Use of Kidneys From Trypanosoma Cruzi–Infected Donors in Naive Transplant Recipients Without Prophylactic Therapy

Cicora, Federico; Escurra, Verónica; Silguero, Sergio; González, Irati Tapia; Roberti, Javier

doi:10.1097/01.tp.0000437673.86339.82

Cited by 19 publications

(11 citation statements)

References 10 publications

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“…The use of grafts from infected donors is acceptable when patients are monitored closely and treated promptly . However, we and others frequently perform and have reported kidney transplants of infected organs with good results, even when recipients are not administered prophylactic therapies . The tumor‐like form can occur years after infection and has been described in patients with acquired immunodeficiency syndrome (AIDS), and in a very few cases in transplant recipients .…”

mentioning

confidence: 99%

Cerebral trypanosomiasis in a renal transplant recipient

Cicora¹,

Escurra²,

Bibolini³

et al. 2014

Transplant Infectious Dis

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Chagas disease is a lifelong, systemic, parasitic infection caused by the protozoan Trypanosoma cruzi. The main form of disease transmission is vector borne, but vertical transmission, such as by organ transplantation from a chronically infected donor, is also possible. The brain tumor-like form can occur years after infection and has been described in patients with acquired immunodeficiency syndrome, and in a very few cases in transplant recipients. We describe the case of a kidney transplant patient who was human immunodeficiency virus negative and infected with T. cruzi, and developed cerebral trypanosomiasis that was successfully treated with benznidazole at 7 mg/kg/day for 60 days. The risk of Chagas disease transmission should not be underestimated in renal transplant patients, even in non-endemic areas. Chagas disease can present as a tumor-like brain lesion, very difficult to differentiate from other opportunistic infectious or neoplastic processes. Frequent monitoring for T. cruzi infection is essential to promptly implement treatment, which, in our patient, proved to be effective and safe.

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mentioning

confidence: 99%

Cerebral trypanosomiasis in a renal transplant recipient

Cicora¹,

Escurra²,

Bibolini³

et al. 2014

Transplant Infectious Dis

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“…Strongyloides has come from donors typically from the Caribbean, amoebae from warm, fresh water sources, Chagas' disease from individuals spending substantial time in Central America, and toxoplasmosis from just about anyone exposed to infected cats [21][22][23][24]. Certainly, not every donor from a specific geographic area will transmit an infection to an organ recipient, but when there is a substantial risk, caution must be exercised.…”

Section: Parasitesmentioning

confidence: 97%

Receiving the Unwanted Gift: Infection Transmission through Organ Transplantation

Kirchner

Pruett

2016

Surgical Infections

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“…The assessment of the risk of transmission of CD by organ transplantation from seropositive donor (D+) to seronegative recipient (R-) is based on a limited number of studies, which are generally retrospective and with short follow-up, as seen in Table 1 [21][22][23][24][25][26][27][28][29][30]. The average prevalence was 19.3%, ranging from 9.6% for kidney transplant, 17.1% for liver transplant, to 75% for heart transplant [24,[27][28][29][30].…”

Section: Risk Of Transmission By Infected Donormentioning

confidence: 99%

Chagas Disease, Leishmaniasis, and Malaria in Solid Organ Transplant Recipients

Antinori¹,

Milazzo²

2018

obm transplant

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Solid organ transplantation (SOT) is increasingly employed worldwide to treat several diseases causing both acute and chronic organ failure. Recipients of SOT are at an increased risk to develop infections as a consequence of immunosuppressive therapy. Sometimes such infections may be acquired by the transplanted organ or by reactivation of a previously acquired latent infection. The globalization and the increase of international travel poses a risk for exposure to infections such as Chagas disease (CD), leishmaniasis, and malaria endemic in tropical and subtropical areas of the world. We have reviewed the literature regarding risk factors, clinical presentation, diagnosis, and treatment of CD, leishmaniasis, and malaria in the setting of SOT.

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Use of Kidneys From Trypanosoma Cruzi–Infected Donors in Naive Transplant Recipients Without Prophylactic Therapy

Cited by 19 publications

References 10 publications

Cerebral trypanosomiasis in a renal transplant recipient

Cerebral trypanosomiasis in a renal transplant recipient

Receiving the Unwanted Gift: Infection Transmission through Organ Transplantation

Chagas Disease, Leishmaniasis, and Malaria in Solid Organ Transplant Recipients

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