Use of Isolated Pectin from a Cissampelos pareira-Based Polymer Blend Matrix for the Transdermal Delivery of Nicotine

Suksaeree, Jirapornchai; Karnsopa, Phatipan; Wannaphruek, Nannapat; Prasomkij, Jessada; Panrat, Kamon; Monton, Chaowalit; Pichayakorn, Wiwat

doi:10.1007/s10924-018-1233-4

Cited by 14 publications

(6 citation statements)

References 36 publications

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“…Pectin is a hydrophilic polysaccharide that occurs naturally and is increasingly used in the pharmaceutical and biotechnology industries [27,28]. It is inexpensive, biodegradable, biocompatible, and renewable, thus encouraging researchers to investigate its possible use in industrial applications [29][30][31]. However, the low chemical resistance and microbial attack limit industrial applications of pectin.…”

Section: Introductionmentioning

confidence: 99%

Gamma irradiation synthesis of pectin- based biohydrogels for removal of lead cations from simulated solutions

et al. 2022

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Bio-based hydrogels (denoted as PC-PAAc/GA) comprised of Pectin (PC) and polyacrylic acid (PAAc) reinforced with different ratios of gallic acid (GA) were prepared by gamma radiation at irradiation dose 20 kGy. The prepared hydrogels were investigated by different analytical tools. The swelling performance was studied versus time, pH of the medium and gallic acid content. The experimental data depicted that the swelling increases with pH of medium until the equilibrium of swelling after 350 min. The maximum swelling was attained at pH10 for both PC-PAAc and PC-PAA/GA1.5. Also, the data reveal that the incorporation of GA in the hydrogel matrix enhanced the swelling performance of the hydrogel up to an optimum value of GA, i.e. PC-PAA/GA1.5. Further increase in GA concentration leads to formation of a highly crosslinked structure with reduced swelling. The results demonstrated that the prepared hydrogels displayed excellent antibacterial activity against gram + ve bacteria (E.coli) and gram-ve bacteria (S.aureus). This potent antimicrobial activity is mainly originated from GA which was proved as a strong antibacterial agent. Moreover, the removal performance of the investigated hydrogels was verified towards Pb+2 cation as one of the most poisonous heavy metals. The data revealed that the maximum removal percentage of Pb (II) was attained by PC-PAAc/GA1.5 hydrogel (90 mg g−1). The correlation coefficients of the Langmuir model are too higher than that of the Freundlich model that assumed the adsorption of lead cations is mainly a chemical process.

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Section: Introductionmentioning

confidence: 99%

Gamma irradiation synthesis of pectin- based biohydrogels for removal of lead cations from simulated solutions

et al. 2022

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“…Some of the pharmaceutical applications of pectin are to diminish lipid digestion [ 12 ]⁠, to improve lipid hepatic accumulation [ 13 ]⁠, glucose tolerance for antidiabetic effects [ 14 ]⁠, and its anti-inflammatory activity in high methoxyl pectins [ 15 ]⁠. Recently, the low hydrophilic of pectin has taken advantage to improve carrier properties and diffusion control of nicotine in transdermal patches [ 16 , 17 ]⁠ and drug delivery such as theophylline tablets [ 18 ]⁠ and lidocaine and aspirin in ionic liquid [ 19 ]⁠.…”

Section: Introductionmentioning

confidence: 99%

Optimization and Preliminary Physicochemical Characterization of Pectin Extraction from Watermelon Rind (Citrullus lanatus) with Citric Acid

Pérez

Gómez

Vega

2022

International Journal of Food Science

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Watermelon rind was used for the pectin extraction with citric acid as the extractant solvent. The effects of pH (2.0-3.0), extraction time (45-75 min), and liquid-solid ratio (10 : 1 to 40 : 1 mL/g) on the pectin yield, degree of esterification, methoxyl content, and anhydrouronic acid content were investigated using Box-Behnken surface response experimental design. The pH was the most significant variable for the pectin yield and properties. The responses optimized separately showed different optimal conditions for each one of the variables studied in this work. Therefore, the desirability function was used to determine the sole theoretical optimum for the highest pectin yield and highest anhydrouronic acid content, which was found to be pH of 2.0, extraction time of 62.31 min, and liquid-solid ratio of 35.07 mL/g. Under this optimal condition, the pectin yield, degree of esterification, methoxyl content, and anhydrouronic acid content were 24.30%, 73.30%, 10.45%, and 81.33%, respectively. At optimal conditions, watermelon rind pectin can be classified as high methoxyl and rapid-set pectin with high quality and high purity. Practical Applications. This study evaluated the pectin extraction from watermelon rind and carried out an optimization of multiple responses as a function of pH, time, and liquid-solid ratio to obtain the best preliminary quality parameters (pectin yield and anhydrouronic acid content). The results revealed that watermelon rind waste can be an inexpensive source to obtain good pectin quality and high purity. According to the chemical characterization and physicochemical properties studied, the extracted pectin from watermelon rind would have a high potential to be used in food industry.

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“…10 Some researchers were attributed to the application of DPNR in transdermal patches. [11][12][13][14][15][16] However, the removal of proteins will lead to a decrease on the tensile strength of NR, which makes the fabrication of high-performance DPNR even more challenging. 17,18 Introducing rigid nano-fillers is an effective way to reinforce and functionalize the rubber materials.…”

Section: Introductionmentioning

confidence: 99%

Preparation of high‐performance deproteinized natural rubber/chitosan composite films via a green and sulfur‐free method

Yuan

Sun

Tian

et al. 2022

J of Applied Polymer Sci

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To solve the environment and health issues arose from the sulfur vulcanization, a facile and completely eco-friendly method of latex-assembly and in situ cross-linking is developed to prepare fully bio-based and high-performance rubber films. The films are featured by a "reinforced concrete" structure composed of dynamically cross-linked chitosan framework and unvulcanized deproteinized natural rubber (DPNR) matrix. The self-assembly of DPNR latex particles and chitosan, as well as the in situ cross-linking of chitosan in the film forming process are confirmed by transmission electron microscope and dynamic light scattering. As green rubbers without vulcanization, the asdesigned composite films possess excellent mechanic properties comparable to those of the sulfur vulcanized DPNR film, whose tensile strength and toughness reach 15.2 MPa and 77.6 MJ m À3 respectively. Moreover, the films exhibited appropriate permeability to moisture and achievable reprocessing, which have potential applications in wearable devices.

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Use of Isolated Pectin from a Cissampelos pareira-Based Polymer Blend Matrix for the Transdermal Delivery of Nicotine

Cited by 14 publications

References 36 publications

Gamma irradiation synthesis of pectin- based biohydrogels for removal of lead cations from simulated solutions

Gamma irradiation synthesis of pectin- based biohydrogels for removal of lead cations from simulated solutions

Optimization and Preliminary Physicochemical Characterization of Pectin Extraction from Watermelon Rind (Citrullus lanatus) with Citric Acid

Preparation of high‐performance deproteinized natural rubber/chitosan composite films via a green and sulfur‐free method

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