dissection of human evolution from molecular to cellular levels that can be probed in genetically engineered rodent and primate models ( Pollen et al. 2023 ; Reiner et al. 2021 ).…”

Section: Bottom-up Reconstruction Of Neurogenetic Evolutionmentioning

confidence: 99%

Towards correlative archaeology of the human mind

Piszczek,

Kaczanowska,

Haubensak

2023

Biological Chemistry

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Retracing human cognitive origins started out at the systems level with the top-down interpretation of archaeological records spanning from man-made artifacts to endocasts of ancient skulls. With emerging evolutionary genetics and organoid technologies, it is now possible to deconstruct evolutionary processes on a molecular/cellular level from the bottom-up by functionally testing archaic alleles in experimental models. The current challenge is to complement these approaches with novel strategies that allow a holistic reconstruction of evolutionary patterns across human cognitive domains. We argue that computational neuroarcheology can provide such a critical mesoscale framework at the brain network-level, linking molecular/cellular (bottom-up) to systems (top-down) level data for the correlative archeology of the human mind.

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Section: Bottom-up Reconstruction Of Neurogenetic Evolutionmentioning

confidence: 99%